TY - GEN
T1 - A Pattern-Control Digital Microfluidic Bio-Chip for Fast Thermal Cycle in Nucleic Acid Amplification Tests
AU - Chan, Yun Sheng
AU - Diao, Jiajie
AU - Lee, Chen Yi
N1 - Publisher Copyright:
© 2023 IEEE.
PY - 2023
Y1 - 2023
N2 - A pattern-control digital biochip is proposed for fast medical tests. With integrated circuit modules in each basic element, also known as micro-electrode, this biochip can achieve digital microfluidic operations, capacitive sensing, and thermal cycle via different control patterns. As a result, bio-protocols can be derived from target biomedical tests to reach better test accuracy on the proposed chip. For the mentioned fast medical tests, samples/reagents can be identified first by capacitive sensing, followed by microfluidic and thermal cycle operations. Preliminary measurements show that heating/cooling rate of 5°C/sec can be achieved and demonstrate each thermal cycle (95→55→72) for polymerase chain reaction (PCR) can be completed in less than 20 seconds with power consumption of 256-444 uW per micro-electrode while dealing with nano-liter samples. This implies both test time and power consumption per sample test can be further improved, making our proposed biochip very suitable for point-of-care test (POCT) applications.
AB - A pattern-control digital biochip is proposed for fast medical tests. With integrated circuit modules in each basic element, also known as micro-electrode, this biochip can achieve digital microfluidic operations, capacitive sensing, and thermal cycle via different control patterns. As a result, bio-protocols can be derived from target biomedical tests to reach better test accuracy on the proposed chip. For the mentioned fast medical tests, samples/reagents can be identified first by capacitive sensing, followed by microfluidic and thermal cycle operations. Preliminary measurements show that heating/cooling rate of 5°C/sec can be achieved and demonstrate each thermal cycle (95→55→72) for polymerase chain reaction (PCR) can be completed in less than 20 seconds with power consumption of 256-444 uW per micro-electrode while dealing with nano-liter samples. This implies both test time and power consumption per sample test can be further improved, making our proposed biochip very suitable for point-of-care test (POCT) applications.
KW - DMFB
KW - MEA
KW - MEDA
KW - Programmable
UR - http://www.scopus.com/inward/record.url?scp=85167725591&partnerID=8YFLogxK
U2 - 10.1109/ISCAS46773.2023.10181466
DO - 10.1109/ISCAS46773.2023.10181466
M3 - Conference contribution
AN - SCOPUS:85167725591
T3 - Proceedings - IEEE International Symposium on Circuits and Systems
BT - ISCAS 2023 - 56th IEEE International Symposium on Circuits and Systems, Proceedings
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 56th IEEE International Symposium on Circuits and Systems, ISCAS 2023
Y2 - 21 May 2023 through 25 May 2023
ER -