ε4 allele of apolipoprotein E increases risk of Alzheimer's disease in a Chinese population

C. J. Hong; T. Y. Liu; H. C. Liu; S. J. Wang; J. L. Fuh; C. W. Chi; K. Y. Lee; C. B. Sim

doi:10.1212/WNL.46.6.1749

ε4 allele of apolipoprotein E increases risk of Alzheimer's disease in a Chinese population

C. J. Hong, T. Y. Liu, H. C. Liu^*, S. J. Wang, J. L. Fuh, C. W. Chi, K. Y. Lee, C. B. Sim

^*此作品的通信作者

醫學系

研究成果: Article › 同行評審

59 引文斯高帕斯（Scopus）

摘要

We examined the apolipoprotein E genotype in 56 Chinese patients with late-onset sporadic Alzheimer's disease (AD) and 57 Chinese control subjects of similar age. The frequency of ε4 in the AD group was significantly higher than that in the control group (23.2% versus 7.9%, p = 0.003). The odds ratio for AD in individuals with either one or two ε4 was 2.96 (95% CI 1.11 to 8.03). The linear trend for AD in proportion to alleles of ε4 was also significant (χ² = 8.2, p = 0.004). Our results support the association between ε4 and AD in the Chinese.

原文	English
頁（從 - 到）	1749-1751
頁數	3
期刊	Neurology
卷	46
發行號	6
DOIs	https://doi.org/10.1212/WNL.46.6.1749
出版狀態	Published - 6月 1996

存取文件

10.1212/WNL.46.6.1749

其它文件與鏈接

Link to publication in Scopus

引用此

@article{758dcdf915cd4a8382245c02b2f9cf7f,

title = "ε4 allele of apolipoprotein E increases risk of Alzheimer's disease in a Chinese population",

abstract = "We examined the apolipoprotein E genotype in 56 Chinese patients with late-onset sporadic Alzheimer's disease (AD) and 57 Chinese control subjects of similar age. The frequency of ε4 in the AD group was significantly higher than that in the control group (23.2% versus 7.9%, p = 0.003). The odds ratio for AD in individuals with either one or two ε4 was 2.96 (95% CI 1.11 to 8.03). The linear trend for AD in proportion to alleles of ε4 was also significant (χ2 = 8.2, p = 0.004). Our results support the association between ε4 and AD in the Chinese.",

author = "Hong, {C. J.} and Liu, {T. Y.} and Liu, {H. C.} and Wang, {S. J.} and Fuh, {J. L.} and Chi, {C. W.} and Lee, {K. Y.} and Sim, {C. B.}",

year = "1996",

month = jun,

doi = "10.1212/WNL.46.6.1749",

language = "English",

volume = "46",

pages = "1749--1751",

journal = "Neurology",

issn = "0028-3878",

publisher = "Lippincott Williams and Wilkins",

number = "6",

}

TY - JOUR

T1 - ε4 allele of apolipoprotein E increases risk of Alzheimer's disease in a Chinese population

AU - Hong, C. J.

AU - Liu, T. Y.

AU - Liu, H. C.

AU - Wang, S. J.

AU - Fuh, J. L.

AU - Chi, C. W.

AU - Lee, K. Y.

AU - Sim, C. B.

PY - 1996/6

Y1 - 1996/6

N2 - We examined the apolipoprotein E genotype in 56 Chinese patients with late-onset sporadic Alzheimer's disease (AD) and 57 Chinese control subjects of similar age. The frequency of ε4 in the AD group was significantly higher than that in the control group (23.2% versus 7.9%, p = 0.003). The odds ratio for AD in individuals with either one or two ε4 was 2.96 (95% CI 1.11 to 8.03). The linear trend for AD in proportion to alleles of ε4 was also significant (χ2 = 8.2, p = 0.004). Our results support the association between ε4 and AD in the Chinese.

AB - We examined the apolipoprotein E genotype in 56 Chinese patients with late-onset sporadic Alzheimer's disease (AD) and 57 Chinese control subjects of similar age. The frequency of ε4 in the AD group was significantly higher than that in the control group (23.2% versus 7.9%, p = 0.003). The odds ratio for AD in individuals with either one or two ε4 was 2.96 (95% CI 1.11 to 8.03). The linear trend for AD in proportion to alleles of ε4 was also significant (χ2 = 8.2, p = 0.004). Our results support the association between ε4 and AD in the Chinese.

UR - http://www.scopus.com/inward/record.url?scp=0029665514&partnerID=8YFLogxK

U2 - 10.1212/WNL.46.6.1749

DO - 10.1212/WNL.46.6.1749

M3 - Article

C2 - 8649585

AN - SCOPUS:0029665514

SN - 0028-3878

VL - 46

SP - 1749

EP - 1751

JO - Neurology

JF - Neurology

IS - 6

ER -

ε4 allele of apolipoprotein E increases risk of Alzheimer's disease in a Chinese population

摘要

存取文件

其它文件與鏈接

指紋

引用此