A phased-array stimulator system for studying planar and curved cardiac activation wavefronts

Rashida A. Abbas, Shien-Fong Lin, David Mashburn, Junkai Xu, John P. Wikswo*

*此作品的通信作者

研究成果: Article同行評審

1 引文 斯高帕斯(Scopus)

摘要

Wavefront propagation in cardiac tissue is affected greatly by the geometry of the wavefront. We describe a computer-controlled stimulator system that creates reproducible wavefronts of a predetermined shape and orientation for the investigation of the effects of wavefront geometry. We conducted demonstration experiments on isolated perfused rabbit hearts, which were stained with the voltage-sensitive dye, di-4-ANEPPS. The wavefronts were imaged using a laser and a charge-coupled device (CCD) camera. The stimulator and imaging systems have been used to characterize the relationship between wavefront velocity and fiber orientation. This approach has potential applications in investigating curvature effects, testing numerical models of cardiac tissue, and creating complex wavefronts using one-, two-, or three-dimensional electrode arrays.

原文English
頁(從 - 到)222-229
頁數8
期刊IEEE Transactions on Biomedical Engineering
55
發行號1
DOIs
出版狀態Published - 1 一月 2008

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