蔡 金吾

研究成果

每年研究成果 1999 2016 2018 2019 2020 2022

• 38 Article
• 3 Review article
• 2 Conference article
• 1 Paper

每年研究成果

每年研究成果

搜尋結果

• 2022

  Novel lissencephaly-associated DCX variants in the C-terminal DCX domain affect microtubule binding and dynamics

  Lin, J. R., Cheng, J. F., Liu, Y. T., Hsu, T. R., Lin, K. M., Chen, C., Lin, C. L., Tsai, M. H. & Tsai, J. W., 2022, (Accepted/In press) 於: Epilepsia.

  研究成果: Article › 同行評審

  • Lissencephaly 100%
  • Microtubules 65%
  • Classical Lissencephalies and Subcortical Band Heterotopias 31%
  • Band Heterotopia of Brain 22%
  • Whole Exome Sequencing 11%

• Thymic macrophages consist of two populations with distinct localization and origin

  Zhou, T. A., Hsu, H. P., Tu, Y. H., Cheng, H. K., Lin, C. Y., Chen, N-J., Tsai, J-W., Robey, E. A., Huang, H. C., Hsu, C-L. & Dzhagalov, I. L., 30 11月 2022, 於: eLife. 11

  研究成果: Article › 同行評審

  開啟存取

  • RNA Sequencing 100%
  • Apoptotic 69%
  • Macrophages 42%
  • Red 41%
  • Population 23%
• 2021

  An emerging role of prrt2 in regulating growth cone morphology

  Savino, E., Guarnieri, F. C., Tsai, J. W., Corradi, A., Benfenati, F. & Valtorta, F., 10月 2021, 於: Cells. 10, 10, 2666.

  研究成果: Article › 同行評審

  開啟存取

  • Growth Cones 100%
  • Actin Cytoskeleton 25%
  • Episodic Ataxia 22%
  • Familial paroxysmal dystonia 21%
  • Neurons 16%

• Clinical and functional characterization of a novel STUB1 frameshift mutation in autosomal dominant spinocerebellar ataxia type 48 (SCA48)

  Chen, H. Y., Hsu, C. L., Lin, H. Y., Lin, Y. F., Tsai, S. F., Ho, Y. J., Li, Y. R., Tsai, J. W., Teng, S. C. & Lin, C. H., 12月 2021, 於: Journal of Biomedical Science. 28, 1, 65.

  研究成果: Article › 同行評審

  開啟存取

  • HSC70 Heat-Shock Proteins 100%
  • Spinocerebellar Ataxias 83%
  • Frameshift Mutation 76%
  • Mutation 52%
  • Ataxia 39%
  6 引文 斯高帕斯（Scopus）
• 2020

  Cellular secretion and cytotoxicity of transthyretin mutant proteins underlie late-onset amyloidosis and neurodegeneration

  Ibrahim, R. B., Yeh, S. Y., Lin, K. P., Ricardo, F., Yu, T. Y., Chan, C. C., Tsai, J. W. & Liu, Y. T., 1 4月 2020, 於: Cellular and Molecular Life Sciences. 77, 7, p. 1421-1434 14 p.

  研究成果: Article › 同行評審

  • Prealbumin 100%
  • Amyloidosis 90%
  • Mutant Proteins 86%
  • Quality Control 23%
  • Endoplasmic Reticulum 23%
  6 引文 斯高帕斯（Scopus）

• Efficient in Utero Gene Transfer to the Mammalian Inner Ears by the Synthetic Adeno-Associated Viral Vector Anc80L65

  Hu, C. J., Lu, Y. C., Tsai, Y. H., Cheng, H. Y., Takeda, H., Huang, C. Y., Xiao, R., Hsu, C. J., Tsai, J. W., Vandenberghe, L. H., Wu, C. C. & Cheng, Y. F., 11 9月 2020, 於: Molecular Therapy - Methods and Clinical Development. 18, p. 493-500 8 p.

  研究成果: Article › 同行評審

  開啟存取

  • Vestibular Hair Cells 100%
  • Auditory Hair Cells 91%
  • Spiral Ganglion 87%
  • Inner Ear 68%
  • Hearing Loss 60%
  10 引文 斯高帕斯（Scopus）

• Impairment in dynein-mediated nuclear translocation by BICD2 C-terminal truncation leads to neuronal migration defect and human brain malformation

  Tsai, M. H., Cheng, H. Y., Nian, F. S., Liu, C., Chao, N. H., Chiang, K. L., Chen, S. F. & Tsai, J. W., 14 7月 2020, 於: Acta neuropathologica communications. 8, 1, 106.

  研究成果: Article › 同行評審

  開啟存取

  • Dyneins 100%
  • Nuclear Envelope 86%
  • Lissencephaly 85%
  • Centrosome 71%
  • Spinal Muscular Atrophy 49%
  10 引文 斯高帕斯（Scopus）

• Muscle atrophy-related myotube-derived exosomal microRNA in neuronal dysfunction: Targeting both coding and long noncoding RNAs

  Yang, C. P., Yang, W. S., Wong, Y. H., Wang, K. H., Teng, Y. C., Chang, M. H., Liao, K. H., Nian, F. S., Chao, C. C., Tsai, J. W., Hwang, W. L., Lin, M. W., Tzeng, T. Y., Wang, P. N., Campbell, M., Chen, L. K., Tsai, T. F., Chang, P. C. & Kung, H. J., 1 5月 2020, 於: Aging Cell. 19, 5, e13107.

  研究成果: Article › 同行評審

  開啟存取

  • Muscular Atrophy 100%
  • Skeletal Muscle Fibers 97%
  • Long Noncoding RNA 93%
  • MicroRNAs 73%
  • Exosomes 68%
  18 引文 斯高帕斯（Scopus）

• Pathogenic Variants in CEP85L Cause Sporadic and Familial Posterior Predominant Lissencephaly

  University of Washington Center for Mendelian Genomics, 22 4月 2020, 於: Neuron. 106, 2, p. 237-245.e8

  研究成果: Article › 同行評審

  開啟存取

  • Lissencephaly 100%
  • Centrosome 33%
  • Organelles 12%
  • Brain 6%
  • Genes 5%
  10 引文 斯高帕斯（Scopus）

• WNT3A promotes neuronal regeneration upon traumatic brain injury

  Chang, C. Y., Liang, M. Z., Wu, C. C., Huang, P. Y., Chen, H. I., Yet, S. F., Tsai, J. W., Kao, C. F. & Chen, L., 2 2月 2020, 於: International Journal Of Molecular Sciences. 21, 4, 1463.

  研究成果: Article › 同行評審

  開啟存取

  • brain damage 100%
  • Intranasal 98%
  • regeneration 68%
  • Traumatic Brain Injury 60%
  • Neurons 55%
  11 引文 斯高帕斯（Scopus）
• 2019

  Atoh1 Controls Primary Cilia Formation to Allow for SHH-Triggered Granule Neuron Progenitor Proliferation

  Chang, C. H., Zanini, M., Shirvani, H., Cheng, J. S., Yu, H., Feng, C. H., Mercier, A. L., Hung, S. Y., Forget, A., Wang, C. H., Cigna, S. M., Lu, I. L., Chen, W. Y., Leboucher, S., Wang, W. J., Ruat, M., Spassky, N., Tsai, J. W. & Ayrault, O., 28 1月 2019, 於: Developmental Cell. 48, 2, p. 184-199.e5

  研究成果: Article › 同行評審

  開啟存取

  • Proliferative 100%
  • Hedgehog Proteins 94%
  • Cilia 87%
  • Neurons 46%
  • Basal Bodies 13%
  38 引文 斯高帕斯（Scopus）

• Constitutive inactivation of the prrt2 gene alters short-term synaptic plasticity and promotes network hyperexcitability in hippocampal neurons

  Valente, P., Romei, A., Fadda, M., Sterlini, B., Lonardoni, D., Forte, N., Fruscione, F., Castroflorio, E., Michetti, C., Giansante, G., Valtorta, F., Tsai, J. W., Zara, F., Nieus, T., Corradi, A., Fassio, A., Baldelli, P. & Benfenati, F., 5月 2019, 於: Cerebral Cortex. 29, 5, p. 2010-2033 24 p., bhy079.

  研究成果: Article › 同行評審

  • human PRRT2 protein 100%
  • Gene Silencing 54%
  • Neuronal Plasticity 48%
  • Neurons 31%
  • Synaptic Transmission 11%
  22 引文 斯高帕斯（Scopus）

• Gli2 Rescues Delays in Brain Development Induced by Kif3a Dysfunction

  Chen, J. L., Chang, C. H. & Tsai, J. W., 1 2月 2019, 於: Cerebral Cortex. 29, 2, p. 751-764 14 p.

  研究成果: Article › 同行評審

  • Neural Stem Cells 100%
  • Ciliopathies 66%
  • Cyclin D1 48%
  • Brain 43%
  • Cell Cycle 35%
  14 引文 斯高帕斯（Scopus）

• Multiple Functions of KBP in Neural Development Underlie Brain Anomalies in Goldberg-Shprintzen Syndrome

  Chang, H. Y., Cheng, H. Y., Tsao, A. N., Liu, C. & Tsai, J. W., 1 11月 2019, 於: Frontiers in Molecular Neuroscience. 12, 265.

  研究成果: Article › 同行評審

  開啟存取

  • Goldberg-Shprintzen megacolon syndrome 100%
  • Kinesin 39%
  • Electroporation 36%
  • Polymicrogyria 23%
  • Brain 22%
  4 引文 斯高帕斯（Scopus）

• PRRT2 missense mutations cluster near C-terminus and frequently lead to protein mislocalization

  Tsai, M. H., Nian, F. S., Hsu, M. H., Liu, W. S., Liu, Y. T., Liu, C., Lin, P. H., Hwang, D. Y., Chuang, Y. C. & Tsai, J. W., 5月 2019, 於: Epilepsia. 60, 5, p. 807-817 11 p.

  研究成果: Article › 同行評審

  • Familial paroxysmal dystonia 100%
  • Missense Mutation 77%
  • Cell Membrane 54%
  • Mutant Proteins 32%
  • Nervous System Diseases 28%
  9 引文 斯高帕斯（Scopus）

• Rab18 Collaborates with Rab7 to Modulate Lysosomal and Autophagy Activities in the Nervous System: an Overlapping Mechanism for Warburg Micro Syndrome and Charcot-Marie-Tooth Neuropathy Type 2B

  Nian, F. S., Li, L. L., Cheng, C. Y., Wu, P. C., Lin, Y. T., Tang, C. Y., Ren, B. S., Tai, C. Y., Fann, M. J., Kao, L. S., Hong, C. J. & Tsai, J. W., 15 9月 2019, 於: Molecular Neurobiology. 56, 9, p. 6095-6105 11 p.

  研究成果: Article › 同行評審

  • Type 2B Charcot-Marie-Tooth disease 100%
  • Warburg Sjo Fledelius syndrome 96%
  • Autophagy 47%
  • Nervous System 40%
  • Neurons 30%
  14 引文 斯高帕斯（Scopus）
• 2018

  A rare human CEP290 variant disrupts the molecular integrity of the primary cilium and impairs Sonic Hedgehog machinery

  Kilander, M. B. C., Wang, C. H., Chang, C. H., Nestor, J. E., Herold, K., Tsai, J. W., Nestor, M. W. & Lin, Y. C., 1 12月 2018, 於: Scientific reports. 8, 1, 17335.

  研究成果: Article › 同行評審

  開啟存取

  • Human Cep290 protein 100%
  • Hedgehog Proteins 51%
  • Cilia 47%
  • Ciliopathies 17%
  • Proteins 15%
  9 引文 斯高帕斯（Scopus）

• Contactin-1/F3 regulates neuronal migration and morphogenesis through modulating rhoa activity

  Chen, Y. A., Lu, I. L. & Tsai, J. W., 20 11月 2018, 於: Frontiers in Molecular Neuroscience. 11, 422.

  研究成果: Article › 同行評審

  開啟存取

  • Contactin 1 100%
  • Morphogenesis 53%
  • Cerebral Cortex 14%
  • Neurons 14%
  • Axon Guidance 9%
  19 引文 斯高帕斯（Scopus）

• Gli2 modulates cell cycle re-entry through autophagy-mediated regulation of the length of primary cilia

  Hsiao, C. J., Chang, C. H., Ibrahim, R. B., Lin, I. H., Wang, C. H., Wang, W. J. & Tsai, J. W., 2018, 於: Journal of cell science. 131, 24, jcs221218.

  研究成果: Article › 同行評審

  開啟存取

  • Cilia 100%
  • Autophagy 82%
  • Cell Cycle 67%
  • Fibroblasts 63%
  • Transcription Factors 32%
  16 引文 斯高帕斯（Scopus）

• Identification of genes associated with cortical malformation using a transposon-mediated somatic mutagenesis screen in mice

  Lu, I. L., Chen, C., Tung, C. Y., Chen, H. H., Pan, J. P., Chang, C. H., Cheng, J. S., Chen, Y. A., Wang, C. H., Huang, C. W., Kang, Y. N., Chang, H. Y., Li, L. L., Chang, K. P., Shih, Y. H., Lin, C. H., Kwan, S. Y. & Tsai, J. W., 1 12月 2018, 於: Nature Communications. 9, 1, 2498.

  研究成果: Article › 同行評審

  開啟存取

  • mutagenesis 100%
  • genes 79%
  • Malformations of Cortical Development 78%
  • mice 70%
  • Mutagenesis 66%
  16 引文 斯高帕斯（Scopus）

• Lis1 dysfunction leads to traction force reduction and cytoskeletal disorganization during cell migration

  Jheng, G. W., Hur, S. S., Chang, C. M., Wu, C. C., Cheng, J. S., Lee, H. H., Chung, B. C., Wang, Y. K., Lin, K. H., del Álamo, J. C., Chien, S. & Tsai, J. W., 11 3月 2018, 於: Biochemical and Biophysical Research Communications. 497, 3, p. 869-875 7 p.

  研究成果: Article › 同行評審

  • Traction 100%
  • Cell Movement 75%
  • Force 62%
  • Reduction 41%
  • Focal Adhesions 31%
  17 引文 斯高帕斯（Scopus）
• 2017

  Ascl1 promotes tangential migration and confines migratory routes by induction of Ephb2 in the telencephalon

  Liu, Y. H., Tsai, J. W., Chen, J. L., Yang, W. S., Chang, P. C., Cheng, P. L., Turner, D. L., Yanagawa, Y., Wang, T. W. & Yu, J. Y., 9 3月 2017, 於: Scientific reports. 7, 42895.

  研究成果: Article › 同行評審

  開啟存取

  • EphA1 Receptor 100%
  • Telencephalon 72%
  • Lateral Ventricles 38%
  • Homeobox Genes 27%
  • Interneurons 24%
  6 引文 斯高帕斯（Scopus）

• Cdk12 regulates neurogenesis and late-arising neuronal migration in the developing cerebral cortex

  Chen, H. R., Juan, H. C., Wong, Y. H., Tsai, J. W. & Fann, M. J., 1 3月 2017, 於: Cerebral Cortex. 27, 3, p. 2289-2302 14 p.

  研究成果: Article › 同行評審

  • Neurogenesis 100%
  • Cerebral Cortex 87%
  • Neurons 58%
  • DNA Damage 54%
  • Stem Cells 34%
  12 引文 斯高帕斯（Scopus）

• Inhibitory effects of curcumin and cyclocurcumin in 1-methyl-4-phenylpyridinium (MPP+) induced neurotoxicity in differentiated PC12 cells

  Chakraborty, S., Karmenyan, A., Tsai, J. W. & Chiou, A., 1 12月 2017, 於: Scientific reports. 7, 1, 16977.

  研究成果: Article › 同行評審

  開啟存取

  • 1-Methyl-4-phenylpyridinium 100%
  • PC12 Cells 78%
  • Curcumin 78%
  • NAD 70%
  • Diarylheptanoids 53%
  15 引文 斯高帕斯（Scopus）
• 2016

  A novel DCX missense mutation in a family with X-linked lissencephaly and subcortical band heterotopia syndrome inherited from a low-level somatic mosaic mother: Genetic and functional studies

  Tsai, M. H., Kuo, P. W., Myers, C. T., Li, S. W., Lin, W. C., Fu, T. Y., Chang, H. Y., Mefford, H. C., Chang, Y. C. & Tsai, J. W., 1 9月 2016, 於: European Journal of Paediatric Neurology. 20, 5, p. 788-794 7 p.

  研究成果: Article › 同行評審

  • X-Linked Subcortical Band Heterotopia 100%
  • Classical Lissencephalies and Subcortical Band Heterotopias 71%
  • Missense Mutation 45%
  • Molecular Probe Techniques 44%
  • Microtubules 31%
  7 引文 斯高帕斯（Scopus）

• Experience-dependent plasticity of dendritic spines of layer 2/3 pyramidal neurons in the mouse cortex

  Ma, L., Qiao, Q., Tsai, J. W., Yang, G., Li, W. & Gan, W. B., 1 3月 2016, 於: Developmental Neurobiology. 76, 3, p. 277-286 10 p.

  研究成果: Article › 同行評審

  • Dendritic Spines 100%
  • Pyramidal Cells 86%
  • Spine 39%
  • Sensory Deprivation 31%
  • Motor Cortex 20%
  50 引文 斯高帕斯（Scopus）

• Long-term stability of axonal boutons in the mouse barrel cortex

  Qiao, Q., Ma, L., Li, W., Tsai, J. W., Yang, G. & Gan, W. B., 1 3月 2016, 於: Developmental Neurobiology. 76, 3, p. 252-261 10 p.

  研究成果: Article › 同行評審

  • Dendritic Spines 100%
  • Somatosensory Cortex 47%
  • Presynaptic Terminals 45%
  • Photons 43%
  • Plastics 39%
  30 引文 斯高帕斯（Scopus）

• PRRT2 mutations lead to neuronal dysfunction and neurodevelopmental defects

  Liu, Y. T., Nian, F. S., Chou, W. J., Tai, C. Y., Kwan, S. Y., Chen, C., Kuo, P. W., Lin, P. H., Chen, C. Y., Huang, C. W., Lee, Y. C., Soong, B. W. & Tsai, J. W., 2016, 於: Oncotarget. 7, 26, p. 39184-39196 13 p.

  研究成果: Article › 同行評審

  開啟存取

  • human PRRT2 protein 100%
  • Familial paroxysmal dystonia 42%
  • Synaptic Membranes 33%
  • Mutation 28%
  • Neurons 15%
  41 引文 斯高帕斯（Scopus）

• Quantification of the Metabolic State in Cell-Model of Parkinsona (tm) s Disease by Fluorescence Lifetime Imaging Microscopy

  Chakraborty, S., Nian, F. S., Tsai, J. W., Karmenyan, A. & Chiou, A., 13 1月 2016, 於: Scientific reports. 6, 19145.

  研究成果: Article › 同行評審

  開啟存取

  • Flavin-Adenine Dinucleotide 100%
  • Optical Imaging 97%
  • NAD 91%
  • Microscopy 74%
  • Parkinson Disease 37%
  42 引文 斯高帕斯（Scopus）
• 2015

  ENU mutagenesis identifies mice modeling Warburg Micro Syndrome with sensory axon degeneration caused by a deletion in Rab18

  Cheng, C. Y., Wu, J. C., Tsai, J. W., Nian, F. S., Wu, P. C., Kao, L. S., Fann, M. J., Tsai, S. J., Liou, Y. J., Tai, C. Y. & Hong, C. J., 1 5月 2015, 於: Experimental Neurology. 267, p. 143-151 9 p.

  研究成果: Article › 同行評審

  • Warburg Sjo Fledelius syndrome 100%
  • Mutagenesis 51%
  • Axons 45%
  • Optic Nerve 15%
  • Gait 14%
  5 引文 斯高帕斯（Scopus）
• 2011

  A new subtype of progenitor cell in the mouse embryonic neocortex

  Wang, X., Tsai, J. W., Lamonica, B. & Kriegstein, A. R., 5月 2011, 於: Nature Neuroscience. 14, 5, p. 555-562 8 p.

  研究成果: Article › 同行評審

  • Neocortex 100%
  • Neuroglia 78%
  • Stem Cells 65%
  • Lateral Ventricles 32%
  • Brain 21%
  357 引文 斯高帕斯（Scopus）

• Live microscopy of neural stem cell migration in brain slices.

  Tsai, J. W. & Vallee, R. B., 2011, 於: Methods in molecular biology (Clifton, N.J.). 750, p. 131-142 12 p.

  研究成果: Article › 同行評審

  • Neural Stem Cells 100%
  • Microscopy 74%
  • Cell Movement 73%
  • Brain Diseases 56%
  • Lissencephaly 44%
  4 引文 斯高帕斯（Scopus）
• 2010

  Kinesin 3 and cytoplasmic dynein mediate interkinetic nuclear migration in neural stem cells

  Tsai, J. W., Lian, W. N., Kemal, S., Kriegstein, A. R. & Vallee, R. B., 12月 2010, 於: Nature Neuroscience. 13, 12, p. 1463-1472 10 p.

  研究成果: Article › 同行評審

  • Cytoplasmic Dyneins 100%
  • Kinesin 84%
  • Neural Stem Cells 73%
  • Microtubules 64%
  • RNA Interference 63%
  175 引文 斯高帕斯（Scopus）
• 2009

  Asymmetric centrosome inheritance maintains neural progenitors in the neocortex

  Wang, X., Tsai, J. W., Imai, J. H., Lian, W. N., Vallee, R. B. & Shi, S. H., 15 10月 2009, 於: Nature. 461, 7266, p. 947-955 9 p.

  研究成果: Article › 同行評審

  • Centrosome 100%
  • Neocortex 89%
  • Centrioles 80%
  • Neuroglia 60%
  • Neurogenesis 12%
  346 引文 斯高帕斯（Scopus）
• 2007

  Dual subcellular roles for LIS1 and dynein in radial neuronal migration in live brain tissue

  Tsai, J. W., Bremner, K. H. & Vallee, R. B., 8月 2007, 於: Nature Neuroscience. 10, 8, p. 970-979 10 p.

  研究成果: Article › 同行評審

  • Dyneins 100%
  • Myosin Type II 78%
  • Microtubules 74%
  • Centrosome 47%
  • Brain 37%
  344 引文 斯高帕斯（Scopus）
• 2006

  Stepped changes of monovalent ligand-binding force during ligand-induced clustering of integrin α_IIBβ₃

  Hsieh, C. F., Chang, B. J., Pai, C. H., Chen, H. Y., Tsaia, J. W., Yi, Y. H., Chiang, Y. T., Wang, D. W., Chi, S., Hsu, L. & Lin, C. H., 1 9月 2006, 於: Journal of Biological Chemistry. 281, 35, p. 25466-25474 9 p.

  研究成果: Article › 同行評審

  開啟存取

  • Integrins 100%
  • Cluster Analysis 94%
  • Ligands 74%
  • Force 71%
  • rhodostomin 71%
  6 引文 斯高帕斯（Scopus）
• 2005

  LIS1 RNA interference blocks neural stem cell division, morphogenesis, and motility at multiple stages

  Tsai, J. W., Chen, Y., Kriegstein, A. R. & Vallee, R. B., 12 9月 2005, 於: Journal of Cell Biology. 170, 6, p. 935-945 11 p.

  研究成果: Article › 同行評審

  開啟存取

  • Neural Stem Cells 100%
  • Morphogenesis 89%
  • RNA Interference 85%
  • Cell Division 84%
  • Cell Movement 73%
  329 引文 斯高帕斯（Scopus）
• 1999

  Targeting of aminopeptidase N to bile canaliculi correlates with secretory activities of the developing canalicular domain

  Lian, W. N., Tsai, J. W., Yu, P. M., Wu, T. W., Yang, S. C., Chau, Y. P. & Lin, C. H., 1999, 於: Hepatology. 30, 3, p. 748-760 13 p.

  研究成果: Article › 同行評審

  • Bile Canaliculi 100%
  • CD13 Antigens 95%
  • Hepatocellular Carcinoma 20%
  • Membrane Proteins 13%
  • diacetylfluorescein 13%
  22 引文 斯高帕斯（Scopus）