TY - CHAP
T1 - Analysis of Circulating Tumor DNA in Patients with Cancer
T2 - A Clinical Perspective
AU - Yeh, Chi Chun
AU - Chang, Peter Mu Hsin
N1 - Publisher Copyright:
© 2020 by World Scientific Publishing Co. Pte. Ltd.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Somatic genomic alterations are drivers of initiation, progression, and development of resistance to treatment of cancer. Analysis of circulating tumor DNA (ctDNA) enables detection of somatic genomic alteration non-invasively with a simple blood draw. ctDNA analysis may overcome the obstacles of spatial and temporal genomic heterogeneity of cancer and may provide essential information to facilitate an informed clinical decision-making. Emerging evidence has demonstrated clinical utility of ctDNA in directing treatment option, determining prognosis of patients, detecting recurrence of cancer, and detecting early primary cancer. Methods are developed to achieve detection of genomic alterations with high sensitivity and specificity. A brief review of clinical applications of ctDNA analysis is provided.
AB - Somatic genomic alterations are drivers of initiation, progression, and development of resistance to treatment of cancer. Analysis of circulating tumor DNA (ctDNA) enables detection of somatic genomic alteration non-invasively with a simple blood draw. ctDNA analysis may overcome the obstacles of spatial and temporal genomic heterogeneity of cancer and may provide essential information to facilitate an informed clinical decision-making. Emerging evidence has demonstrated clinical utility of ctDNA in directing treatment option, determining prognosis of patients, detecting recurrence of cancer, and detecting early primary cancer. Methods are developed to achieve detection of genomic alterations with high sensitivity and specificity. A brief review of clinical applications of ctDNA analysis is provided.
KW - cancer
KW - cell-free DNA (cfDNA)
KW - circulating tumor DNA (ctDNA)
KW - next-generation sequencing (NGS)
UR - http://www.scopus.com/inward/record.url?scp=85135970344&partnerID=8YFLogxK
U2 - 10.1142/9789811203589_0004
DO - 10.1142/9789811203589_0004
M3 - Chapter
AN - SCOPUS:85135970344
SN - 9789811203572
SP - 47
EP - 58
BT - Application of Omics, Ai and Blockchain in Bioinformatics Research
PB - World Scientific Publishing Co.
ER -
