All-trans Retinoic Acid Increases Notch1 Transcript Expression in Acute Promyelocytic Leukemia

Jen Tsun Lin*, Ming Shiuan Wu, Wei Shu Wang, Chueh Chuan Yen, Tzeon Jye Chiou, Jin Hwang Liu, Mu Hua Yang, Ta Chon Chao, Shu Chaou Chou, Po Min Chen

*此作品的通信作者

研究成果: Article同行評審

7 引文 斯高帕斯(Scopus)

摘要

The effect of all-trans retinoid acid (ATRA) on the expression of Notch1 gene by real-time reverse transcriptase polymerase chain reaction (RT-PCR) in acute promyelocytic leukemia cells (APL), NB4, and HL-60 lacking t(15;17) was studied. The cells were treated with ATRA 0.5 μM for up to 96 hours. The increased transcript level of Notch1 was in concert with that of CD11b in NB4 cells, but not in HL-60 cells. The expression of Notch1 gene might be specific for APL cells. As Notch1 gene is involved in the differentiation and leukemogenesis in lymphoid neoplasm, observations suggest that Notch1 is involved in ATRA-modulated differentiation process in APL.

原文English
頁(從 - 到)337-343
頁數7
期刊Advances in Therapy
20
發行號6
DOIs
出版狀態Published - 2003

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