A novel ultrasound-triggered drug vehicle with multimodal imaging functionality

Tse Ying Liu*, Meng Yu Wu, Meng Hsuan Lin, Feng Yi Yang


研究成果: Article同行評審

23 引文 斯高帕斯(Scopus)


A novel remotely triggered drug vehicle having multimodal imaging functionality was developed. It exhibits magnetic resonance (MR) imaging, ultrasound (US) imaging, encapsulation of a hydrophobic agent and US-triggered release behavior. Lipophilic superparamagnetic iron oxide (SPIO) nanoparticles were self-assembled with an amphiphilic chitosan derivative, carboxymethyl hexanoyl chitosan (CHC), to form superparamagnetic CHC/SPIO micelles and then loaded with camptothecin (a hydrophobic anticancer agent). The superparamagnetic micelles were then conjugated with albumin-based microbubbles (MBs) to form superparamagnetic micelle-decorated MBs (CHC/SPIO-decorated MBs). The albumin MBs and CHC/SPIO-decorated MBs both demonstrated in vitro concentration- dependent US imaging contrast. Interestingly, the in vitro US contrast was enhanced by decoration. In vivo US images showed that the B-mode contrast of the proposed vehicles could be clearly observed in the veins and arteries of Sprague-Dawley rats. Moreover, the proposed vehicle exhibited significant US-triggered release behavior under therapeutic US sonication at a frequency of 1 MHz and power density of 2.4 W cm-2 for 30 min. However, similar behavior was not observed under diagnostic US bombardment at a frequency of 12 MHz and mechanical index of 0.5. On the other hand, in vitro MR images of the CHC/SPIO-micelle-decorated MBs also revealed a significant concentration- dependent T2 (spin-spin relaxation time) contrast due to their decoration with superparamagnetic micelles. Most importantly, the r*2-r2 value of the CHC/SPIO-decorated MBs decreased after therapeutic US bombardment for 30 min. This might be considered as an index to probe destruction of the drug-loaded CHC/SPIO micelles.

頁(從 - 到)5453-5463
期刊Acta Biomaterialia
出版狀態Published - 3月 2013


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