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Keyphrases
Prostate Cancer Cells
100%
Cyclooxygenase-2
100%
Celecoxib
100%
AKT Pathway
100%
PDK1
100%
Akt Activation
50%
High Concentration
12%
Induced Apoptosis
12%
Independent Pathway
12%
IC50
12%
PC-3 Cells
12%
PC-3
12%
Relative Contribution
12%
Marginal Impact
12%
Antiproliferative Activity
12%
Inhibitory Activity
12%
IC50 Value
12%
In Vivo Efficacy
12%
Xenograft Tumor
12%
Trifluoromethyl
12%
Dephosphorylation
12%
Pyrazol
12%
Tumor Samples
12%
Antineoplastic Agents
12%
Differential Reduction
12%
Benzenesulfonamide
12%
Xenograft Tumor Growth
12%
Protein Phosphatase 2A (PP2A)
12%
G1 Arrest
12%
Celecoxib Analogs
12%
Phospho-Akt
12%
Relative Potency
12%
Biochemistry, Genetics and Molecular Biology
Cancer Cell
100%
Cyclooxygenase
100%
Akt Signaling
100%
Phosphoinositide-Dependent Kinase-1
100%
Celecoxib
100%
Protein Kinase B
66%
IC50
22%
Tumor Progression
11%
Phosphoprotein Phosphatase
11%
Dephosphorylation
11%
Independent Pathway
11%
G1/S Transition
11%
Antiproliferative Activity
11%
Programmed Cell Death
11%
Pharmacology, Toxicology and Pharmaceutical Science
Prostate Cancer
100%
Celecoxib
100%
Cyclooxygenase 2
100%
Protein Kinase B
100%
Phosphoinositide Dependent Protein Kinase 1
100%
IC50
22%
Neoplasm
22%
Tumor Growth
11%
Phosphoprotein Phosphatase 2A
11%
Benzenesulfonamide
11%
Neuroscience
Cyclooxygenase 2
100%
Akt Signaling
100%
Phosphoinositide-Dependent Kinase-1
100%
Celecoxib
100%
Protein Kinase B
66%
In Vitro
22%
Dephosphorylation
11%
Phosphoprotein Phosphatase 2A
11%
G1 Phase Cell Cycle Checkpoint
11%
Programmed Cell Death
11%
Immunology and Microbiology
Cancer Cell
100%
Akt Signaling
100%
Cyclooxygenase
100%
Xenograft
33%
IC50
33%
G1 Phase Cell Cycle Checkpoint
16%
Antiproliferative Activity
16%
Dephosphorylation
16%
Programmed Cell Death
16%