TY - JOUR
T1 - A water soluble and fast response fluorescent turn-on copper complex probe for H2S detection in zebra fish
AU - Palanisamy, Sathyadevi
AU - Lee, Lu Ying
AU - Wang, Yu Liang
AU - Chen, Yu Jen
AU - Chen, Chiao Yun
AU - Wang, Yun-Ming
PY - 2016/1/15
Y1 - 2016/1/15
N2 - According to the displacement method, herein we reported a water soluble copper complex [Cu(MaT-cyclen)2] as a fluorescent probe for the detection of H2S. For this, 1-((1-((10-methylanthracen-9-yl)methyl)-1H-1,2,3-triazol-4-yl)methyl)-1,4,7,10-tetraazacyclododecane (MaT-cyclen) was synthesized first. To improve its solubility in aqueous media, sodium acetate group was introduced into 8-hydroxy-2-quinoline successfully. MaT-cyclen was chelated with Cu(II) to form [Cu(MaT-cyclen)2] complex, which displayed high sensitivity and selectivity for H2S over the other possible competitive substances on the basis of forming CuS. Meanwhile, [Cu(MaT-cyclen)2] displayed rapid response (<1 min), well reversibility, lowest detection limit (205 nM), and high sensitivity for recognizing H2S in aqueous solution. Furthermore, its potential utility for biological applications was confirmed by fluorescence imaging of H2S in live cells as well as in zebra fish.
AB - According to the displacement method, herein we reported a water soluble copper complex [Cu(MaT-cyclen)2] as a fluorescent probe for the detection of H2S. For this, 1-((1-((10-methylanthracen-9-yl)methyl)-1H-1,2,3-triazol-4-yl)methyl)-1,4,7,10-tetraazacyclododecane (MaT-cyclen) was synthesized first. To improve its solubility in aqueous media, sodium acetate group was introduced into 8-hydroxy-2-quinoline successfully. MaT-cyclen was chelated with Cu(II) to form [Cu(MaT-cyclen)2] complex, which displayed high sensitivity and selectivity for H2S over the other possible competitive substances on the basis of forming CuS. Meanwhile, [Cu(MaT-cyclen)2] displayed rapid response (<1 min), well reversibility, lowest detection limit (205 nM), and high sensitivity for recognizing H2S in aqueous solution. Furthermore, its potential utility for biological applications was confirmed by fluorescence imaging of H2S in live cells as well as in zebra fish.
KW - Confocal
KW - HS detection
KW - MaT-cyclen
KW - Zebra fish
UR - http://www.scopus.com/inward/record.url?scp=84944390299&partnerID=8YFLogxK
U2 - 10.1016/j.talanta.2015.10.019
DO - 10.1016/j.talanta.2015.10.019
M3 - Article
C2 - 26592631
AN - SCOPUS:84944390299
VL - 147
SP - 445
EP - 452
JO - Talanta
JF - Talanta
SN - 0039-9140
ER -