ABCA7 gene and the risk of Alzheimer's disease in Han Chinese in Taiwan

Yi Chu Liao, Wei Ju Lee, Jeng Ping Hwang, Yen Feng Wang, Chia Fen Tsai, Pei Ning Wang, Shuu Jiun Wang*, Jong Ling Fuh


研究成果: Article同行評審

33 引文 斯高帕斯(Scopus)


The ATP-binding cassette, subfamily A, member 7 gene (ABCA7) was recently identified as a susceptible gene of Alzheimer's disease (AD) in the Caucasian population and African Americans. To test its genetic effect in the Han-Chinese population, 536 AD cases and 307 cognitive-intact, elder controls were genotyped for ABCA7 rs3764650 and apolipoprotein E (APOE) ε2/ε3/ε4 alleles. Global cognitive performance was assessed by the Mini-Mental State Examination in both AD patients and controls. For AD patients, comprehensive evaluation of each cognitive domain was further conducted as the following: (1) attention (forward and backward digit span); (2) memory (12-item word recall test); (3) executive function (category verbal fluency); (4) processing speed (Trail making test, part A); and (5) naming task (Boston naming test). ABCA7 rs3764650 was significantly associated with AD and the GG genotype carried a reduced risk for AD (odds ratio= 0.52, p= 0.0026). The association was further confirmed in 1802 population-based, healthy controls from Taiwan Biobank as a replicate (odds ratio= 0.70, p= 0.032). After adjustment ofage, sex, and APOE ε4 allele, rs3764650 remained to be an independent predictor of AD (p= 0.001). The influence of ABCA7 was only evident in individuals without APOE ε4 alleles (p= 0.0004) but absent in ε4carriers (p= 0.91). None of the cognitive tests was related to ABCA7 rs3764650 genotypes. The minor allele frequency and effect size of rs3764650 disclosed in the Han-Chinese population differed from those reported in the Caucasians and African Americans. Further studies were warranted to elucidate ABCA7's effect among different ethnic groups.

頁(從 - 到)2423.e7-2423.e13
期刊Neurobiology of Aging
出版狀態Published - 10月 2014


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