Acrolein induces mtDNA damages, mitochondrial fission and mitophagy in human lung cells

Hsiang Tsui Wang*, Jing Heng Lin, Chun Hsiang Yang, Chun Hao Haung, Ching Wen Weng, Anya Maan Yuh Lin, Yu Li Lo, Wei Shen Chen, Moon Shong Tang


研究成果: Article同行評審

21 引文 斯高帕斯(Scopus)


Acrolein (Acr), a highly reactive unsaturated aldehyde, can cause various lung diseases including asthma, chronic obstructive pulmonary disease (COPD), and lung cancer. We have found that Acr can damage not only genomic DNA but also DNA repair proteins causing repair dysfunction and enhancing cells' mutational susceptibility. While these effects may account for Acr lung carcinogenicity, the mechanisms by which Acr induces lung diseases other than cancer are unclear. In this study, we found that Acr induces damages in mitochondrial DNA (mtDNA), inhibits mitochondrial bioenergetics, and alters mtDNA copy number in human lung epithelial cells and fibroblasts. Furthermore, Acr induces mitochondrial fission which is followed by autophagy/ mitophagy and Acr-induced DNA damages can trigger apoptosis. However, the autophagy/ mitophagy process does not change the level of Acr-induced mtDNA damages and apoptosis. We propose that Acr-induced mtDNA damages trigger loss of mtDNA via mitochondrial fission and mitophagy. These processes and mitochondria dysfunction induced by Acr are causes that lead to lung diseases.

頁(從 - 到)70406-70421
出版狀態Published - 2017


深入研究「Acrolein induces mtDNA damages, mitochondrial fission and mitophagy in human lung cells」主題。共同形成了獨特的指紋。