A 460 800 Pixels CMOS Capacitive Sensor Array With Programmable Fusion Pixels and Noise Canceling for Life Science Applications

Lin Hung Lai; Wen Yue Lin; Yu Wei Lu; Heng Yu Lui; Shinsuke Yoshida; Shih Hwa Chiou; Chen Yi Lee

doi:10.1109/TCSII.2023.3261445

A 460 800 Pixels CMOS Capacitive Sensor Array With Programmable Fusion Pixels and Noise Canceling for Life Science Applications

Lin Hung Lai^*, Wen Yue Lin, Yu Wei Lu, Heng Yu Lui, Shinsuke Yoshida, Shih Hwa Chiou, Chen Yi Lee

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4 引文斯高帕斯（Scopus）

摘要

Capacitive sensor array (CSA) plays an important role in life science applications, such as cell monitoring, DNA detection, or drug screening. This brief presents a 480×960 time-sharing TDC (ts-TDC) architecture of global shutter CSA. It provides an opportunity to merge interfacing, read-out and sampling circuits in pixel and dynamically adjust the electrode size according to the characteristic of biosample. Each pixel size is within 2.25× 2.25μ m2. The sensitivity of the proposed CSA is 6.896 codes/fF, and 43 fps can be adopted for real-time monitoring. Experiment results show that noise canceling significantly improves the sensing performance. Moreover, sensitivity can be optimized by given fusion-pixel pattern, making our proposal very flexible and suitable for cell biology applications and personalized medicine.

原文	English
頁（從 - 到）	1734-1738
頁數	5
期刊	IEEE Transactions on Circuits and Systems I: Regular Papers
卷	70
發行號	5
DOIs	https://doi.org/10.1109/TCSII.2023.3261445
出版狀態	Published - 1 5月 2023

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10.1109/TCSII.2023.3261445

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title = "A 460 800 Pixels CMOS Capacitive Sensor Array With Programmable Fusion Pixels and Noise Canceling for Life Science Applications",

abstract = "Capacitive sensor array (CSA) plays an important role in life science applications, such as cell monitoring, DNA detection, or drug screening. This brief presents a 480×960 time-sharing TDC (ts-TDC) architecture of global shutter CSA. It provides an opportunity to merge interfacing, read-out and sampling circuits in pixel and dynamically adjust the electrode size according to the characteristic of biosample. Each pixel size is within 2.25× 2.25μ m2. The sensitivity of the proposed CSA is 6.896 codes/fF, and 43 fps can be adopted for real-time monitoring. Experiment results show that noise canceling significantly improves the sensing performance. Moreover, sensitivity can be optimized by given fusion-pixel pattern, making our proposal very flexible and suitable for cell biology applications and personalized medicine.",

keywords = "CMOS lab-on-chip, capacitance sensor array, fusion pixels, high throughput, ts-TDC",

author = "Lai, {Lin Hung} and Lin, {Wen Yue} and Lu, {Yu Wei} and Lui, {Heng Yu} and Shinsuke Yoshida and Chiou, {Shih Hwa} and Lee, {Chen Yi}",

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AU - Lai, Lin Hung

AU - Lin, Wen Yue

AU - Lu, Yu Wei

AU - Lui, Heng Yu

AU - Yoshida, Shinsuke

AU - Chiou, Shih Hwa

AU - Lee, Chen Yi

PY - 2023/5/1

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KW - CMOS lab-on-chip

KW - capacitance sensor array

KW - fusion pixels

KW - high throughput

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A 460 800 Pixels CMOS Capacitive Sensor Array With Programmable Fusion Pixels and Noise Canceling for Life Science Applications

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