An integrated biodegradable, immunoprotective, dual nanoporous capsule for cell-based therapies

Xulang Zhang*, Hongyan He, Chi Yen, Winston Ho, L. James Lee

*此作品的通信作者

研究成果: Conference contribution同行評審

摘要

In summary, a new biodegradable cell-based device has been developed based on the integration of two techniques: microcapsules and surface coated PCL capsule. Microcapsules provide a 3-D microenvironment for spatial cell growth with good viability and proliferation. Coating biocompatible and hydrophilic PEG gelatin on the PCL surface could mediate the inflammatory response, minimize the fibrosis formation, and maintain the release performance. Our ongoing work is to test AP and PCL nanoporous membrane immunoprotection and controlled release functions for therapeutic cell secreting products. Hopefully, the dual nanoporous construct provides a unique way to allow superior cell growth, immuoprotection, fibrosis prevention and controllable release of secreted product in a biodegradable device.

原文English
主出版物標題AIChE100 - 2008 AIChE Annual Meeting, Conference Proceedings
頁數11
出版狀態Published - 11月 2008
事件2008 AIChE Annual Meeting, AIChE 100 - Philadelphia, PA, United States
持續時間: 16 11月 200821 11月 2008

出版系列

名字AIChE Annual Meeting, Conference Proceedings

Conference

Conference2008 AIChE Annual Meeting, AIChE 100
國家/地區United States
城市Philadelphia, PA
期間16/11/0821/11/08

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