Chin-Yuan Chang

2022

Biomimetic Total Synthesis of the Spiroindimicin Family of Natural Products

Zheng, X., Li, Y., Guan, M., Wang, L., Wei, S., Li, Y. C., Chang, C. Y. & Xu, Z., 2022, (Accepted/In press) 於: Angewandte Chemie - International Edition.

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Characterization and Structural Determination of CmnG-A, the Adenylation Domain That Activates the Nonproteinogenic Amino Acid Capreomycidine in Capreomycin Biosynthesis

Chen, I. H., Cheng, T., Wang, Y. L., Huang, S. J., Hsiao, Y. H., Lai, Y. T., Toh, S. I., Chu, J., Rudolf, J. D. & Chang, C. Y., 16 12月 2022, 於: ChemBioChem. 23, 24, e202200563.

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Crystal structure of the α-ketoglutarate-dependent non-heme iron oxygenase CmnC in capreomycin biosynthesis and its engineering to catalyze hydroxylation of the substrate enantiomer

Hsiao, Y. H., Huang, S. J., Lin, E. C., Hsiao, P. Y., Toh, S. I., Chen, I. H., Xu, Z., Lin, Y. P., Liu, H. J. & Chang, C. Y., 13 9月 2022, 於: Frontiers in Chemistry. 10, 1001311.

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1 引文斯高帕斯（Scopus）

Dual-Mechanism Confers Self-Resistance to the Antituberculosis Antibiotic Capreomycin

Pan, Y. C., Wang, Y. L., Toh, S. I., Hsu, N. S., Lin, K. H., Xu, Z., Huang, S. C., Wu, T. K., Li, T. L. & Chang, C. Y., 21 1月 2022, 於: ACS Chemical Biology. 17, 1, p. 138-146 9 p.

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2 引文斯高帕斯（Scopus）

Electroluminescence and photocatalytic hydrogen evolution of S,N co-doped graphene oxide quantum dots

Cheng, T. Y., Chou, F. P., Huang, S. C., Chang, C. Y. & Wu, T. K., 21 2月 2022, 於: Journal of Materials Chemistry A. 10, 7, p. 3650-3658 9 p.

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9 引文斯高帕斯（Scopus）

Engineering a High-Affinity Anti-Methoxy Poly(ethylene glycol) (mPEG) Antibody for Sensitive Immunosensing of mPEGylated Therapeutics and mPEG Molecules

Hsiao, C. Y., Meng, J. L., Hong, J. Z., Ly, X. H., Lin, M. H., Chang, C. Y., Nguyen, M. T. T., Cheng, T. L., Lin, W. W., Burnouf, P. A., Al-Qaisi, T. S., Liu, E. S. & Su, Y-C., 16 11月 2022, 於: Bioconjugate Chemistry. 33, 11, p. 2180-2188 9 p.

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Structural and Mechanistic Bases for StnK3 and Its Mutant-Mediated Lewis-Acid-Dependent Epimerization and Retro-Aldol Reactions

Chen, M. H., Li, Y. S., Hsu, N. S., Lin, K. H., Wang, Y. L., Wang, Z. C., Chang, C. F., Lin, J. P., Chang, C. Y. & Li, T. L., 4 2月 2022, 於: ACS Catalysis. 12, 3, p. 1945-1956 12 p.

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Structural determination of an antibody that specifically recognizes polyethylene glycol with a terminal methoxy group

Nguyen, M. T. T., Shih, Y. C., Lin, M. H., Roffler, S. R., Hsiao, C. Y., Cheng, T. L., Lin, W. W., Lin, E. C., Jong, Y. J., Chang, C. Y. & Su, Y. C., 12月 2022, 於: Communications Chemistry. 5, 1, 88.

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3 引文斯高帕斯（Scopus）

Structure-guided product determination of the bacterial type II diterpene synthase Tpn2

Stowell, E. A., Ehrenberger, M. A., Lin, Y. L., Chang, C. Y. & Rudolf, J. D., 12月 2022, 於: Communications Chemistry. 5, 1, 146.

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The Structure-Function Relationship of Human Bleomycin Hydrolase: Mutation of a Cysteine Protease into a Serine Protease

Zheng, Y. Z., Cui, J., Wang, Y. L., Huang, S. J., Lin, E. C., Huang, S. C., Rudolf, J. D., Yan, X. & Chang, C. Y., 20 6月 2022, 於: ChemBioChem. 23, 12, e202200186.

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1 引文斯高帕斯（Scopus）

2021

Characterization of Enzymes Catalyzing the Formation of the Nonproteinogenic Amino Acid L-Dap in Capreomycin Biosynthesis

Hsu, S-H., Zhang, S., Huang, S. C., Wu, T-K., Xu, Z. & Chang, C-Y., 12 1月 2021, 於: Biochemistry. 60, 1, p. 77-84 8 p.

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7 引文斯高帕斯（Scopus）

Efficient and Reversible Catalysis of Formic Acid-Carbon Dioxide Cycle Using Carbamate-Substituted Ruthenium-Dithiolate Complexes

Tsai, H. M., Lien, W. H., Liao, C. H., Chen, Y. T., Huang, S. C., Chou, F. P., Chang, C-Y., Yu, J-S. K., Kao, Y-T. & Wu, T-K., 7 10月 2021, 於: ChemCatChem. 13, 19, p. 4092-4098 7 p.

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3 引文斯高帕斯（Scopus）

2020

Characterization of TnmH as an O-Methyltransferase Revealing Insights into Tiancimycin Biosynthesis and Enabling a Biocatalytic Strategy To Prepare Antibody-Tiancimycin Conjugates

Adhikari, A., Teijaro, C. N., Yan, X., Chang, C. Y., Gui, C., Liu, Y. C., Crnovcic, I., Yang, D., Annaval, T., Rader, C. & Shen, B., 13 8月 2020, 於: Journal of Medicinal Chemistry. 63, 15, p. 8432-8441 10 p.

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13 引文斯高帕斯（Scopus）

Pregnenolonyl-α-glucoside exhibits marked anti-cancer and CYP17A1 enzymatic inhibitory activities

Chou, F. P., Hsu, W. C., Huang, S. C., Chang, C. Y., Chiou, Y. S., Tsai, C. T., Lyu, J. W., Chen, W. T. & Wu, T. K., 7 2月 2020, 於: Chemical Communications. 56, 11, p. 1733-1736 4 p.

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2019

Genome mining and biosynthesis of kitacinnamycins as a STING activator

Shi, J., Liu, C. L., Zhang, B., Guo, W. J., Zhu, J., Chang, C-Y., Zhao, E. J., Jiao, R. H., Tan, R. X. & Ge, H. M., 1 1月 2019, 於: Chemical Science. 10, 18, p. 4839-4846 8 p.

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25 引文斯高帕斯（Scopus）

Multiple Pleomorphic Tetramers of Thermostable Direct Hemolysin from Grimontia hollisae in Exerting Hemolysis and Membrane Binding

Wang, Y. K., Huang, S. C., Chang, C-Y., Huang, W. T., Liao, M. J., Yip, B. S., Chou, F. P., Li, T. T. H. & Wu, T-K., 8 7月 2019, 於: Scientific reports. 9, 1, 9833.

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2018

Biochemical and Structural Characterization of TtnD, a Prenylated FMN-Dependent Decarboxylase from the Tautomycetin Biosynthetic Pathway

Annaval, T., Han, L., Rudolf, J. D., Xie, G., Yang, D., Chang, C-Y., Ma, M., Crnovcic, I., Miller, M. D., Soman, J., Xu, W., Phillips, G. N. & Shen, B., 21 9月 2018, 於: ACS Chemical Biology. 13, 9, p. 2728-2738 11 p.

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19 引文斯高帕斯（Scopus）

Comparative Studies of the Biosynthetic Gene Clusters for Anthraquinone-Fused Enediynes Shedding Light into the Tailoring Steps of Tiancimycin Biosynthesis

Yan, X., Chen, J. J., Adhikari, A., Teijaro, C. N., Ge, H., Crnovcic, I., Chang, C-Y., Annaval, T., Yang, D., Rader, C. & Shen, B., 21 9月 2018, 於: Organic Letters. 20, 18, p. 5918-5921 4 p.

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26 引文斯高帕斯（Scopus）

Discovery of Alternative Producers of the Enediyne Antitumor Antibiotic C-1027 with High Titers

Yan, X., Hindra, Ge, H., Yang, D., Huang, T., Crnovcic, I., Chang, C-Y., Fang, S. M., Annaval, T., Zhu, X., Huang, Y., Zhao, L. X., Jiang, Y., Duan, Y. & Shen, B., 23 3月 2018, 於: Journal of Natural Products. 81, 3, p. 594-599 6 p.

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11 引文斯高帕斯（Scopus）

Natural separation of the acyl-CoA ligase reaction results in a non-adenylating enzyme article

Wang, N., Rudolf, J. D., Dong, L. B., Osipiuk, J., Hatzos-Skintges, C., Endres, M., Chang, C-Y., Babnigg, G., Joachimiak, A., Phillips, G. N. & Shen, B., 1 7月 2018, 於: Nature Chemical Biology. 14, 7, p. 730-737 8 p.

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12 引文斯高帕斯（Scopus）

PokMT1 from the Polyketomycin Biosynthetic Machinery of Streptomyces diastatochromogenes Tü6028 Belongs to the Emerging Family of C-Methyltransferases That Act on CoA-Activated Aromatic Substrates

Guo, X., Crnovcic, I., Chang, C-Y., Luo, J., Lohman, J. R., Papinski, M., Bechthold, A., Horsman, G. P. & Shen, B., 13 2月 2018, 於: Biochemistry. 57, 6, p. 1003-1011 9 p.

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5 引文斯高帕斯（Scopus）

Resistance to Enediyne Antitumor Antibiotics by Sequestration

Chang, C-Y., Yan, X., Crnovcic, I., Annaval, T., Chang, C., Nocek, B., Rudolf, J. D., Yang, D., Hindra, Babnigg, G., Joachimiak, A., Phillips, G. N. & Shen, B., 20 9月 2018, 於: Cell Chemical Biology. 25, 9, p. 1075-1085.e4

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18 引文斯高帕斯（Scopus）

Structural Insights into the Free-Standing Condensation Enzyme SgcC5 Catalyzing Ester-Bond Formation in the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027

Chang, C-Y., Lohman, J. R., Huang, T., Michalska, K., Bigelow, L., Rudolf, J. D., Jedrzejczak, R., Yan, X., Ma, M., Babnigg, G., Joachimiak, A., Phillips, G. N. & Shen, B., 12 6月 2018, 於: Biochemistry. 57, 23, p. 3278-3288 11 p.

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8 引文斯高帕斯（Scopus）

The Mesomeric Effect of Thiazolium on non-Kekulé Diradicals in Pichia stipitis Transketolase

Hsu, N. S., Wang, Y. L., Lin, K. H., Chang, C. F., Lyu, S. Y., Hsu, L. J., Liu, Y. C., Chang, C-Y., Wu, C. J. & Li, T. L., 12 2月 2018, 於: Angewandte Chemie - International Edition. 57, 7, p. 1802-1807 6 p.

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3 引文斯高帕斯（Scopus）

2017

Crystal Structure of Thioesterase SgcE10 Supporting Common Polyene Intermediates in 9- and 10-Membered Enediyne Core Biosynthesis

Annaval, T., Rudolf, J. D., Chang, C-Y., Lohman, J. R., Kim, Y., Bigelow, L., Jedrzejczak, R., Babnigg, G., Joachimiak, A., Phillips, G. N. & Shen, B., 1 1月 2017, 於: ACS Omega. 2, 8, p. 5159-5169 11 p.

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8 引文斯高帕斯（Scopus）

Genome Mining of Micromonospora yangpuensis DSM 45577 as a Producer of an Anthraquinone-Fused Enediyne

Yan, X., Chen, J. J., Adhikari, A., Yang, D., Crnovcic, I., Wang, N., Chang, C-Y., Rader, C. & Shen, B., 17 11月 2017, 於: Organic Letters. 19, 22, p. 6192-6195 4 p.

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44 引文斯高帕斯（Scopus）

2016

Characterization of the Ketosynthase and Acyl Carrier Protein Domains at the LnmI Nonribosomal Peptide Synthetase-Polyketide Synthase Interface for Leinamycin Biosynthesis

Huang, Y., Tang, G. L., Pan, G., Chang, C-Y. & Shen, B., 2 9月 2016, 於: Organic Letters. 18, 17, p. 4288-4291 4 p.

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11 引文斯高帕斯（Scopus）

Crystal structure of SgcJ, an NTF2-like superfamily protein involved in biosynthesis of the nine-membered enediyne antitumor antibiotic C-1027

Huang, T., Chang, C-Y., Lohman, J. R., Rudolf, J. D., Kim, Y., Chang, C., Yang, D., Ma, M., Yan, X., Crnovcic, I., Bigelow, L., Clancy, S., Bingman, C. A., Yennamalli, R. M., Babnigg, G., Joachimiak, A., Phillips, G. N. & Shen, B., 1 10月 2016, 於: Journal of Antibiotics. 69, 10, p. 731-740 10 p.

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7 引文斯高帕斯（Scopus）

Crystal Structures of SgcE6 and SgcC, the Two-Component Monooxygenase That Catalyzes Hydroxylation of a Carrier Protein-Tethered Substrate during the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027 in Streptomyces globisporus

Chang, C-Y., Lohman, J. R., Cao, H., Tan, K., Rudolf, J. D., Ma, M., Xu, W., Bingman, C. A., Yennamalli, R. M., Bigelow, L., Babnigg, G., Yan, X., Joachimiak, A., Phillips, G. N. & Shen, B., 13 9月 2016, 於: Biochemistry. 55, 36, p. 5142-5154 13 p.

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14 引文斯高帕斯（Scopus）

Structure of the ent-Copalyl Diphosphate Synthase PtmT2 from Streptomyces platensis CB00739, a Bacterial Type II Diterpene Synthase

Rudolf, J. D., Dong, L. B., Cao, H., Hatzos-Skintges, C., Osipiuk, J., Endres, M., Chang, C-Y., Ma, M., Babnigg, G., Joachimiak, A., Phillips, G. N. & Shen, B., 31 8月 2016, 於: Journal of the American Chemical Society. 138, 34, p. 10905-10915 11 p.

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39 引文斯高帕斯（Scopus）

2015

Crystal Structure of the Zorbamycin-Binding Protein ZbmA, the Primary Self-Resistance Element in Streptomyces flavoviridis ATCC21892

Rudolf, J. D., Bigelow, L., Chang, C., Cuff, M. E., Lohman, J. R., Chang, C-Y., Ma, M., Yang, D., Clancy, S., Babnigg, G., Joachimiak, A., Phillips, G. N. & Shen, B., 29 10月 2015, 於: Biochemistry. 54, 45, p. 6842-6851 10 p.

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8 引文斯高帕斯（Scopus）

2014

Biosynthesis of streptolidine involved two unexpected intermediates produced by a dihydroxylase and a cyclase through unusual mechanisms

Chang, C-Y., Lyu, S. Y., Liu, Y. C., Hsu, N. S., Wu, C. C., Tang, C. F., Lin, K. H., Ho, J. Y., Wu, C. J., Tsai, M. D. & Li, T. L., 10 2月 2014, 於: Angewandte Chemie - International Edition. 53, 7, p. 1943-1948 6 p.

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33 引文斯高帕斯（Scopus）

Insights into the binding specificity and catalytic mechanism of N-acetylhexosamine 1-phosphate kinases through multiple reaction complexes

Wang, K. C., Lyu, S. Y., Liu, Y. C., Chang, C-Y., Wu, C. J. & Li, T. L., 1 1月 2014, 於: Acta Crystallographica Section D: Biological Crystallography. 70, 5, p. 1401-1410 10 p.

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12 引文斯高帕斯（Scopus）

Multiple complexes of long aliphatic N -acyltransferases lead to synthesis of 2,6-diacylated/2-acyl-substituted glycopeptide antibiotics, effectively killing vancomycin-resistant enterococcus

Lyu, S. Y., Liu, Y. C., Chang, C-Y., Huang, C. J., Chiu, Y. H., Huang, C. M., Hsu, N. S., Lin, K. H., Wu, C. J., Tsai, M. D. & Li, T. L., 6 8月 2014, 於: Journal of the American Chemical Society. 136, 31, p. 10989-10995 7 p.

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16 引文斯高帕斯（Scopus）

Structure and mechanism of a nonhaem-iron SAM-dependent C-methyltransferase and its engineering to a hydratase and an O-methyltransferase

Zou, X. W., Liu, Y. C., Hsu, N. S., Huang, C. J., Lyu, S. Y., Chan, H. C., Chang, C-Y., Yeh, H. W., Lin, K. H., Wu, C. J., Tsai, M. D. & Li, T. L., 1 1月 2014, 於: Acta Crystallographica Section D: Biological Crystallography. 70, 6, p. 1549-1560 12 p.

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19 引文斯高帕斯（Scopus）

2011

Crystal structure and inhibition studies of transglutaminase from Streptomyces mobaraense

Yang, M. T., Chang, C. H., Wang, J. M., Wu, T-K., Wang, Y. K., Chang, C-Y. & Li, T. H. T., 4 3月 2011, 於: Journal of Biological Chemistry. 286, 9, p. 7301-7307 7 p.

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44 引文斯高帕斯（Scopus）

2010

Crystal structure and mutational analysis of aminoacylhistidine dipeptidase from Vibrio alginolyticus reveal a new architecture of M20 metallopeptidases

Chang, C-Y., Hsieh, Y. C., Wang, T. Y., Chen, Y. C., Wang, Y. K., Chiang, T. W., Chen, Y. J., Chang, C. H., Chen, C. J. & Wu, T-K., 10 12月 2010, 於: Journal of Biological Chemistry. 285, 50, p. 39500-39510 11 p.

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13 引文斯高帕斯（Scopus）

2009

Purification, crystallization and preliminary X-ray analysis of an aminoacylhistidine dipeptidase (PepD) from Vibrio alginolyticus

Chang, C-Y., Hsieh, Y. C., Wang, T. Y., Chen, C. J. & Wu, T-K., 13 3月 2009, 於: Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 65, 3, p. 216-218 3 p.

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4 引文斯高帕斯（Scopus）

2008

Expression and characterization of the biofilm-related and carnosine-hydrolyzing aminoacylhistidine dipeptidase from Vibrio alginolyticus

Wang, T. Y., Chen, Y. C., Kao, L. W., Chang, C-Y., Wang, Y. K., Liu, Y. H., Feng, J. M. & Wu, T-K., 1 10月 2008, 於: FEBS Journal. 275, 20, p. 5007-5020 14 p.

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8 引文斯高帕斯（Scopus）

張 晉源

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張晉源