Antifouling strategies in advanced electrochemical sensors and biosensors

Pei Heng Lin, Bor-Ran Li*

*此作品的通信作者

研究成果: Review article同行評審

151 引文 斯高帕斯(Scopus)

摘要

Electrochemical biosensors have been applied in a broad range of clinical applications for pathogen biomarker detection and medical applications and diagnosis due to the sensitivity of electrochemical methods and the bioselectivity of the components. The complexity of clinical conditions with various biofoulants (proteins, cells, polysaccharides and lipids) severely influences the reliability and stability of sensors for direct detection or immersion under changing conditions. Therefore, designing an antifouling sensing platform that can effectively reduce undesired binding to maintain biosensor performance in optimized analysis is necessary. For this purpose, the fundamental mechanisms of fouling materials and commonly used biocompatible antifouling components have been discussed, and the relevant effective modification strategies are introduced in this review. Recent advances in these strategies are demonstrated in examples with analysis of essential modification methods for reliable sensing in non-specific binding solutions or complex biofluids. The challenges and future perspectives of modification strategies for current clinical application are also discussed in this review.

原文English
頁(從 - 到)1110-1120
頁數11
期刊Analyst
145
發行號4
DOIs
出版狀態Published - 21 2月 2020

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