A simple pumpfree HEPG2 liver cells spheroid amalgamation platform via gravity driving force

Shih Mo Yang, Chun Yen Lin, Shilpa Sivashankar, Srinivasu Valagerahally Puttaswamy, Hwan You Chang, Long Hsu, Cheng Hsien Liu

研究成果: Conference contribution同行評審

摘要

We present a simple pumpless microfluidics design to pair 3D artificial liver tissue. This design concept could pair two or more 3D spheroids with green approach for investigating artificial tissue cell-cell interaction. All the operation process, HepG2 cells spheroid formation and pairing, is accomplished on this chip within two days. The gravity force is applied to drive the 250μm diameter liver spheroid moving and no external power is required. Avoiding the hydrodynamic pressure damage for the assembled HepG2 cells caused by syringe pump is its unique advantage. This mimetic liver labchip is developed to hepatotoxicity assay with 3D liver tissue in the future.

原文English
主出版物標題15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
頁面1017-1019
頁數3
出版狀態Published - 1 12月 2011
事件15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 - Seattle, WA, United States
持續時間: 2 10月 20116 10月 2011

出版系列

名字15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
2

Conference

Conference15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
國家/地區United States
城市Seattle, WA
期間2/10/116/10/11

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