Acetylation of snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages

Dennis Shin Shian Hsu, Hsiao Jung Wang, Shyh Kuan Tai, Chun Hung Chou, Chia Hsin Hsieh, Po Hsien Chiu, Nien Jung Chen, Muh Hwa Yang*

*此作品的通信作者

研究成果: Article同行評審

142 引文 斯高帕斯(Scopus)

摘要

Snail is primarily known as a transcriptional repressor that induces epithelial-mesenchymal transition by suppressing adherent proteins. Emerging evidence suggests that Snail can act as an activator; however, the mechanism and biological significance are unclear. Here, we found that CREB-binding protein (CBP) is the critical factor in Snail-mediated target gene transactivation. CBP interacts with Snail and acetylates Snailat lysine 146 and lysine 187, which prevents the repressor complex formation. We further identified several Snail-activated targets, including TNF-α, which is also the upstream signal for Snail acetylation, and CCL2 and CCL5, which promote the recruitment of tumor-associated macrophages. Here, we present our results on the mechanism by which Snail induces target gene transactivation to remodel the tumor microenvironment.

原文English
頁(從 - 到)534-548
頁數15
期刊Cancer Cell
26
發行號4
DOIs
出版狀態Published - 13 10月 2014

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