An enzymatic approach to configurationally rare trans-androsteronyl-α-glucoside and Its potential anticancer application

Feng Pai Chou, Chia Tse Tsai, Ya Sheng Chiou, Yi Ju Chen, Meng Erh Li, Ting Wei Guo, Jason Wen Jay Lyu, Sheng Hao Chou, Tung-Kung Wu*

*此作品的通信作者

研究成果: Article同行評審

6 引文 斯高帕斯(Scopus)

摘要

Enzymatic glycosylation of sterols/steroids with glycosyltransferase HP0421 shows protein plasticity on generation of configurationally rare steryl-α-glucosides. Investigation of trans-androsteronyl-α-glucoside on tamoxifen-treated MCF-7 breast cancer cells shows dose-dependent depression of cell viability and enhanced drug effectiveness, illustrating a new avenue for the production of novel steryl-α-glucosides with useful biological activities.

原文English
頁(從 - 到)61-66
頁數6
期刊Chemical Biology and Drug Design
89
發行號1
DOIs
出版狀態Published - 1 1月 2017

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