Cheng-Wen Wu

2022

Targeting cancer stemness mediated by BMI1 and MCL1 for non-small cell lung cancer treatment

Lin, E. H., Hsu, J. W., Lee, T. F., Hsu, C. F., Lin, T. H., Jan, Y. H., Chang, H. Y., Cheng, C. M., Hsu, H. J., Chen, W. W., Chen, B. H., Tsai, H. F., Li, J. J., Huang, C. Y., Chuang, S. H., Chang, J. M., Hsiao, M. & Wu, C. W., 2022, (Accepted/In press) 於: Journal of Cellular and Molecular Medicine.

研究成果: Article › 同行評審

開啟存取

2021

Alisertib inhibits migration and invasion of EGFR-TKI resistant cells by partially reversing the epithelial-mesenchymal transition

Wang, C. Y., Lee, M. H., Kao, Y. R., Hsiao, S. H., Hong, S. Y. & Wu, C. W., 5月 2021, 於: Biochimica et Biophysica Acta - Molecular Cell Research. 1868, 6, 119016.

研究成果: Article › 同行評審

6 引文斯高帕斯（Scopus）

TAZ negatively regulates the novel tumor suppressor ANKRD52 and promotes PAK1 dephosphorylation in lung adenocarcinomas

Lee, T. F., Liu, Y. P., Lin, Y. F., Hsu, C. F., Lin, H., Chang, W. C., Pan, C. M., Chou, T. Y. & Wu, C-W., 2月 2021, 於: Biochimica et Biophysica Acta - Molecular Cell Research. 1868, 2, 118891.

研究成果: Article › 同行評審

2 引文斯高帕斯（Scopus）

2020

Low-dose nicotine activates egfr signaling via α5-nAChR and promotes lung adenocarcinoma progression

Wang, M. L., Hsu, Y. F., Liu, C. H., Kuo, Y. L., Chen, Y. C., Yeh, Y. C., Ho, H. L., Wu, Y. C., Chou, T. Y. & Wu, C-W., 2 9月 2020, 於: International journal of molecular sciences. 21, 18, p. 1-18 18 p., 6829.

研究成果: Article › 同行評審

開啟存取

4 引文斯高帕斯（Scopus）

2019

In silico identification of thiostrepton as an inhibitor of cancer stem cell growth and an enhancer for chemotherapy in non–small-cell lung cancer

Huang, T. H., Wu, A. T. H., Cheng, T. S., Lin, K. T., Lai, C. J., Hsieh, H. W., Chang, P. M. H., Wu, C. W., Huang, C. Y. F. & Chen, K. Y., 1 12月 2019, 於: Journal of Cellular and Molecular Medicine. 23, 12, p. 8184-8195 12 p.

研究成果: Article › 同行評審

開啟存取

19 引文斯高帕斯（Scopus）

OCT4B mediates hypoxia-induced cancer dissemination

Lin, S. C., Chung, C. H., Chung, C. H., Kuo, M. H., Hsieh, C. H., Chiu, Y. F., Shieh, Y. S., Chou, Y. T. & Wu, C-W., 14 2月 2019, 於: Oncogene. 38, 7, p. 1093-1105 13 p.

研究成果: Article › 同行評審

8 引文斯高帕斯（Scopus）

Pigment epithelium-derived factor peptide promotes limbal stem cell proliferation through hedgehog pathway

Fan, N. W., Ho, T. C., Wu, C. W. & Tsao, Y. P., 7月 2019, 於: Journal of Cellular and Molecular Medicine. 23, 7, p. 4759-4769 11 p.

研究成果: Article › 同行評審

開啟存取

7 引文斯高帕斯（Scopus）

Pigment epithelium-derived factor peptide reverses mouse age-related meibomian gland atrophy

Fan, N. W., Ho, T. C., Lin, E. H., Wu, C. W., Chien, H. Y. & Tsao, Y. P., 8月 2019, 於: Experimental Eye Research. 185, 107678.

研究成果: Article › 同行評審

5 引文斯高帕斯（Scopus）

2018

EGFR-mediated interleukin enhancer-binding factor 3 contributes to formation and survival of cancer stem-like tumorspheres as a therapeutic target against EGFR-positive non-small cell lung cancer

Cheng, C. C., Chou, K. F., Wu, C-W., Su, N. W., Peng, C. L., Su, Y. W., Chang, J., Ho, A. S., Lin, H. C., Chen, C. G. S., Yang, B. L., Chang, Y. C., Chiang, Y. W., Lim, K. H. & Chang, Y. F., 1 2月 2018, 於: Lung Cancer. 116, p. 80-89 10 p.

研究成果: Article › 同行評審

15 引文斯高帕斯（Scopus）

Enhanced YAP expression leads to EGFR TKI resistance in lung adenocarcinomas

Lee, T. F., Tseng, Y. C., Nguyen, P. A., Li, Y. C., Ho, C. C. & Wu, C-W., 1 12月 2018, 於: Scientific reports. 8, 1, 271.

研究成果: Article › 同行評審

開啟存取

32 引文斯高帕斯（Scopus）

The role of EpCAM in tumor progression and the clinical prognosis of endometrial carcinoma

Wen, K. C., Sung, P. L., Chou, Y. T., Pan, C. M., Wang, P. H., Lee, O. K. S. & Wu, C-W., 1 2月 2018, 於: Gynecologic Oncology. 148, 2, p. 383-392 10 p.

研究成果: Article › 同行評審

25 引文斯高帕斯（Scopus）

Upregulation of E3 ubiquitin ligase CBLC enhances EGFR dysregulation and signaling in lung adenocarcinoma

Hong, S. Y., Kao, Y. R., Lee, T. C. & Wu, C-W., 1 9月 2018, 於: Cancer Research. 78, 17, p. 4984-4996 13 p.

研究成果: Article › 同行評審

27 引文斯高帕斯（Scopus）

2017

A targetable HB-EGF-CITED4 axis controls oncogenesis in lung cancer

Hsieh, C. H., Chou, Y. T., Kuo, M. H., Tsai, H. P., Chang, J. L. & Wu, C. W., 25 5月 2017, 於: Oncogene. 36, 21, p. 2946-2956 11 p.

研究成果: Article › 同行評審

11 引文斯高帕斯（Scopus）

TDP-43/HDAC6 axis promoted tumor progression and regulated nutrient deprivation-induced autophagy in glioblastoma

Lin, T. W., Chen, M. T., Lin, L. T., Huang, P. I., Lo, W. L., Yang, Y. P., Lu, K. H., Chen, Y. W., Chiou, S. H. & Wu, C-W., 1 1月 2017, 於: Oncotarget. 8, 34, p. 56612-56625 14 p.

研究成果: Article › 同行評審

開啟存取

23 引文斯高帕斯（Scopus）

Upregulation of Wnt signaling under hypoxia promotes lung cancer progression

Hong, C. F., Chen, W. Y. & Wu Lee, C-W., 1 9月 2017, 於: Oncology Reports. 38, 3, p. 1706-1714 9 p.

研究成果: Article › 同行評審

開啟存取

24 引文斯高帕斯（Scopus）

YAP1 is essential for tumor growth and is a potential therapeutic target for EGFR-dependent lung adenocarcinomas

Lee, T. F., Tseng, Y. C., Chang, W. C., Chen, Y. C., Kao, Y. R., Chou, T. Y., Ho, C. C. & Wu Lee, C-W., 1 1月 2017, 於: Oncotarget. 8, 52, p. 89539-89551 13 p.

研究成果: Article › 同行評審

開啟存取

12 引文斯高帕斯（Scopus）

YM155 as an inhibitor of cancer stemness simultaneously inhibits autophosphorylation of epidermal growth factor receptor and G9a-mediated stemness in lung cancer cells

Cheng, C. C., Chang, J., Huang, S. C. C., Lin, H. C., Ho, A. S., Lim, K. H., Chang, C. C., Huang, L., Chang, Y. C., Chang, Y. F. & Wu Lee, C-W., 1 8月 2017, 於: PLoS ONE. 12, 8, e0182149.

研究成果: Article › 同行評審

開啟存取

26 引文斯高帕斯（Scopus）

α2,3-sialyltransferase type I regulates migration and peritoneal dissemination of ovarian cancer cells

Wen, K. C., Sung, P. L., Hsieh, S. L., Chou, Y. T., Lee, O. K. S., Wu Lee, C-W. & Wang, P. H., 1 1月 2017, 於: Oncotarget. 8, 17, p. 29013-29027 15 p.

研究成果: Article › 同行評審

開啟存取

36 引文斯高帕斯（Scopus）

2016

Acquisition of tumorigenic potential and enhancement of angiogenesis in pulmonary stem/progenitor cells through Oct-4 hyperexpression

Gu, S. Y., Ho, C. C., Huang, Y. K., Chen, H. W., Wang, Y. C., Kuo, C. Y., Teng, S. C., Fu, W. M., Yang, P. C., Wu, C-W., Peng, F. C. & Ling, T. Y., 22 3月 2016, 於: Oncotarget. 7, 12, p. 13917-13931 15 p.

研究成果: Article › 同行評審

開啟存取

3 引文斯高帕斯（Scopus）

Epigenetic switch between SOX2 and SOX9 regulates cancer cell plasticity

Lin, S. C., Chou, Y. T., Jiang, S. S., Chang, J. L., Chung, C. H., Kao, Y. R., Chang, I. S. & Wu, C-W., 1 12月 2016, 於: Cancer Research. 76, 23, p. 7036-7048 13 p.

研究成果: Article › 同行評審

開啟存取

33 引文斯高帕斯（Scopus）

Hedgehog pathway maintains cell survival under stress conditions, and drives drug resistance in lung adenocarcinoma

Lin, E. H., Kao, Y. R., Lin, C. A., Kuo, T. Y., Yang, S. P., Hsu, C. F., Chou, T. Y., Ho, C. C. & Wu Lee, C-W., 26 4月 2016, 於: Oncotarget. 7, 17, p. 24179-24193 15 p.

研究成果: Article › 同行評審

開啟存取

34 引文斯高帕斯（Scopus）

MicroRNA-7 compromises p53 protein-dependent apoptosis by controlling the expression of the chromatin remodeling factor SMARCD1

Hong, C. F., Lin, S. Y., Chou, Y. T. & Wu Lee, C-W., 22 1月 2016, 於: Journal of Biological Chemistry. 291, 4, p. 1877-1889 13 p.

研究成果: Article › 同行評審

開啟存取

26 引文斯高帕斯（Scopus）

Oncostatin M suppresses metastasis of lung adenocarcinoma by inhibiting SLUG expression through coordination of STATs and PIASs signalings

Pan, C. M., Wang, M. L., Chiou, S. H., Chen, H. Y. & Wu Lee, C-W., 1 1月 2016, 於: Oncotarget. 7, 37, p. 60395-60406 12 p.

研究成果: Article › 同行評審

開啟存取

24 引文斯高帕斯（Scopus）

2015

Galectin-3 modulates the EGFR signalling-mediated regulation of Sox2 expression via c-Myc in lung cancer

Kuo, H. Y., Hsu, H. T., Chen, Y. C., Chang, Y. W., Liu, F. T. & Wu, C-W., 18 5月 2015, 於: Glycobiology. 26, 2, p. 155-165 11 p.

研究成果: Article › 同行評審

開啟存取

35 引文斯高帕斯（Scopus）

Protein tyrosine phosphatase PTPN3 inhibits lung cancer cell proliferation and migration by promoting EGFR endocytic degradation

Li, M. Y., Lai, P. L., Chou, Y. T., Chi, A. P., Mi, Y. Z., Khoo, K. H., Chang, G. D., Wu, C. W., Meng, T. C. & Chen, G. C., 21 7月 2015, 於: Oncogene. 34, 29, p. 3791-3803 13 p.

研究成果: Article › 同行評審

開啟存取

39 引文斯高帕斯（Scopus）

YM500v2: A small RNA sequencing (smRNA-seq) database for human cancer miRNome research

Cheng, W. C., Chung, I. F., Tsai, C. F., Huang, T. S., Chen, C. Y., Wang, S. C., Chang, T. Y., Sun, H. J., Chao, J. Y. C., Cheng, C. C., Wu, C-W. & Wang, H. W., 15 1月 2015, 於: Nucleic acids research. 43, D1, p. D862-D867

研究成果: Article › 同行評審

開啟存取

43 引文斯高帕斯（Scopus）

2014

FOXF1 mediates mesenchymal stem cell fusion-induced reprogramming of lung cancer cells

Wei, H. J., Nickoloff, J. A., Chen, W. H., Liu, H. Y., Lo, W. C., Chang, Y. T., Yang, P. C., Wu, C-W., Williams, D. F., Gelovani, J. G. & Deng, W. P., 1 1月 2014, 於: Oncotarget. 5, 19, p. 9514-9529 16 p.

研究成果: Article › 同行評審

開啟存取

59 引文斯高帕斯（Scopus）

PML represses lung cancer metastasis by suppressing the nuclear EGFR-mediated transcriptional activation of MMP2

Kuo, H. Y., Huang, Y. S., Tseng, C. H., Chen, Y. C., Chang, Y. W., Shih, H. M. & Wu, C-W., 1 10月 2014, 於: Cell Cycle. 13, 19, p. 3132-3142 11 p.

研究成果: Article › 同行評審

19 引文斯高帕斯（Scopus）

2013

Improvement of ventilator-induced lung injury by IPS cell-derived conditioned medium via inhibition of PI3K/Akt pathway and IP-10-dependent paracrine regulation

Li, L. F., Liu, Y. Y., Yang, C. T., Chien, Y., Twu, N. F., Wang, M. L., Wang, C. Y., Huang, C. C., Kao, K. C., Hsu, H. S., Wu Lee, C-W. & Chiou, S. H., 1 1月 2013, 於: Biomaterials. 34, 1, p. 78-91 14 p.

研究成果: Article › 同行評審

40 引文斯高帕斯（Scopus）

Polyethyleneimine and DNA nanoparticles-based gene therapy for acute lung injury

Lin, E. H., Chang, H. Y., Yeh, S. D., Yang, K. Y., Hu, H. S. & Wu Lee, C-W., 1 11月 2013, 於: Nanomedicine: Nanotechnology, Biology, and Medicine. 9, 8, p. 1293-1303 11 p.

研究成果: Article › 同行評審

24 引文斯高帕斯（Scopus）

The emerging role of SOX2 in cell proliferation and survival and its crosstalk with oncogenic signaling in lung cancer

Chou, Y. T., Lee, C. C., Hsiao, S. H., Lin, S. E., Lin, S. C., Chung, C. H., Chung, C. H., Kao, Y. R., Wang, Y. H., Chen, C. T., Wei, Y. H. & Wu, C-W., 1 12月 2013, 於: Stem Cells. 31, 12, p. 2607-2619 13 p.

研究成果: Article › 同行評審

開啟存取

93 引文斯高帕斯（Scopus）

The PML isoform IV is a negative regulator of nuclear EGFR's transcriptional activity in lung cancer

Kuo, H. Y., Chen, Y. C., Chang, H. Y., Jeng, J. C., Lin, E. H., Pan, C. M., Chang, Y. W., Wang, M. L., Chou, Y. T., Shih, H. M. & Wu Lee, C-W., 1 8月 2013, 於: Carcinogenesis. 34, 8, p. 1708-1716 9 p.

研究成果: Article › 同行評審

開啟存取

15 引文斯高帕斯（Scopus）

2012

CITED2 functions as a molecular switch of cytokine-induced proliferation and quiescence

Chou, Y. T., Hsieh, C. H., Chiou, S. H., Hsu, C. F., Kao, Y. R., Lee, C. C., Chung, C. H., Wang, Y. H., Hsu, H. S., Pang, S. T., Shieh, Y. S. & Wu Lee, C-W., 1 12月 2012, 於: Cell Death and Differentiation. 19, 12, p. 2015-2028 14 p.

研究成果: Article › 同行評審

開啟存取

45 引文斯高帕斯（Scopus）

Oncostatin M modulates the mesenchymal-epithelial transition of lung adenocarcinoma cells by a mesenchymal stem cell-mediated paracrine effect

Wang, M. L., Pan, C. M., Chiou, S. H., Chen, W. H., Chang, H. Y., Lee, O. K. S., Hsu, H. S. & Wu Lee, C-W., 15 11月 2012, 於: Cancer Research. 72, 22, p. 6051-6064 14 p.

研究成果: Article › 同行評審

開啟存取

44 引文斯高帕斯（Scopus）

Suppression of the invasion and migration of cancer cells by SERPINB family genes and their derived peptides

Chou, R. H., Wen, H. C., Liang, W. G., Lin, S. C., Yuan, H. W., Wu, C-W. & Chang, W. S. W., 1 1月 2012, 於: Oncology Reports. 27, 1, p. 238-245 8 p.

研究成果: Article › 同行評審

開啟存取

46 引文斯高帕斯（Scopus）

2011

Cancer-targeted BikDD gene therapy elicits protective antitumor immunity against lung cancer

Sher, Y. P., Liu, S. J., Chang, C. M., Lien, S. P., Chen, C. H., Han, Z., Li, L. Y., Chen, J. S., Wu Lee, C-W. & Hung, M. C., 1 4月 2011, 於: Molecular Cancer Therapeutics. 10, 4, p. 637-647 11 p.

研究成果: Article › 同行評審

開啟存取

14 引文斯高帕斯（Scopus）

Epigenetic activation of human kallikrein 13 enhances malignancy of lung adenocarcinoma by promoting N-cadherin expression and laminin degradation

Chou, R. H., Lin, S. C., Wen, H. C., Wu, C-W. & Chang, W. S. W., 10 6月 2011, 於: Biochemical and Biophysical Research Communications. 409, 3, p. 442-447 6 p.

研究成果: Article › 同行評審

26 引文斯高帕斯（Scopus）

Lifelong reporter gene imaging in the lungs of mice following polyethyleneimine-mediated sleeping-beauty transposon delivery

Lin, E. H., Keramidas, M., Rome, C., Chiu, W. T., Wu Lee, C-W., Coll, J. L. & Deng, W. P., 1 1月 2011, 於: Biomaterials. 32, 7, p. 1978-1985 8 p.

研究成果: Article › 同行評審

12 引文斯高帕斯（Scopus）

2010

Coexpression of Oct4 and Nanog enhances malignancy in lung adenocarcinoma by inducing cancer stem cell-like properties and epithelial-mesenchymal transdifferentiation

Chiou, S. H., Wang, M. L., Chou, Y. T., Chen, C. J., Hong, C. F., Hsieh, W. J., Chang, H. T., Chen, Y. S., Lin, T. W., Hsu, H. S. & Wu Lee, C-W., 15 12月 2010, 於: Cancer Research. 70, 24, p. 10433-10444 12 p.

研究成果: Article › 同行評審

開啟存取

514 引文斯高帕斯（Scopus）

EGFR promotes lung tumorigenesis by activating miR-7 through a Ras/ERK/Myc pathway that targets the Ets2 transcriptional repressor ERF

Chou, Y. T., Lin, H. H., Lien, Y. C., Wang, Y. H., Hong, C. F., Kao, Y. R., Lin, S. C., Chang, Y. C., Lin, S. Y., Chen, S. J., Chen, H. C., Yeh, S. D. & Wu Lee, C-W., 1 11月 2010, 於: Cancer Research. 70, 21, p. 8822-8831 10 p.

研究成果: Article › 同行評審

開啟存取

234 引文斯高帕斯（Scopus）

hNaa10p contributes to tumorigenesis by facilitating DNMT1-mediated tumor suppressor gene silencing

Lee, C. F., Ou, D. S. C., Lee, S. B., Chang, L. H., Lin, R. K., Li, Y. S., Upadhyay, A. K., Cheng, X., Wang, Y. C., Hsu, H. S., Hsiao, M., Wu Lee, C-W. & Juan, L. J., 2 8月 2010, 於: Journal of Clinical Investigation. 120, 8, p. 2920-2930 11 p.

研究成果: Article › 同行評審

開啟存取

86 引文斯高帕斯（Scopus）

Identification of a new peptide for fibrosarcoma tumor targeting and imaging in vivo

Wu, C. C., Lin, E. H., Lee, Y. C., Tai, C. J., Kuo, T. H., Wang, H. E., Luo, T. Y., Fu, Y. K., Chen, H. J., Sun, M. D., Wu, C. H., Wu, C-W., Leu, S. J. & Deng, W. P., 1 12月 2010, 於: Journal of Biomedicine and Biotechnology. 2010, 167045.

研究成果: Article › 同行評審

開啟存取

3 引文斯高帕斯（Scopus）

The investigation of mitogen-activated protein kinase phosphatase-1 as a potential pharmacological target in non-small cell lung carcinomas, assisted by non-invasive molecular imaging

Tai, C. J., Wu, A. T. H., Chiou, J. F., Jan, H. J., Wei, H. J., Hsu, C. H., Lin, C. T., Chiu, W. T., Wu Lee, C-W., Lee, H. M. & Deng, W. P., 12 3月 2010, 於: BMC Cancer. 10, 95.

研究成果: Article › 同行評審

開啟存取

32 引文斯高帕斯（Scopus）

Upregulation of SOX9 in lung adenocarcinoma and its involvement in the regulation of cell growth and tumorigenicity

Jiang, S. S., Fang, W. T., Hou, Y. H., Huang, S. F., Yen, B. L., Chang, J. L., Li, S. M., Liu, H. P., Liu, Y. L., Huang, C. T., Li, Y. W., Jang, T. H., Chan, S. H., Yang, S. J., Hsiung, C. A., Wu, C-W., Wang, L. H. & Chang, I. S., 1 9月 2010, 於: Clinical Cancer Research. 16, 17, p. 4363-4373 11 p.

研究成果: Article › 同行評審

開啟存取

110 引文斯高帕斯（Scopus）

2009

c-Myc regulates the coordinated transcription of brain disease-related PDCD10-SERPINI1 bidirectional gene pair

Chen, P. Y., Chang, W. S. W., Lai, Y. K. & Wu Lee, C-W., 1 8月 2009, 於: Molecular and Cellular Neuroscience. 42, 1, p. 23-32 10 p.

研究成果: Article › 同行評審

17 引文斯高帕斯（Scopus）

MAD2B, a novel TCF4-binding protein, modulates TCF4-mediated epithelial-mesenchymal transdifferentiation

Hong, C. F., Chou, Y. T., Lin, Y. S. & Wu, C-W., 17 7月 2009, 於: Journal of Biological Chemistry. 284, 29, p. 19613-19622 10 p.

研究成果: Article › 同行評審

開啟存取

34 引文斯高帕斯（Scopus）

The involvement of promoter methylation and DNA methyltransferase-1 in the regulation of EpCAM expression in oral squamous cell carcinoma

Shiah, S. G., Chang, L. C., Tai, K. Y., Lee, G. H., Wu Lee, C-W. & Shieh, Y. S., 1 1月 2009, 於: Oral Oncology. 45, 1

研究成果: Article › 同行評審

22 引文斯高帕斯（Scopus）

2008

Axl promotes cell invasion by inducing MMP-9 activity through activation of NF-κB and Brg-1

Tai, K. Y., Shieh, Y. S., Lee, C. S., Shiah, S. G. & Wu, C-W., 3 7月 2008, 於: Oncogene. 27, 29, p. 4044-4055 12 p.

研究成果: Article › 同行評審

開啟存取

133 引文斯高帕斯（Scopus）

Insulin-like growth factor binding protein-3 (IGFBP-3) acts as an invasion-metastasis suppressor in ovarian endometrioid carcinoma

Torng, P. L., Lee, Y. C. G., Huang, C. Y. F., Ye, J. H., Lin, Y. S., Chu, Y. W., Huang, S. C., Cohen, P., Wu Lee, C-W. & Lin, C. T., 3 4月 2008, 於: Oncogene. 27, 15, p. 2137-2147 11 p.

研究成果: Article › 同行評審

開啟存取

62 引文斯高帕斯（Scopus）

2007

DNA methylation and histone modification regulate silencing of epithelial cell adhesion molecule for tumor invasion and progression

Tai, K. Y., Shiah, S. G., Shieh, Y. S., Kao, Y. R., Chi, C. Y., Huang, E., Lee, H. S., Chang, L. C., Yang, P. C. & Wu Lee, C-W., 7 6月 2007, 於: Oncogene. 26, 27, p. 3989-3997 9 p.

研究成果: Article › 同行評審

開啟存取

54 引文斯高帕斯（Scopus）

吳 成文

研究成果

搜尋結果

吳成文