Yu-Chan Chang

2024

ALDOA coordinates PDE3A through the β-catenin/ID3 axis to stimulate cancer metastasis and M2 polarization in lung cancer with EGFR mutations

Yeh, C. Y., Cai, H. Y., Kuo, H. H., Lin, Y. Y., He, Z. J., Cheng, H. C., Yang, C. J., Huang, C. Y. F. & Chang, Y. C., 12 2月 2024, 於: Biochemical and Biophysical Research Communications. 696, 149489.

研究成果: Article › 同行評審

CD47-mediated immune evasion in early-stage lung cancer progression

Chuang, C. H., Zhen, Y. Y., Ma, J. Y., Lee, T. H., Hung, H. Y., Wu, C. C., Wang, P. H., Huang, C. T., Huang, M. S., Hsiao, M., Lee, Y. R., Huang, C. Y. F., Chang, Y. C. & Yang, C. J., 6 8月 2024, 於: Biochemical and Biophysical Research Communications. 720, 150066.

研究成果: Article › 同行評審

Dawn era for revisited cancer therapy by innate immune system and immune checkpoint inhibitors

Kim, H. D., Yeh, C. Y., Chang, Y. C. & Kim, C. H., 3月 2024, 於: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1870, 3, 167019.

研究成果: Review article › 同行評審

Magnetically Guided Theranostics: Novel Nanotubular Magnetic Resonance Imaging Contrast System Using Halloysite Nanotubes Embedded with Iron–Platinum Nanoparticles for Hepatocellular Carcinoma Treatment

Chan, M. H., Lee, C. Y., Li, C. H., Chang, Y. C., Wei, D. H. & Hsiao, M., 8月 2024, 於: Small Structures. 5, 8, 2300526.

研究成果: Article › 同行評審

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PPAR-γ agonists reactivate the ALDOC-NR2F1 axis to enhance sensitivity to temozolomide and suppress glioblastoma progression

Chang, Y. C., Chan, M. H., Li, C. H., Chen, C. L., Tsai, W. C. & Hsiao, M., 12月 2024, 於: Cell Communication and Signaling. 22, 1, 266.

研究成果: Article › 同行評審

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Recent advances in near-infrared I/II persistent luminescent nanoparticles for biosensing and bioimaging in cancer analysis

Chan, M. H. & Chang, Y. C., 7月 2024, 於: Analytical and Bioanalytical Chemistry. 416, 17, p. 3887-3905 19 p.

研究成果: Review article › 同行評審

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2023

A G-quadruplex stabilizer, CX-5461 combined with two immune checkpoint inhibitors enhances in vivo therapeutic efficacy by increasing PD-L1 expression in colorectal cancer

Chung, S. Y., Chang, Y. C., Hsu, D. S. S., Hung, Y. C., Lu, M. L., Hung, Y. P., Chiang, N. J., Yeh, C. N., Hsiao, M., Soong, J., Su, Y. & Chen, M. H., 1月 2023, 於: Neoplasia. 35, 100856.

研究成果: Article › 同行評審

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6 引文斯高帕斯（Scopus）

Editorial: Metabolism-based omics integrations, biosensors, and molecular mechanisms in human cancers

Yang, Y. F., Tsai, K. W., Chang, P. M. H. & Chang, Y. C., 2023, 於: Frontiers in Oncology. 13, 1159545.

研究成果: Editorial

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Glucose transporter 4: Insulin response mastermind, glycolysis catalyst and treatment direction for cancer progression

Chang, Y. C., Chan, M. H., Yang, Y. F., Li, C. H. & Hsiao, M., 1 6月 2023, 於: Cancer Letters. 563, 216179.

研究成果: Review article › 同行評審

15 引文斯高帕斯（Scopus）

Gold Nanoparticles as a Biosensor for Cancer Biomarker Determination

Li, C. H., Chan, M. H., Chang, Y. C. & Hsiao, M., 1月 2023, 於: Molecules. 28, 1, 364.

研究成果: Review article › 同行評審

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19 引文斯高帕斯（Scopus）

Low Expression of A3C and PLP2 Indicating a Favorable Prognosis in Human Gliomas

Jin, J. S., Tsai, Y. L., Chang, Y. C. & Tsai, W. C., 2023, 於: Cellular and Molecular Biology. 69, 7, p. 71-79 9 p.

研究成果: Article › 同行評審

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2 引文斯高帕斯（Scopus）

Mucin 4 Confers Gemcitabine Resistance and an Unfavorable Prognosis in Patients with Cholangiocarcinoma via AKT Activation

Pan, Y. R., Wu, C. E., Jung, S. M., Huang, S. C., Lin, S. H., Chou, W. C., Chang, Y. C., Chen, M. H., Hung, T. H., Yu, A. L., Huang, W. K. & Yeh, C. N., 2023, 於: International journal of biological sciences. 19, 9, p. 2772-2786 15 p.

研究成果: Article › 同行評審

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4 引文斯高帕斯（Scopus）

Overexpression of synaptic vesicle protein Rab GTPase 3C promotes vesicular exocytosis and drug resistance in colorectal cancer cells

Chang, Y. C., Li, C. H., Chan, M. H., Fang, C. Y., Zhang, Z. X., Chen, C. L. & Hsiao, M., 3月 2023, 於: Molecular Oncology. 17, 3, p. 422-444 23 p.

研究成果: Article › 同行評審

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6 引文斯高帕斯（Scopus）

The activation of EP300 by F11R leads to EMT and acts as a prognostic factor in triple-negative breast cancers

Li, C. H., Fang, C. Y., Chan, M. H., Lu, P. J., Ger, L. P., Chu, J. S., Chang, Y. C., Chen, C. L. & Hsiao, M., 5月 2023, 於: Journal of Pathology: Clinical Research. 9, 3, p. 165-181 17 p.

研究成果: Article › 同行評審

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3 引文斯高帕斯（Scopus）

The cytoplasmic expression of FSTL3 correlates with colorectal cancer progression, metastasis status and prognosis

Li, C. H., Fang, C. Y., Chan, M. H., Chen, C. L., Chang, Y. C. & Hsiao, M., 3月 2023, 於: Journal of Cellular and Molecular Medicine. 27, 5, p. 672-686 15 p.

研究成果: Article › 同行評審

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2 引文斯高帕斯（Scopus）

2022

Aldolase A and Phospholipase D1 Synergistically Resist Alkylating Agents and Radiation in Lung Cancer

Chang, Y. C., Chang, P. M. H., Li, C. H., Chan, M. H., Lee, Y. J., Chen, M. H. & Hsiao, M., 21 1月 2022, 於: Frontiers in Oncology. 11, 811635.

研究成果: Article › 同行評審

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8 引文斯高帕斯（Scopus）

Application of Metabolic Reprogramming to Cancer Imaging and Diagnosis

Yang, Y. F., Li, C. H., Cai, H. Y., Lin, B. S., Kim, C. H. & Chang, Y. C., 12月 2022, 於: International Journal Of Molecular Sciences. 23, 24, 15831.

研究成果: Review article › 同行評審

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1 引文斯高帕斯（Scopus）

Fascin-1: Updated biological functions and therapeutic implications in cancer biology

Li, C. H., Chan, M. H., Liang, S. M., Chang, Y. C. & Hsiao, M., 1月 2022, 於: BBA Advances. 2, 100052.

研究成果: Review article › 同行評審

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4 引文斯高帕斯（Scopus）

FAS receptor regulates NOTCH activity through ERK-JAG1 axis activation and controls oral cancer stemness ability and pulmonary metastasis

Li, L. J., Chang, P. M. H., Li, C. H., Chang, Y. C., Lai, T. C., Su, C. Y., Chen, C. L., Chang, W. M., Hsiao, M. & Feng, S. W., 12月 2022, 於: Cell Death Discovery. 8, 1, 101.

研究成果: Article › 同行評審

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9 引文斯高帕斯（Scopus）

High expression of tight junction protein 1 as a predictive biomarker for bladder cancer grade and staging

Lee, Y. C., Tsai, K. W., Liao, J. B., Kuo, W. T., Chang, Y. C. & Yang, Y. F., 12月 2022, 於: Scientific reports. 12, 1, 1496.

研究成果: Article › 同行評審

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6 引文斯高帕斯（Scopus）

Iron-Based Ceramic Composite Nanomaterials for Magnetic Fluid Hyperthermia and Drug Delivery

Chan, M. H., Li, C. H., Chang, Y. C. & Hsiao, M., 12月 2022, 於: Pharmaceutics. 14, 12, 2584.

研究成果: Review article › 同行評審

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12 引文斯高帕斯（Scopus）

Molecular Research of Glycolysis

Chang, Y. C. & Kim, C. H., 1 5月 2022, 於: International Journal Of Molecular Sciences. 23, 9, 5052.

研究成果: Editorial

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6 引文斯高帕斯（Scopus）

Prostaglandin F2 receptor inhibitor overexpression predicts advanced who grades and adverse prognosis in human glioma tissue

Chen, H. W., Lin, M. C., Wu, P. R., Chang, Y. C., Weng, S. S. & Tsai, W. C., 1 3月 2022, 於: Chinese Journal of Physiology. 65, 2, p. 93-102 10 p.

研究成果: Article › 同行評審

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Regorafenib inhibits epithelial-mesenchymal transition and suppresses cholangiocarcinoma metastasis via YAP1-AREG axis

Chang, Y. C., Li, C. H., Chan, M. H., Chen, M. H., Yeh, C. N. & Hsiao, M., 4月 2022, 於: Cell Death and Disease. 13, 4, 391.

研究成果: Article › 同行評審

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5 引文斯高帕斯（Scopus）

Revisited Metabolic Control and Reprogramming Cancers by Means of the Warburg Effect in Tumor Cells

Fukushi, A., Kim, H. D., Chang, Y. C. & Kim, C. H., 9月 2022, 於: International Journal Of Molecular Sciences. 23, 17, 10037.

研究成果: Review article › 同行評審

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60 引文斯高帕斯（Scopus）

The aberrant cancer metabolic gene carbohydrate sulfotransferase 11 promotes non-small cell lung cancer cell metastasis via dysregulation of ceruloplasmin and intracellular iron balance

Chang, W. M., Li, L. J., Chiu, I. A., Lai, T. C., Chang, Y. C., Tsai, H. F., Yang, C. J., Huang, M. S., Su, C. Y., Lai, T. L., Jan, Y. H. & Hsiao, M., 11月 2022, 於: Translational Oncology. 25, 101508.

研究成果: Article › 同行評審

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6 引文斯高帕斯（Scopus）

The CHST11 gene is linked to lung cancer and pulmonary fibrosis

Li, C. H., Chan, M. H., Chang, Y. C. & Hsiao, M., 12月 2022, 於: Journal of Gene Medicine. 24, 12, e3451.

研究成果: Article › 同行評審

2 引文斯高帕斯（Scopus）

The role of fructose 1,6-bisphosphate-mediated glycolysis/gluconeogenesis genes in cancer prognosis

Li, C. H., Chan, M. H. & Chang, Y. C., 2022, 於: Aging. 14, 7, p. 3233-3258 26 p.

研究成果: Article › 同行評審

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17 引文斯高帕斯（Scopus）

UBE2C triggers HIF-1α-glycolytic flux in head and neck squamous cell carcinoma

Yang, Y. F., Chang, Y. C., Tsai, K. W., Hung, M. H. & Kang, B. H., 7月 2022, 於: Journal of Cellular and Molecular Medicine. 26, 13, p. 3716-3725 10 p.

研究成果: Article › 同行評審

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9 引文斯高帕斯（Scopus）

Ultrasound and Nanomedicine for Cancer-Targeted Drug Delivery: Screening, Cellular Mechanisms and Therapeutic Opportunities

Li, C. H., Chang, Y. C., Hsiao, M. & Chan, M. H., 6月 2022, 於: Pharmaceutics. 14, 6, 1282.

研究成果: Review article › 同行評審

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7 引文斯高帕斯（Scopus）

2021

ALDH2 deficiency induces atrial fibrillation through dysregulated cardiac sodium channel and mitochondrial bioenergetics: A multi-omics analysis

Hu, Y. F., Wu, C. H., Lai, T. C., Chang, Y. C., Hwang, M. J., Chang, T. Y., Weng, C. H., Chang, P. M. H., Chen, C. H., Mochly-Rosen, D., Huang, C. Y. F. & Chen, S. A., 1 5月 2021, 於: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1867, 5, 166088.

研究成果: Article › 同行評審

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8 引文斯高帕斯（Scopus）

An Advanced in Situ Magnetic Resonance Imaging and Ultrasonic Theranostics Nanocomposite Platform: Crossing the Blood-Brain Barrier and Improving the Suppression of Glioblastoma Using Iron-Platinum Nanoparticles in Nanobubbles

Chan, M. H., Chen, W., Li, C. H., Fang, C. Y., Chang, Y. C., Wei, D. H., Liu, R. S. & Hsiao, M., 16 6月 2021, 於: ACS Applied Materials and Interfaces. 13, 23, p. 26759-26769 11 p.

研究成果: Article › 同行評審

49 引文斯高帕斯（Scopus）

An annotation-free whole-slide training approach to pathological classification of lung cancer types using deep learning

Chen, C. L., Chen, C. C., Yu, W. H., Chen, S. H., Chang, Y. C., Hsu, T. I., Hsiao, M., Yeh, C. Y. & Chen, C. Y., 1 12月 2021, 於: Nature Communications. 12, 1, 1193.

研究成果: Article › 同行評審

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115 引文斯高帕斯（Scopus）

Current Development and Application of Anaerobic Glycolytic Enzymes in Urothelial Cancer

Yang, Y.-F., Chuang, H.-W., Kuo, W.-T., Lin, B.-S. & Chang, Y.-C., 9月 2021, 於: International Journal Of Molecular Sciences. 22, 19, p. 1-22 22 p.

研究成果: Article › 同行評審

10 引文斯高帕斯（Scopus）

Direct interaction of β-catenin with nuclear ESM1 supports stemness of metastatic prostate cancer

Pan, K. F., Lee, W. J., Chou, C. C., Yang, Y. C., Chang, Y. C., Chien, M. H., Hsiao, M. & Hua, K. T., 15 2月 2021, 於: EMBO Journal. 40, 4, e105450.

研究成果: Article › 同行評審

26 引文斯高帕斯（Scopus）

Exosomal components and modulators in colorectal cancer: Novel diagnosis and prognosis biomarkers

Chang, Y. C., Chan, M. H., Li, C. H., Fang, C. Y., Hsiao, M. & Chen, C. L., 8月 2021, 於: Biomedicines. 9, 8, 931.

研究成果: Review article › 同行評審

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14 引文斯高帕斯（Scopus）

Galectins in cancer and the microenvironment: Functional roles, therapeutic developments, and perspectives

Li, C. H., Chang, Y. C., Chan, M. H., Yang, Y. F., Liang, S. M. & Hsiao, M., 9月 2021, 於: Biomedicines. 9, 9, 1159.

研究成果: Review article › 同行評審

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22 引文斯高帕斯（Scopus）

Magnetically guided theranostics: montmorillonite-based iron/platinum nanoparticles for enhancing in situ MRI contrast and hepatocellular carcinoma treatment

Chan, M. H., Lu, C. N., Chung, Y. L., Chang, Y. C., Li, C. H., Chen, C. L., Wei, D. H. & Hsiao, M., 12月 2021, 於: Journal of Nanobiotechnology. 19, 1, 308.

研究成果: Article › 同行評審

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19 引文斯高帕斯（Scopus）

Metabolic protein phosphoglycerate kinase 1 confers lung cancer migration by directly binding HIV Tat specific factor 1

Chang, Y. C., Chan, M. H., Li, C. H., Yang, C. J., Tseng, Y. W., Tsai, H. F., Chiou, J. & Hsiao, M., 6月 2021, 於: Cell Death Discovery. 7, 1, 135.

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12 引文斯高帕斯（Scopus）

Novel Monodisperse FePt Nanocomposites for T2-Weighted Magnetic Resonance Imaging: Biomedical Theranostics Applications

Chang, Z.-X., Li, C.-H., Chang, Y.-C., Huang, C.-Y., Chan, M.-H. & Hsiao, M., 11月 2021, 於: Nanoscale Advances. 4, 2, p. 377-386 11 p.

研究成果: Article › 同行評審

9 引文斯高帕斯（Scopus）

Oncomir mir-182-5p enhances radiosensitivity by inhibiting the radiation-induced antioxidant effect through sesn2 in head and neck cancer

Lin, M. Y., Chang, Y. C., Wang, S. Y., Yang, M. H., Chang, C. H., Hsiao, M., Kitsis, R. N. & Lee, Y. J., 11月 2021, 於: Antioxidants. 10, 11, 1808.

研究成果: Article › 同行評審

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14 引文斯高帕斯（Scopus）

Ruxolitinib combined with gemcitabine against cholangiocarcinoma growth via the jak2/stat1/3/aldh1a3 pathway

Chung, S. Y., Hung, Y. P., Pan, Y. R., Chang, Y. C., Wu, C. E., Hsu, D. S. S., Chang, P. M. H., Lu, M. L., Huang, C. Y. F., Su, Y., Hsiao, M., Yeh, C. N. & Chen, M. H., 8月 2021, 於: Biomedicines. 9, 8, 885.

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4 引文斯高帕斯（Scopus）

Stationed or Relocating: The Seesawing EMT/MET Determinants from Embryonic Development to Cancer Metastasis

Li, C.-H., Hsu, T.-I., Chang, Y.-C., Chan, M.-H., Lu, P.-J. & Hsiao, M., 9月 2021, 於: Biomedicines. 9, 9, p. 1-28 28 p.

研究成果: Article › 同行評審

11 引文斯高帕斯（Scopus）

Type V collagen alpha 1 chain promotes the malignancy of glioblastoma through PPRC1-ESM1 axis activation and extracellular matrix remodeling

Tsai, H. F., Chang, Y.-C., Li, C. H., Chan, M. H., Chen, C. L., Tsai, W. C. & Hsiao, M., 10月 2021, (E-pub ahead of print) 於: Cell Death Discovery. 7, 313.

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23 引文斯高帕斯（Scopus）

2020

IMPAD1 functions as mitochondrial electron transport inhibitor that prevents ROS production and promotes lung cancer metastasis through the AMPK-Notch1-HEY1 pathway

Yang, Y. F., Wang, Y. Y., Hsiao, M., Lo, S., Chang, Y. C., Jan, Y. H., Lai, T. C., Lee, Y. C., Hsieh, Y. C. & Yuan, S. S. F., 10 8月 2020, 於: Cancer Letters. 485, p. 27-37 11 p.

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14 引文斯高帕斯（Scopus）

Molecular mechanisms of KDELC2 on glioblastoma tumorigenesis and temozolomide resistance

Tsai, Y. L., Chang, H. H., Chen, Y. C., Chang, Y. C., Chen, Y. & Tsai, W. C., 9月 2020, 於: Biomedicines. 8, 9, 339.

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15 引文斯高帕斯（Scopus）

Nonenzymatic function of Aldolase A downregulates miR-145 to promote the Oct4/DUSP4/TRAF4 axis and the acquisition of lung cancer stemness

Chang, Y. C., Yang, Y. F., Chiou, J., Tsai, H. F., Fang, C. Y., Yang, C. J., Chen, C. L. & Hsiao, M., 1 3月 2020, 於: Cell Death and Disease. 11, 3, 195.

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19 引文斯高帕斯（Scopus）

Omics-based platforms: Current status and potential use for cholangiocarcinoma

Chang, Y. C., Chen, M. H., Yeh, C. N. & Hsiao, M., 10月 2020, 於: Biomolecules. 10, 10, p. 1-25 25 p., 1377.

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6 引文斯高帕斯（Scopus）

Overexpression of PSAT1 promotes metastasis of lung adenocarcinoma by suppressing the IRF1-IFNγ axis

Chan, Y. C., Chang, Y. C., Chuang, H. H., Yang, Y. C., Lin, Y. F., Huang, M. S., Hsiao, M., Yang, C. J. & Hua, K. T., 19 3月 2020, 於: Oncogene. 39, 12, p. 2509-2522 14 p.

研究成果: Article › 同行評審

36 引文斯高帕斯（Scopus）

PRKDC: New biomarker and drug target for checkpoint blockade immunotherapy

Tan, K. T., Yeh, C. N., Chang, Y. C., Cheng, J. H., Fang, W. L., Yeh, Y. C., Wang, Y. C., Hsu, D. S. S., Wu, C. E., Lai, J. I., Chang, P. M. H., Chen, M. H., Lu, M. L., Chen, S. J., Chao, Y., Hsiao, M. & Chen, M. H., 1 4月 2020, 於: Journal for ImmunoTherapy of Cancer. 8, 1, e000485.

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41 引文斯高帕斯（Scopus）

張 御展

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張御展