This brief presents a lab-on-a-chip for cancer cell manipulation and separation. The programmable microelectrode dot array with 115,200 sub-microelectrodes is used to generate traveling wave electric field on the proposed chip. The proposed sub-microelectrode, 5× 5,μ m2 , is useful to improve the traveling field strength under low applied voltage. The proposed chip with area size of 3.2× 2.2 mm2 is implemented in standard 0.18 μ m CMOS process. Experimental results show that MDA-MB-231 cells and HELA cells can be manipulated at the speed of 1.08 μ m /s and 1.5 μ m /s respectively under the supply voltage of 1.8V.
|頁（從 - 到）||1582-1586|
|期刊||IEEE Transactions on Circuits and Systems I: Regular Papers|
|出版狀態||Published - 1 3月 2022|