@article{c36ef1dce74946fd8c034c890f960ce5,
title = "A novel anabolic agent: A simvastatin analogue without HMG-CoA reductase inhibitory activity",
abstract = "For the first time, structural information regarding the role of simvastatin in bone anabolism is described, and a bone-specific statin is introduced. Polyaspartate-conjugated simvastatin was synthesized by solid-phase synthesis with the assistance of microwave irradiation. It displays significant bone targeting and bone formation with less toxicity than simvastatin.",
author = "Hsieh, {Kuang Chan} and Kao, {Chai Lin} and Feng, {Chien Wei} and Wen, {Zhi Hong} and Chang, {Hsin Fang} and Chuang, {Shu Chun} and Wang, {Gwo Jaw} and Ho, {Mei Ling} and Wu, {Shou Mei} and Chang, {Je Ken} and Chen, {Hui Ting}",
note = "Publisher Copyright: {\textcopyright} 2014 American Chemical Society.",
year = "2014",
month = sep,
day = "5",
doi = "10.1021/ol501486b",
language = "English",
volume = "16",
pages = "4376--4379",
journal = "Organic Letters",
issn = "1523-7060",
publisher = "American Chemical Society",
number = "17",
}