ε4 allele of apolipoprotein E increases risk of Alzheimer's disease in a Chinese population

C. J. Hong, T. Y. Liu, H. C. Liu*, S. J. Wang, J. L. Fuh, C. W. Chi, K. Y. Lee, C. B. Sim

*此作品的通信作者

研究成果: Article同行評審

59 引文 斯高帕斯(Scopus)

摘要

We examined the apolipoprotein E genotype in 56 Chinese patients with late-onset sporadic Alzheimer's disease (AD) and 57 Chinese control subjects of similar age. The frequency of ε4 in the AD group was significantly higher than that in the control group (23.2% versus 7.9%, p = 0.003). The odds ratio for AD in individuals with either one or two ε4 was 2.96 (95% CI 1.11 to 8.03). The linear trend for AD in proportion to alleles of ε4 was also significant (χ2 = 8.2, p = 0.004). Our results support the association between ε4 and AD in the Chinese.

原文English
頁(從 - 到)1749-1751
頁數3
期刊Neurology
46
發行號6
DOIs
出版狀態Published - 6月 1996

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