A lytic viral long noncoding RNA modulates the function of a latent protein

Mel Campbell, Kevin Y. Kim, Pei Ching Chang, Steve Huerta, Bogdan Shevchenko, Don Hong Wang, Chie Izumiya, Hsing Jien Kung, Yoshihiro Izumiya*

*此作品的通信作者

研究成果: Article同行評審

58 引文 斯高帕斯(Scopus)

摘要

Latent Kaposi's sarcoma-associated herpesvirus (KSHV) episomes are coated with viral latency-associated nuclear antigen (LANA). In contrast, LANA rapidly disassociates from episomes during reactivation. Lytic KSHV expresses polyadenylated nuclear RNA (PAN RNA), a long noncoding RNA (lncRNA). We report that PAN RNA promotes LANA-episome disassociation through an interaction with LANA which facilitates LANA sequestration away from KSHV episomes during reactivation. These findings suggest that KSHV may have evolved an RNA aptamer to regulate latent protein function.

原文English
頁(從 - 到)1843-1848
頁數6
期刊Journal of Virology
88
發行號3
DOIs
出版狀態Published - 2月 2014

指紋

深入研究「A lytic viral long noncoding RNA modulates the function of a latent protein」主題。共同形成了獨特的指紋。

引用此