Allergy and risk of childhood acute lymphoblastic leukemia: A population-based and record-based study

Jeffrey S. Chang*, Yi Wen Tsai, Chia Rung Tsai, Joseph L. Wiemels

*此作品的通信作者

研究成果: Article同行評審

25 引文 斯高帕斯(Scopus)

摘要

A deficit of normal immune stimulation in early childhood is a suspected risk factor for both childhood acute lymphoblastic leukemia (ALL) and allergies. The present study utilized a population-based case-control design using medical claims data from the National Health Insurance Research Database of Taiwan to evaluate the association between allergy and childhood leukemia. Eight hundred forty-six childhood ALL patients who were newly diagnosed during 2000 to 2008 and were older than 1 but less than 10 years of age were individually matched with 3,374 controls based on sex, birth date, and time of diagnosis (reference date for the controls). Conditional logistic regression was performed to assess the association between childhood ALL and allergies. An increased risk of ALL was observed with having an allergy less than 1 year before the case's ALL diagnosis (odds ratio (OR) 1.7, 95 confidence interval (CI): 1.5, 2.0), more than 1 year before the case's diagnosis (OR 1.3, 95 CI: 1.1, 1.5), and before the age of 1 year (OR 1.4, 95 CI: 1.1, 1.7). These results suggest that the pathogenesis of childhood ALL and allergy share a common biologic mechanism.

原文English
頁(從 - 到)970-978
頁數9
期刊American Journal of Epidemiology
176
發行號11
DOIs
出版狀態Published - 1 12月 2012

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