2-Methoxyestradiol attenuates phosphatidylinositol 3-kinase/Akt pathway-mediated metastasis of gastric cancer

Keyphrases

• Metastasis 100%
• Phosphoinositide 3-kinase (PI3K) 100%
• Gastric Cancer 100%
• 2-methoxyestradiol 100%
• Phosphorylated Akt 57%
• Attenuation 28%
• Invasiveness 28%
• Akt Activation 28%
• Antimetastatic Effect 28%
• Tumor 14%
• High Concentration 14%
• Molecular Mechanism 14%
• Phosphorylation 14%
• Overexpression 14%
• Akt Phosphorylation 14%
• Cancer Cell Proliferation 14%
• Tumor Stage 14%
• Migration Inhibition 14%
• In Vitro Study 14%
• AKT1 14%
• PI3K-Akt Pathway 14%
• Immunohistochemistry 14%
• Gastric Cancer Cells 14%
• Cancer Cell Invasiveness 14%
• Tumor Angiogenesis 14%
• Gastric Cancer Cell Lines 14%
• Gastric Cancer Patients 14%
• Tumor Proliferation 14%
• Estradiol-17 14%
• Metastatic Gastric Cancer 14%
• Gastric Metastasis 14%
• G2-M Cell Cycle Arrest 14%
• Stage Progression 14%

Biochemistry, Genetics and Molecular Biology

• Phosphoinositide 3-Kinase 100%
• Protein Kinase B 100%
• 2-Methoxyestradiol 100%
• Cancer Cell 27%
• Cancer Staging 9%
• Cell Cycle Arrest 9%
• Tumor Progression 9%
• Low Drug Dose 9%
• Cell Proliferation 9%
• In Vitro Study 9%
• Cell Invasion 9%
• Angiogenesis 9%
• Metabolite 9%
• Cell Cycle Checkpoint 9%
• Estradiol 9%

Pharmacology, Toxicology and Pharmaceutical Science

• Phosphatidylinositol 3 Kinase 100%
• Protein Kinase B 100%
• Abdominal Cancer 100%
• Recurrent Disease 9%
• Malignant Neoplasm 9%
• Neoplasm 9%
• Cancer Staging 9%
• Metastasis 9%
• Tumor Growth 9%
• Diethylstilbestrol 9%