A selective glucose sensor: The cooperative effect of monoboronic acid-modified poly(amidoamine) dendrimers

Ching Hua Tsai; Yi Hsuan Tang; Hui Ting Chen; Yi Wen Yao; Tun Cheng Chien; Chai Lin Kao

doi:10.1039/c8cc00914g

A selective glucose sensor: The cooperative effect of monoboronic acid-modified poly(amidoamine) dendrimers

Ching Hua Tsai, Yi Hsuan Tang, Hui Ting Chen, Yi Wen Yao, Tun Cheng Chien^*, Chai Lin Kao

^*此作品的通信作者

藥學系

研究成果: Article › 同行評審

12 引文斯高帕斯（Scopus）

摘要

Selective glucose binding was identified through five generations of monoboronic acid-functionalized PAMAM dendrimers. The best selectivity obtained when using G3 dendrimers (1b) generated 71.1, 94.9, and 1309 times stronger binding than when using galactose, fructose, and lactose, respectively. Further experiments using dendrimer analogues and glucose derivatives suggested that two nearby monoboronic acids cooperatively bound one glucose.

原文	English
頁（從 - 到）	4577-4580
頁數	4
期刊	Chemical Communications
卷	54
發行號	36
DOIs	https://doi.org/10.1039/c8cc00914g
出版狀態	Published - 2018

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10.1039/c8cc00914g

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abstract = "Selective glucose binding was identified through five generations of monoboronic acid-functionalized PAMAM dendrimers. The best selectivity obtained when using G3 dendrimers (1b) generated 71.1, 94.9, and 1309 times stronger binding than when using galactose, fructose, and lactose, respectively. Further experiments using dendrimer analogues and glucose derivatives suggested that two nearby monoboronic acids cooperatively bound one glucose.",

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AU - Tsai, Ching Hua

AU - Tang, Yi Hsuan

AU - Chen, Hui Ting

AU - Yao, Yi Wen

AU - Chien, Tun Cheng

AU - Kao, Chai Lin

PY - 2018

Y1 - 2018

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AB - Selective glucose binding was identified through five generations of monoboronic acid-functionalized PAMAM dendrimers. The best selectivity obtained when using G3 dendrimers (1b) generated 71.1, 94.9, and 1309 times stronger binding than when using galactose, fructose, and lactose, respectively. Further experiments using dendrimer analogues and glucose derivatives suggested that two nearby monoboronic acids cooperatively bound one glucose.

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JO - Chemical Communications

JF - Chemical Communications

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ER -

A selective glucose sensor: The cooperative effect of monoboronic acid-modified poly(amidoamine) dendrimers

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