A novel Aurora-A-mediated phosphorylation of p53 inhibits its interaction with MDM2

Keyphrases

• Phosphorylation 100%
• Aurora A 100%
• Murine Double Minute 2 (MDM2) 100%
• Co-immunoprecipitation (co-IP) 18%
• Phosphorylation Sites 18%
• Phosphopeptides 18%
• Functional Consequences 18%
• Protein Stability 9%
• Mass Spectrometry 9%
• Human Cancer 9%
• Michael Addition 9%
• Protein-protein Interaction 9%
• Interacting Proteins 9%
• Transactivation 9%
• Reporter Assay 9%
• Phosphorylated Protein 9%
• Trypsin 9%
• Phosphate 9%
• Cancer Biology 9%
• Western Blot Assay 9%
• Whole Genome Amplification 9%
• Phos-tag SDS-PAGE 9%
• In Vitro Phosphorylation 9%
• P53 Phosphorylation 9%
• Alanine mutation 9%
• Immobilized Metal Affinity Chromatography 9%

Biochemistry, Genetics and Molecular Biology

• P53 100%
• Immunoprecipitation 15%
• Protein-Protein Interaction 15%
• Phosphopeptide 15%
• Genetics 7%
• Protein Stability 7%
• Mass Spectrometry 7%
• Polyacrylamide Gel Electrophoresis 7%
• Western Blot 7%
• Transactivation 7%
• Phosphoprotein 7%
• Aurora A Kinase 7%
• Michael Addition 7%
• Serine 7%
• Alanine 7%
• Affinity Chromatography 7%

Pharmacology, Toxicology and Pharmaceutical Science

• Protein P53 100%
• Immunoprecipitation 15%
• Phosphopeptide 15%
• Malignant Neoplasm 7%
• Western Blot 7%
• Polyacrylamide Gel Electrophoresis 7%
• Serine 7%
• Elimination 7%
• Alanine 7%
• Phosphoprotein 7%
• Aurora A Kinase 7%