A New 2H-Pyran-2-One Derivative and Anti-Inflammatory Constituents from Alpinia pricei var. pricei

Chu Wen Kuo, Chien Ming Huang, Hsueh Yang Huang, Tsung Hsien Chang, Chia Ching Liaw, Ping Jyun Sung, Yi Cheng Chu, Ming Jen Cheng*, Hui Ming Chen*, Jih Jung Chen*

*此作品的通信作者

研究成果: Article同行評審

摘要

A new 2H-pyran-2-one derivative, 4-hydroxy-6-(3-methoxyphenethyl)-2H-pyran-2-one (1), has been isolated from the rhizomes of Alpinia pricei var. pricei, together with six known compounds, dihydro-5,6-dehydrokawain (2), 5,6-dehydrokawain (3), 1,7-bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one (4), bisdemethoxycurcumin (5), apigenin (6), and kaempferol (7). The structure of new compound 1 was determined through spectroscopic and MS analyses. Among the isolates, 1,7-bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one (4), bisdemethoxycurcumin (5), apigenin (6), and kaempferol (7) showed potent inhibition with IC50 values of 25.47 ± 2.04, 22.39 ± 1.83, 14.60 ± 0.87, and 18.44 ± 1.50 μM, respectively, against LPS-induced NO generation.

原文English
頁(從 - 到)662-665
頁數4
期刊Chemistry of Natural Compounds
59
發行號4
DOIs
出版狀態Published - 7月 2023

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