An Inkjet-Printed Flexible Non-Enzymatic Lactate Sensor for Clinical Blood Plasma Test

Yi Syuan Huang, Kuan Yu Chen, Yu Ting Cheng*, Chih Kuo Lee, Hsiao En Tsai

*此作品的通信作者

    研究成果: Article同行評審

    5 引文 斯高帕斯(Scopus)

    摘要

    In this letter, we demonstrate a fully inkjet-printed electrochemical lactate sensor. The sensor is inkjet-printed on a flexible substrate, Kapton film, where silver nanoparticles (Ag NPs) are printed as conductive electrodes. The working and reference electrodes of the sensor are Ag NPs/NiO NPs/Polyurethane (PU) and Ag/AgCl(s)/PU layers respectively. The inkjet-printed PU film can not only prevent the annihilation of the Ag NPs resulting from the dissolution of Ag and the formation of AgCl in the phosphate-buffered saline (PBS) but also stabilize the lactic acid measurements by maintaining a potential variant within 2% at different lactate concentrations. The as-printed sensor exhibits a linear sensitivity of 8.86nA/mM/mm2 (R=99.6%) in the range from 0.6 to 2.2 mM. Clinical blood plasma testing results show that the trends of lactic acid change in patients measured by the sensor are the same as the ones measured using the existing detection method, colorimetric assays, in a tertiary university-affiliated hospital.

    原文English
    文章編號8995650
    頁(從 - 到)597-600
    頁數4
    期刊IEEE Electron Device Letters
    41
    發行號4
    DOIs
    出版狀態Published - 12 二月 2020

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