TY - JOUR
T1 - A New Homoisoflavonoid and Anti-Inflammatory Constituents from Polygonatum alte-lobatum
AU - Cheng, Chieh Yang
AU - Huang, Chien Ming
AU - Lin, Chien Liang
AU - Chang, Tsung Hsien
AU - Sung, Ping Jyun
AU - Cheng, Ming Jen
AU - Chen, Jih Jung
N1 - Publisher Copyright:
© Springer Science+Business Media, LLC, part of Springer Nature 2024.
PY - 2024/5
Y1 - 2024/5
N2 - A new homoisoflavonoid, (R)-3-(2,4-dihydroxybenzyl)-5,7-dihydroxy-8-methoxychroman-4-one (1), has been isolated from the rhizomes of Polygonatum alte-lobatum, together with seven known compounds (2–8). The structure of the new compound 1 was determined through spectroscopic and MS analyses. Among the isolated compounds, compounds 1, 3, 5, and 6 showed potent inhibition with IC50 values of 18.04 ± 2.14, 19.87 ± 2.70, 16.88 ± 1.35, and 18.50 ± 1.52 μM, respectively, against LPS-induced NO generation.
AB - A new homoisoflavonoid, (R)-3-(2,4-dihydroxybenzyl)-5,7-dihydroxy-8-methoxychroman-4-one (1), has been isolated from the rhizomes of Polygonatum alte-lobatum, together with seven known compounds (2–8). The structure of the new compound 1 was determined through spectroscopic and MS analyses. Among the isolated compounds, compounds 1, 3, 5, and 6 showed potent inhibition with IC50 values of 18.04 ± 2.14, 19.87 ± 2.70, 16.88 ± 1.35, and 18.50 ± 1.52 μM, respectively, against LPS-induced NO generation.
KW - anti-inflammatory activity
KW - Asparagaceae
KW - homoisoflavonoid
KW - Polygonatumalte-lobatum
KW - rhizomes
UR - http://www.scopus.com/inward/record.url?scp=85193733263&partnerID=8YFLogxK
U2 - 10.1007/s10600-024-04343-1
DO - 10.1007/s10600-024-04343-1
M3 - Article
AN - SCOPUS:85193733263
SN - 0009-3130
VL - 60
SP - 428
EP - 431
JO - Chemistry of Natural Compounds
JF - Chemistry of Natural Compounds
IS - 3
ER -