An extended family of Fc receptor relatives

Randall S. Davis, Goetz R.A. Ehrhardt, Chuen Miin Leu, Masayuki Hirano, Max D. Cooper*

*此作品的通信作者

研究成果: Short survey同行評審

59 引文 斯高帕斯(Scopus)

摘要

A surprising number of Fc receptor (FcR) relatives have been recognized recently with the potential capacity to modulate innate and adaptive immune responses. The six human FcR homologs (FcRH1-6), which belong to a phylogenetically conserved gene family, have variable numbers of extracellular immunoglobulin domains of five different subtypes. FcRH immunoregulatory potential is implicated by the presence of consensus tyrosine-based activation or inhibition motifs in their cytoplasmic tails. All but one of these new receptors, FcRH6, are expressed on B cells at different stages in differentiation. Their ligands, function, and prospective roles as diagnostic B cell markers and therapeutic targets are topics of intense interest.

原文English
頁(從 - 到)674-680
頁數7
期刊European Journal of Immunology
35
發行號3
DOIs
出版狀態Published - 3月 2005

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