Analysis of Circulating Tumor DNA in Patients with Cancer: A Clinical Perspective

Chi Chun Yeh, Peter Mu Hsin Chang

研究成果: Chapter同行評審

摘要

Somatic genomic alterations are drivers of initiation, progression, and development of resistance to treatment of cancer. Analysis of circulating tumor DNA (ctDNA) enables detection of somatic genomic alteration non-invasively with a simple blood draw. ctDNA analysis may overcome the obstacles of spatial and temporal genomic heterogeneity of cancer and may provide essential information to facilitate an informed clinical decision-making. Emerging evidence has demonstrated clinical utility of ctDNA in directing treatment option, determining prognosis of patients, detecting recurrence of cancer, and detecting early primary cancer. Methods are developed to achieve detection of genomic alterations with high sensitivity and specificity. A brief review of clinical applications of ctDNA analysis is provided.

原文English
主出版物標題Application of Omics, Ai and Blockchain in Bioinformatics Research
發行者World Scientific Publishing Co.
頁面47-58
頁數12
ISBN(電子)9789811203589
ISBN(列印)9789811203572
DOIs
出版狀態Published - 1 1月 2019

指紋

深入研究「Analysis of Circulating Tumor DNA in Patients with Cancer: A Clinical Perspective」主題。共同形成了獨特的指紋。

引用此