Antiallergic asthma properties of Brazilin through inhibition of T H2 responses in T cells and in a murine model of asthma

Chen Chen Lee*, Chien Neng Wang, Jaw Jou Kang, Jiunn Wang Liao, Bor Luen Chiang, Hui Chen Chen, Chien Ming Hu, Chia Der Lin, Shih Hsuan Huang, Yu Ting Lai

*此作品的通信作者

研究成果: Review article同行評審

25 引文 斯高帕斯(Scopus)

摘要

This study aimed to determine whether brazilin exhibits anti-inflammatory effects that inhibit T helper cell type II (TH2) responses and whether it suppresses allergic inflammation reactions in a murine model of asthma. We found that brazilin inhibited the mRNA and protein expression of interleukin (IL)-4 and IL-5 induced by phorbol myristate acetate (PMA) and cAMP in EL-4 T cells in a dose-dependent manner. Following the intratracheal instillation of brazilin in ovalbumin (OVA)-immunized mice, we found that brazilin-treated mice exhibited decreases in the release of IL-4, IL-5, IL-13, eotaxin-1, and tumor necrosis factor-α in bronchoalveolar lavage fluid (BALF); inhibited TH2 functioning via a decrease in IL-4 production; and exhibited attenuation of OVA-induced lung eosinophilia, airway hyperresponsiveness, and airway remodeling. These results suggest that brazilin exhibits anti-TH2 effects both in vitro and in vivo and may possess therapeutic potential for allergic diseases.

原文English
頁(從 - 到)9405-9414
頁數10
期刊Journal of Agricultural and Food Chemistry
60
發行號37
DOIs
出版狀態Published - 19 9月 2012

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