Alterations in the p16INK4a/cyclin D1/RB pathway in gastrointestinal tract endocrine tumors

Anna Fen Yau Li, Alice Chia Heng Li, Shyh How Tsay, Wing Yin Li, Wen Yih Liang, Jeou Yuan Chen

研究成果: Article同行評審

15 引文 斯高帕斯(Scopus)

摘要

A series of 76 cases of gastrointestinal tract endocrine tumors, including 21 poorly differentiated endocrine carcinomas (PDECs, small cell carcinomas) and 55 well-differentiated endocrine neoplasms (WDENs, carcinoids), 18 metastatic and 37 nonmetastatic rectal carcinoids, were examined by immunohistochemical analysis for p16INK4a, cyclin D1, and retinoblastoma protein (pRB) expression. Overexpression of p16INK4a was noted in 16 (76%) of the PDECs and none of the WDENs (P < .0001). Loss of pRB expression was demonstrated in 14 (67%) of the PDECs and 17 (31%) of the WDENs (P = .004). Overexpression of cyclin D1 was noted in 49 (89%) of the WDENs and 3 (14%) of the PDECs (P < .0001). Loss of pRB expression was noted in 11 (61%) of 18 metastatic WDENs and only 6 (16%) of 37 nonmetastatic WDENs (P = .001). The p16INK4a/cyclin D1/pRB pathway was altered in gastrointestinal tract endocrine tumors, and the loss of expression of pRB may be helpful in identifying patients at high risk of metastasis in rectal WDENs.

原文English
頁(從 - 到)535-542
頁數8
期刊American Journal of Clinical Pathology
130
發行號4
DOIs
出版狀態Published - 10月 2008

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