Antiobesity and hypolipidemic effects of polyphenol-rich longan (dimocarpus longans lour.) flower water extract in hypercaloric-dietary rats

Deng Jye Yang, Yuan Yen Chang, Chin Lin Hsu, Cheng Wei Liu, Y. I.Ling Lin, Y. U.Huei Lin, Kai Cheng Liu, Y. I.Chen Chen

研究成果: Article同行評審

70 引文 斯高帕斯(Scopus)

摘要

Plenty of polyphenols, i.e. phenolic acids and flavonoids, were found in longan flower water extract (LFWE) through spectrophotometric and HPLC analyses. Antiobesity and hypolipidemic effects of polyphenol-rich longan flower water extract (LFWE) were investigated in this study. Eight male rats per group were assigned randomly to one of the following dietary groups: (1) normal-caloric diet and pure water (NCD + NDW); (2) hypercaloric diet and pure water (HCD+ NDW); (3) HCD and 1.25% (w/v) LFWE (HCD + 1.25% LFWE); (4) HCD and 2.5% (w/v) LFWE (HCD + 2.5% LFWE) for 9 weeks. Body weight, size of epididymal fat, serum triglyceride level and atherogenic index, and hepatic lipids were decreased (p < 0.05) in HCD rats by drinking 2.5% LFWE which may result from downregulated (p<0.05) pancreatic lipase activity, and sterol regulatory element binding protein-1c (SREBP-1c) and fatty acid synthase (FAS) gene expressions, as well as upregulated (p < 0.05) LDL receptor (LDLR) and peroxisome proliferator-activated-receptor-alpha (PPAR-α) gene expressions, and also increased (p <0.05) fecal triglyceride excretions. Therefore, polyphenol-rich LFWE indeed characterizes antiobesity and hypolipidemic effects in vivo.

原文English
頁(從 - 到)2020-2027
頁數8
期刊Journal of Agricultural and Food Chemistry
58
發行號3
DOIs
出版狀態Published - 10 2月 2010

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