Keyphrases
Potential Therapeutics
100%
Neuroprotection
100%
Selective Inhibitor
100%
Transgenic Mouse Model
100%
Huntington's Disease
100%
NLRP3 Inflammasome
100%
CAG Repeat
37%
Huntingtin
37%
Beneficial Effects
25%
Interleukin-1β
25%
Oral Administration
25%
Neuroinflammation
25%
Neurodegenerative Diseases
25%
NOD-like Receptor Protein 3 (NLRP3)
25%
Therapeutic Potential
12%
Extended Life
12%
Highly Selective
12%
Biological Function
12%
Reactive Oxygen Species Production
12%
Transgenic
12%
Littermate
12%
Cellular Proteins
12%
Postsynaptic Density Protein 95 (PSD-95)
12%
Microglia
12%
Astrocytes
12%
Alzheimer's Disease
12%
Neurotoxicity
12%
Normal Function
12%
Interleukin-18 (IL-18)
12%
Brain Cells
12%
Motor Function
12%
Polyglutamine
12%
Neuronal Survival
12%
Protein mutants
12%
Exon 1
12%
Striatum
12%
Motor Dysfunction
12%
Cellular Machinery
12%
LRR Domain
12%
PYD Domain
12%
Caspase-1
12%
NACHT Domain
12%
Mutant Huntingtin
12%
NeuN
12%
Small Molecule Inhibitors
12%
Biochemistry, Genetics and Molecular Biology
Transgenic Mouse
100%
Mouse Model
100%
NLRP3 Inflammasome
100%
Huntingtin
80%
CAG Repeat
60%
Lifespan
40%
Interleukin-1
40%
Body Weight
40%
NLR Family Pyrin Domain containing 3
40%
Mutant Protein
20%
Wild Type
20%
Exon
20%
Upregulation
20%
Biological Functions
20%
Transgenics
20%
Small Molecule
20%
Astrocyte
20%
Pyrin Domain
20%
NeuN
20%
Microglia
20%
Interleukin 18
20%
Caspase 1
20%
LRR Domain
20%
Motor Performance
20%
NACHT Domain
20%
Pharmacology, Toxicology and Pharmaceutical Science
Transgenic Mouse
100%
Mouse Model
100%
Huntington Chorea
100%
Neuroprotection
100%
Inflammasome
100%
Huntingtin
50%
Nervous System Inflammation
25%
Diseases
25%
Cell Protein
12%
Reactive Oxygen Metabolite
12%
Mutant Protein
12%
Degenerative Disease
12%
Alzheimer's Disease
12%
Interleukin 18
12%
Polyglutamine
12%
Motor Dysfunction
12%
Interleukin 1beta Converting Enzyme
12%
Cryopyrin
12%
Disks Large Homolog 4
12%
Neuroscience
Inflammasome
100%
Neuroprotection
100%
Huntington's Disease
100%
Huntingtin
50%
CAG Repeat
37%
Neurodegenerative Disorder
25%
Reactive Oxygen Species
12%
Cell Protein
12%
Microglia
12%
Astrocyte
12%
Alzheimer's Disease
12%
Mutant Protein
12%
Stereotypic Movement Disorder
12%
Exon
12%
Striatum
12%
Disks Large Homolog 4
12%
NeuN
12%
Polyglutamine
12%
Interleukin 18
12%
Caspase 1
12%