@article{d182b5593b1040c99a8aed2accf551bc,
title = "Activity-dependent neuroprotector homeobox protein: A candidate protein identified in serum as diagnostic biomarker for Alzheimer's disease",
abstract = "Alzheimer's disease (AD) is the most common cause of dementia of late life. To enhance our understanding of AD proteome, the serum proteins were analyzed using two-dimensional gel electrophoresis (2DE) combined with nano-high performance liquid chromatography electrospray ionization tandem mass spectrometry (nano-HPLC-ESI-MS/MS) followed by peptide fragmentation patterning. In this study, six protein spots with differential expression were identified. Five up-regulated proteins were identified as actin, apolipoprotein A-IV (Apo A-IV), inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4), alpha-1-antitrypsin (AAT), and antithrombin-III (AT-III); one protein, activity-dependent neuroprotector homeobox protein (ADNP) was down-regulated in AD patients. These proteins with differential expression in the serum may serve as potential indicators of AD. Our results suggested that ADNP may play an important role in slowing the progression of clinical symptoms of AD.",
keywords = "ADNP, Alzheimer's disease, Biomarker, Mass spectrometry, Proteomics",
author = "Yang, \{Ming Hui\} and Yang, \{Yuan Han\} and Lu, \{Chi Yu\} and Jong, \{Shiang Bin\} and Chen, \{Li Jhen\} and Lin, \{Yu Fen\} and Wu, \{Shyh Jong\} and Chu, \{Pei Yu\} and Chung, \{Tze Wen\} and Tyan, \{Yu Chang\}",
note = "Funding Information: We are thankful to S. Sheldon MT (ASCP) of Oklahoma University Medical Center Edmond (USA) for fruitful discussions. The authors thank National Cheng-Kung University Proteomics Research Core Laboratory for the assistance in protein identification. This work was supported by research grants NSC-099-2811-E-22-002 and NSC-100-2320-B-37-007-MY3 from the National Science Council, and NSYSUKMU 101-015 from NSYSU-KMU Joint Research Project, Taiwan, Republic of China. ",
year = "2012",
month = jun,
day = "27",
doi = "10.1016/j.jprot.2012.04.017",
language = "English",
volume = "75",
pages = "3617--3629",
journal = "Journal of Proteomics",
issn = "1874-3919",
publisher = "Elsevier B.V.",
number = "12",
}