Analysis of genetic aberrations in uterine adenomyosis using comparative genomic hybridization

Peng Hui Wang; Wen Yuann Shyong; Chi Hung Lin; Yann Jang Chen; Feng Li Ywan; Hsiang Tai Chao; Chiou Chung Yuan

Analysis of genetic aberrations in uterine adenomyosis using comparative genomic hybridization

Peng Hui Wang^*, Wen Yuann Shyong, Chi Hung Lin, Yann Jang Chen, Feng Li Ywan, Hsiang Tai Chao, Chiou Chung Yuan

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11 引文斯高帕斯（Scopus）

摘要

OBJECTIVE: To use comparative genomic hybridization (CGH) to analyze frozen tissues from adenomyosis cases to discover and map genomic regions for chromosomal gains and losses. STUDY DESIGN: In a retrospective study, upper and lower threshold values of 1.20 and 0.80, respectively, were used to define positive findings. RESULTS: No positive recurrent gene copy number alterations were detected in the 25 cases of pathologically proven adenomyosis. CONCLUSION: Although CGH is extremely useful in investigating candidate genes in the development of adenomyosis, CGH was not useful in this study. Genetic changes might be indeed extremely rare in adenomyosis, or CGH was not sensitive enough to detect candidate genes.

原文	English
頁（從 - 到）	1-6
頁數	6
期刊	Analytical and Quantitative Cytology and Histology
卷	24
發行號	1
出版狀態	Published - 2002

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title = "Analysis of genetic aberrations in uterine adenomyosis using comparative genomic hybridization",

abstract = "OBJECTIVE: To use comparative genomic hybridization (CGH) to analyze frozen tissues from adenomyosis cases to discover and map genomic regions for chromosomal gains and losses. STUDY DESIGN: In a retrospective study, upper and lower threshold values of 1.20 and 0.80, respectively, were used to define positive findings. RESULTS: No positive recurrent gene copy number alterations were detected in the 25 cases of pathologically proven adenomyosis. CONCLUSION: Although CGH is extremely useful in investigating candidate genes in the development of adenomyosis, CGH was not useful in this study. Genetic changes might be indeed extremely rare in adenomyosis, or CGH was not sensitive enough to detect candidate genes.",

keywords = "Adenomyosis, Genes, Genetic aberrations, Genomic hybridization, Uterine diseases",

author = "Wang, {Peng Hui} and Shyong, {Wen Yuann} and Lin, {Chi Hung} and Chen, {Yann Jang} and Ywan, {Feng Li} and Chao, {Hsiang Tai} and Yuan, {Chiou Chung}",

year = "2002",

language = "English",

volume = "24",

pages = "1--6",

journal = "Analytical and Quantitative Cytopathology and Histopathology",

issn = "0884-6812",

publisher = "Science Printers and Publishers Inc.",

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TY - JOUR

T1 - Analysis of genetic aberrations in uterine adenomyosis using comparative genomic hybridization

AU - Wang, Peng Hui

AU - Shyong, Wen Yuann

AU - Lin, Chi Hung

AU - Chen, Yann Jang

AU - Ywan, Feng Li

AU - Chao, Hsiang Tai

AU - Yuan, Chiou Chung

PY - 2002

Y1 - 2002

N2 - OBJECTIVE: To use comparative genomic hybridization (CGH) to analyze frozen tissues from adenomyosis cases to discover and map genomic regions for chromosomal gains and losses. STUDY DESIGN: In a retrospective study, upper and lower threshold values of 1.20 and 0.80, respectively, were used to define positive findings. RESULTS: No positive recurrent gene copy number alterations were detected in the 25 cases of pathologically proven adenomyosis. CONCLUSION: Although CGH is extremely useful in investigating candidate genes in the development of adenomyosis, CGH was not useful in this study. Genetic changes might be indeed extremely rare in adenomyosis, or CGH was not sensitive enough to detect candidate genes.

AB - OBJECTIVE: To use comparative genomic hybridization (CGH) to analyze frozen tissues from adenomyosis cases to discover and map genomic regions for chromosomal gains and losses. STUDY DESIGN: In a retrospective study, upper and lower threshold values of 1.20 and 0.80, respectively, were used to define positive findings. RESULTS: No positive recurrent gene copy number alterations were detected in the 25 cases of pathologically proven adenomyosis. CONCLUSION: Although CGH is extremely useful in investigating candidate genes in the development of adenomyosis, CGH was not useful in this study. Genetic changes might be indeed extremely rare in adenomyosis, or CGH was not sensitive enough to detect candidate genes.

KW - Adenomyosis

KW - Genes

KW - Genetic aberrations

KW - Genomic hybridization

KW - Uterine diseases

UR - http://www.scopus.com/inward/record.url?scp=0036181564&partnerID=8YFLogxK

M3 - Article

C2 - 11865944

AN - SCOPUS:0036181564

SN - 0884-6812

VL - 24

SP - 1

EP - 6

JO - Analytical and Quantitative Cytopathology and Histopathology

JF - Analytical and Quantitative Cytopathology and Histopathology

IS - 1

ER -

Analysis of genetic aberrations in uterine adenomyosis using comparative genomic hybridization

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