A new subtype of progenitor cell in the mouse embryonic neocortex

Xiaoqun Wang*, Jin Wu Tsai, Bridget Lamonica, Arnold R. Kriegstein


研究成果: Article同行評審

358 引文 斯高帕斯(Scopus)


A hallmark of mammalian brain evolution is cortical expansion, which reflects an increase in the number of cortical neurons established by the progenitor cell subtypes present and the number of their neurogenic divisions. Recent studies have revealed a new class of radial glia-like (oRG) progenitor cells in the human brain, which reside in the outer subventricular zone. Expansion of the subventricular zone and appearance of oRG cells may have been essential evolutionary steps leading from lissencephalic to gyrencephalic neocortex. Here we show that oRG-like progenitor cells are present in the mouse embryonic neocortex. They arise from asymmetric divisions of radial glia and undergo self-renewing asymmetric divisions to generate neurons. Moreover, mouse oRG cells undergo mitotic somal translocation whereby centrosome movement into the basal process during interphase precedes nuclear translocation. Our finding of oRG cells in the developing rodent brain fills a gap in our understanding of neocortical expansion.

頁(從 - 到)555-562
期刊Nature Neuroscience
出版狀態Published - 5月 2011


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