Ao-Lin Hsu

2023

Activation of eIF4E-binding-protein-1 rescues mTORC1-induced sarcopenia by expanding lysosomal degradation capacity

Crombie, E. M., Kim, S., Adamson, S., Dong, H., Lu, T. C., Wu, Y., Wu, Y., Levy, Y., Stimple, N., Lam, W. M. R., Hey, H. W. D., Withers, D. J., Hsu, A. L., Bay, B. H., Ochala, J. & Tsai, S. Y., 2月 2023, 於: Journal of Cachexia, Sarcopenia and Muscle. 14, 1, p. 198-213 16 p.

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3 引文斯高帕斯（Scopus）

2022

Development of a traditional Chinese medicine-based agent for the treatment of cancer cachexia

Wu, K. C., Chu, P. C., Cheng, Y. J., Li, C. I., Tian, J., Wu, H. Y., Wu, S. H., Lai, Y. C., Kao, H. H., Hsu, A. L., Lin, H. W. & Lin, C. H., 2022, (Accepted/In press) 於: Journal of Cachexia, Sarcopenia and Muscle.

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3 引文斯高帕斯（Scopus）

SAMS-1 coordinates HLH-30/TFEB and PHA-4/FOXA activities through histone methylation to mediate dietary restriction-induced autophagy and longevity

Lim, C. Y., Lin, H. T., Kumsta, C., Lu, T. C., Wang, F. Y., Kang, Y. H., Hansen, M., Ching, T. T. & Hsu, A-L., 2022, (Accepted/In press) 於: Autophagy.

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3 引文斯高帕斯（Scopus）

2021

A maze platform for the assessment of Caenorhabditis elegans behavior and learning

Gourgou, E. & Hsu, A-L., 17 12月 2021, 於: STAR Protocols. 2, 4, 100829.

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1 引文斯高帕斯（Scopus）

Caenorhabditis elegans learning in a structured maze is a multisensory behavior

Gourgou, E., Adiga, K., Goettemoeller, A., Chen, C. & Hsu, A-L., 23 4月 2021, 於: iScience. 24, 4, 102284.

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12 引文斯高帕斯（Scopus）

Using convolutional neural network to measure the physiological age of Caenorhabditis elegans

Lin, J. L., Kuo, W-L., Huang, Y. H., Jong, T. L., Hsu, A-L. & Hsu, W. H., 8 12月 2021, 於: IEEE/ACM Transactions on Computational Biology and Bioinformatics. 18, 6, p. 2724-2732

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6 引文斯高帕斯（Scopus）

2020

AMPK-mediated formation of stress granules is required for dietary restriction-induced longevity in Caenorhabditis elegans

Kuo, C. T., You, G. T., Jian, Y. J., Chen, T. S., Siao, Y. C., Hsu, A. L. & Ching, T. T., 1 6月 2020, 於: Aging Cell. 19, 6, e13157.

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16 引文斯高帕斯（Scopus）

High-throughput small molecule screening reveals Nrf2-dependent and -independent pathways of cellular stress resistance

Lombard, D. B., Kohler, W. J., Guo, A. H., Gendron, C., Han, M., Ding, W., Lyu, Y., Ching, T. T., Wang, F. Y., Chakraborty, T. S., Nikolovska-Coleska, Z., Duan, Y., Girke, T., Hsu, A. L., Pletcher, S. D. & Miller, R. A., 30 9月 2020, 於: Science Advances. 6, 40, eaaz7628.

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10 引文斯高帕斯（Scopus）

HSB-1/HSF-1 pathway modulates histone H4 in mitochondria to control mtDNA transcription and longevity

Sural, S., Liang, C. Y., Wang, F. Y., Ching, T. T. & Hsu, A. L., 21 10月 2020, 於: Science Advances. 6, 43, aaz4452.

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14 引文斯高帕斯（Scopus）

S-adenosyl methionine synthetase SAMS-5 mediates dietary restriction-induced longevity in Caenorhabditis elegans

Chen, C. C., Lim, C. Y., Lee, P. J., Hsu, A. L. & Ching, T. T., 11月 2020, 於: PLoS ONE. 15, 11 November, e0241455.

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3 引文斯高帕斯（Scopus）

Short-term enhancement of motor neuron synaptic exocytosis during early aging extends lifespan in Caenorhabditis elegans

Ching, T. T., Chen, Y. C., Li, G., Liu, J., Xu, XZ. S. & Hsu, A. L., 1 11月 2020, 於: Experimental Biology and Medicine. 245, 17, p. 1552-1559 8 p.

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2 引文斯高帕斯（Scopus）

2019

DAF-16 stabilizes the aging transcriptome and is activated in mid-aged Caenorhabditis elegans to cope with internal stress

Li, S. T., Zhao, H. Q., Zhang, P., Liang, C. Y., Zhang, Y. P., Hsu, A. L. & Dong, M. Q., 6月 2019, 於: Aging Cell. 18, 3, e12896.

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33 引文斯高帕斯（Scopus）

Genetic and pharmacological interventions in the aging motor nervous system slow motor aging and extend life span in C. elegans

Li, G., Gong, J., Liu, J., Liu, J., Li, H., Hsu, A. L., Liu, J. & Shawn Xu, X. Z., 2019, 於: Science Advances. 5, 1, eaau5041.

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14 引文斯高帕斯（Scopus）

HSB-1 inhibition and HSF-1 overexpression trigger overlapping transcriptional changes to promote longevity in Caenorhabditis elegans

Sural, S., Lu, T. C., Jung, S. A. & Hsu, A. L., 1 5月 2019, 於: G3: Genes, Genomes, Genetics. 9, 5, p. 1679-1692 14 p.

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18 引文斯高帕斯（Scopus）

2018

Prefoldin 6 mediates longevity response from heat shock factor 1 to FOXO in C. elegans

Son, H. G., Seo, K., Seo, M., Park, S., Ham, S., An, S. W. A., Choi, E. S., Lee, Y., Baek, H., Kim, E., Ryu, Y., Ha, C. M., Hsu, A. L., Roh, T. Y., Jang, S. K. & Lee, S. J. V., 1 12月 2018, 於: Genes and Development. 32, 23-24, p. 1562-1575 14 p.

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19 引文斯高帕斯（Scopus）

2016

Reciprocal changes in phosphoenolpyruvate carboxykinase and pyruvate kinase with age are a determinant of aging in Caenorhabditis elegans

Yuan, Y., Hakimi, P., Kao, C., Kao, A., Liu, R., Janocha, A., Boyd-Tressler, A., Hang, X., Alhoraibi, H., Slater, E., Xia, K., Cao, P., Shue, Q., Ching, T. T., Hsu, A. L., Erzurum, S. C., Dubyak, G. R., Berger, N. A., Hanson, R. W. & Feng, Z., 15 1月 2016, 於: Journal of Biological Chemistry. 291, 3, p. 1307-1319 13 p.

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25 引文斯高帕斯（Scopus）

2015

Analysis of lifespan-promoting effect of garlic extract by an integrated metabolo-proteomics approach

Huang, C. H., Hsu, F. Y., Wu, Y. H., Zhong, L., Tseng, M. Y., Kuo, C. J., Hsu, A. L., Liang, S. S. & Chiou, S. H., 1 8月 2015, 於: Journal of Nutritional Biochemistry. 26, 8, p. 808-817 10 p.

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20 引文斯高帕斯（Scopus）

Co-chaperone p23 Regulates C. elegans Lifespan in Response to Temperature

Horikawa, M., Sural, S., Hsu, A. L. & Antebi, A., 1 4月 2015, 於: PLoS Genetics. 11, 4, e1005023.

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30 引文斯高帕斯（Scopus）

Environmental Temperature Differentially Modulates C. elegans Longevity through a Thermosensitive TRP Channel

Zhang, B., Xiao, R., Ronan, E. A., He, Y., Hsu, A. L., Liu, J. & Xu, X. Z. S., 9 6月 2015, 於: Cell Reports. 11, 9, p. 1414-1424 11 p.

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67 引文斯高帕斯（Scopus）

Monitoring newly synthesized proteins over the adult life span of Caenorhabditis elegans

Vukoti, K., Yu, X., Sheng, Q., Saha, S., Feng, Z., Hsu, A. L. & Miyagi, M., 6 3月 2015, 於: Journal of Proteome Research. 14, 3, p. 1483-1494 12 p.

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21 引文斯高帕斯（Scopus）

2014

Integrin-linked kinase modulates longevity and thermotolerance in C. elegans through neuronal control of HSF-1

Kumsta, C., Ching, T. T., Nishimura, M., Davis, A. E., Gelino, S., Catan, H. H., Yu, X., Chu, C. C., Ong, B., Panowski, S. H., Baird, N., Bodmer, R., Hsu, A. L. & Hansen, M., 6月 2014, 於: Aging Cell. 13, 3, p. 419-430 12 p.

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36 引文斯高帕斯（Scopus）

2013

Functional aging in the nervous system contributes to age-dependent motor activity decline in C. elegans

Liu, J., Zhang, B., Lei, H., Feng, Z., Liu, J., Hsu, A. L. & Xu, X. Z. S., 3 9月 2013, 於: Cell Metabolism. 18, 3, p. 392-402 11 p.

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89 引文斯高帕斯（Scopus）

2012

C. elegans SIRT6/7 Homolog SIR-2.4 Promotes DAF-16 Relocalization and Function during Stress

Chiang, W. C., Tishkoff, D. X., Yang, B., Wilson-Grady, J., Yu, X., Mazer, T., Eckersdorff, M., Gygi, S. P., Lombard, D. B. & Hsu, A. L., 9月 2012, 於: PLoS Genetics. 8, 9, e1002948.

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50 引文斯高帕斯（Scopus）

Enhanced energy metabolism contributes to the extended life span of calorie-restricted Caenorhabditis elegans

Yuan, Y., Kadiyala, C. S., Ching, T. T., Hakimi, P., Saha, S., Xu, H., Yuan, C., Mullangi, V., Wang, L., Fivenson, E., Hanson, R. W., Ewing, R., Hsu, A. L., Miyagi, M. & Feng, Z., 7 9月 2012, 於: Journal of Biological Chemistry. 287, 37, p. 31414-31426 13 p.

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49 引文斯高帕斯（Scopus）

HSF-1 regulators DDL-1/2 link insulin-like signaling to heat-shock responses and modulation of longevity

Chiang, W. C., Ching, T. T., Lee, H. C., Mousigian, C. & Hsu, A. L., 20 1月 2012, 於: Cell. 148, 1-2, p. 322-334 13 p.

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163 引文斯高帕斯（Scopus）

2011

Celecoxib extends C. elegans lifespan via inhibition of insulin-like signaling but not cyclooxygenase-2 activity

Ching, T. T., Chiang, W. C., Chen, C. S. & Hsu, A. L., 6月 2011, 於: Aging Cell. 10, 3, p. 506-519 14 p.

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42 引文斯高帕斯（Scopus）

Solid plate-based dietary restriction in Caenorhabditis elegans.

Ching, T-T. & Hsu, A-L., 28 5月 2011, 於: Journal of Visualized Experiments. 51, e2701.

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13 引文斯高帕斯（Scopus）

2010

Drr-2 encodes an eIF4H that acts downstream of TOR in diet-restriction-induced longevity of C. elegans

Ching, T. T., Paal, A. B., Mehta, A., Zhong, L. & Hsu, A. L., 8月 2010, 於: Aging Cell. 9, 4, p. 545-557 13 p.

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42 引文斯高帕斯（Scopus）

2009

Identification by machine vision of the rate of motor activity decline as a lifespan predictor in C. elegans

Hsu, A. L., Feng, Z., Hsieh, M. Y. & Xu, X. Z. S., 9月 2009, 於: Neurobiology of Aging. 30, 9, p. 1498-1503 6 p.

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81 引文斯高帕斯（Scopus）

2005

New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen

Hansen, M., Hsu, A. L., Dillin, A. & Kenyon, C., 7月 2005, 於: PLoS Genetics. 1, 1, p. 119-128 10 p.

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388 引文斯高帕斯（Scopus）

2003

Regulation of aging and age-related disease by DAF-16 and heat-shock factor

Hsu, A. L., Murphy, C. T. & Kenyon, C., 16 5月 2003, 於: Science. 300, 5622, p. 1142-1145 4 p.

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1154 引文斯高帕斯（Scopus）

2002

Genetic analysis of tissue aging in Caenorhabditis elegans: A role for heat-shock factor and bacterial proliferation

Garigan, D., Hsu, A. L., Fraser, A. G., Kamath, R. S., Abringet, J. & Kenyon, C., 7月 2002, 於: Genetics. 161, 3, p. 1101-1112 12 p.

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601 引文斯高帕斯（Scopus）

Rates of behavior and aging specified by mitochondrial function during development

Dillin, A., Hsu, A. L., Arantes-Oliveira, N., Lehrer-Graiwer, J., Hsin, H., Fraser, A. G., Kamath, R. S., Ahringer, J. & Kenyon, C., 20 12月 2002, 於: Science. 298, 5602, p. 2398-2401 4 p.

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813 引文斯高帕斯（Scopus）

The cyclo-oxygenase-2 inhibitor celecoxib perturbs intracellular calcium by inhibiting endoplasmic reticulum Ca²⁺-ATPases: A plausible link with its anti-tumour effect and cardiovascular risks

Johnson, A. J., Hsu, A. L., Lin, H. P., Song, X. & Chen, C. S., 15 9月 2002, 於: Biochemical Journal. 366, 3, p. 831-837 7 p.

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141 引文斯高帕斯（Scopus）

2001

A phosphatidylinositol 3,4,5-trisphosphate analogue with low serum protein-binding affinity

Wang, D. S., Hsu, A. L. & Chen, C. S., 2001, 於: Bioorganic and Medicinal Chemistry. 9, 1, p. 133-139 7 p.

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10 引文斯高帕斯（Scopus）

Apoptosis signaling pathways mediated by cyclooxygenase-2 inhibitors in prostate cancer cells

Johnson, A. J., Song, X., Hsu, A. L. & Chen, C. S., 2001, 於: Advances in Enzyme Regulation. 41, 1, p. 221-235 15 p.

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64 引文斯高帕斯（Scopus）

Phosphoinositide 3-Kinase Facilitates Antigen-stimulated Ca²⁺ Influx in RBL-2H3 Mast Cells via a Phosphatidylinositol 3,4,5-Trisphosphate-sensitive Ca²⁺ Entry Mechanism

Ching, T. T., Hsu, A. L., Johnson, A. J. & Chen, C. S., 4 5月 2001, 於: Journal of Biological Chemistry. 276, 18, p. 14814-14820 7 p.

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77 引文斯高帕斯（Scopus）

2000

Novel function of phosphoinositide 3-kinase in T cell Ca²⁺ signaling: A phosphatidylinositol 3,4,5-trisphosphate-mediated Ca²⁺ entry mechanism

Hsu, A. L., Ching, T. T., Sen, G., Wang, D. S., Bondada, S., Authi, K. S. & Chen, C. S., 26 5月 2000, 於: Journal of Biological Chemistry. 275, 21, p. 16242-16250 9 p.

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54 引文斯高帕斯（Scopus）

The cyclooxygenase-2 inhibitor celecoxib induces apoptosis by blocking Akt activation in human prostate cancer cells independently of Bcl-2

Hsu, A. L., Ching, T. T., Wang, D. S., Song, X., Rangnekar, V. M. & Chen, C. S., 14 4月 2000, 於: Journal of Biological Chemistry. 275, 15, p. 11397-11403 7 p.

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648 引文斯高帕斯（Scopus）

1999

Identification of multiple phosphoinositide-specific phospholipases D as new regulatory enzymes for phosphatidylinositol 3,4,5-trisphosphate

Ching, T. T., Wang, D. S., Hsu, A. L., Lu, P. J. & Chen, C. S., 26 3月 1999, 於: Journal of Biological Chemistry. 274, 13, p. 8611-8617 7 p.

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22 引文斯高帕斯（Scopus）

1998

Molecular Recognition at the Phosphatidylinositol 3,4,5-Trisphosphate-Binding Site. Studies Using the Permuted Isomers of Phosphatidylinositol Trisphosphate

Wang, D. S., Hsu, A. L., Song, X., Chiou, C. M. & Chen, C. S., 7 8月 1998, 於: Journal of Organic Chemistry. 63, 16, p. 5430-5437 8 p.

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13 引文斯高帕斯（Scopus）

Phosphatidylinositol 3,4,5-trisphosphate triggers platelet aggregation by activating Ca²⁺ influx

Lu, P. J., Hsu, A. L., Wang, D. S. & Chen, C. S., 7 7月 1998, 於: Biochemistry. 37, 27, p. 9776-9783 8 p.

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32 引文斯高帕斯（Scopus）

Phosphoinositide 3-kinase in rat liver nuclei

Lu, P. J., Hsu, A. L., Wang, D. S., Yan, H. Y., Yin, H. L. & Chen, C. S., 21 4月 1998, 於: Biochemistry. 37, 16, p. 5738-5745 8 p.

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73 引文斯高帕斯（Scopus）

Regulation of nuclear calcium uptake by inositol phosphates and external calcium

Hsu, A. L., Lu, P. J. & Chen, C. S., 24 2月 1998, 於: Biochemical and Biophysical Research Communications. 243, 3, p. 653-656 4 p.

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13 引文斯高帕斯（Scopus）

1997

Nuclear calcium regulation by inositol phosphates and cyclic ADP-ribose

Hsu, A. L., Lu, P. J. & Chen, C. S., 1 12月 1997, 於: FASEB Journal. 11, 9, p. A1173

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1995

Characterization of γ-crystallin from a catfish: Structural characterization of one major isoform with high methionine by cDNA sequencing

Pan, F. M., Chang, W. C., Lin, C. H., Hsu, A. L. & Chiou, S. H., 1995, 於: Biochemistry and Molecular Biology International. 35, 4, p. 725-732 8 p.

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8 引文斯高帕斯（Scopus）

Sequence analysis of one major basic β-crystallin (β-Bp) of amphibian lenses: Evolutionary comparison and phylogenetic relatedness between β-crystallin and γ-crystallin

Pan, F. M., Chang, W. C., Lu, S. F., Hsu, A. L. & Chiou, S. H., 26 12月 1995, 於: Biochemical and Biophysical Research Communications. 217, 3, p. 940-949 10 p.

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7 引文斯高帕斯（Scopus）

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