生化暨分子生物研究所

2024

Aldo-keto reductase family member C3 (AKR1C3) promotes hepatocellular carcinoma cell growth by producing prostaglandin F2α

Jeng, K. S., Cheng, P. Y., Lin, Y. H., Liu, P. C., Tseng, P.-H., Wang, Y. C., Chang, C. F. & Leu, C. M., 2024, 於: Oncology Research. 32, 1, p. 163-174 12 p.

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3 引文斯高帕斯（Scopus）

Analysis of Human Endogenous mRNA Deadenylation Complexes by High-Resolution Gel Electrophoresis

Chang, C. T., 2024, Methods in Molecular Biology. Humana Press Inc., p. 47-54 8 p. (Methods in Molecular Biology; 卷 2723).

研究成果: Chapter › 同行評審

Correction: PTPN23 ubiquitination by WDR4 suppresses EGFR and c-MET degradation to define a lung cancer therapeutic target (Cell Death & Disease, (2023), 14, 10, (671), 10.1038/s41419-023-06201-4)

Singh, S., Yeat, N. Y., Wang, Y. T., Lin, S. Y., Kuo, I. Y., Wu, K. P., Wang, W. J., Wang, W. C., Su, W. C., Wang, Y. C. & Chen, R. H., 7月 2024, 於: Cell Death and Disease. 15, 7, 468.

研究成果: Comment/debate

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DNA-modified Prussian blue nanozymes for enhanced electrochemical biosensing

Huang, L. H., Hsieh, Y. Y., Yang, F. A. & Liao, W. C., 10 4月 2024, 於: Nanoscale. 16, 20, p. 9770-9780 11 p.

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1 引文斯高帕斯（Scopus）

Galectin-3 aggravates microglial activation and tau transmission in tauopathy

Siew, J. J., Chen, H. M., Chiu, F. L., Lee, C. W., Chang, Y. M., Chen, H. L., Nguyen, T. N. A., Liao, H. T., Liu, M., Hagar, H. T., Sun, Y. C., Lai, H. L., Kuo, M. H., Blum, D., Buée, L., Jin, L. W., Chen, S. Y., Ko, T. M., Huang, J. R. & Kuo, H. C. 及其他2, Liu, F. T. & Chern, Y., 16 1月 2024, 於: Journal of Clinical Investigation. 134, 2, e165523.

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4 引文斯高帕斯（Scopus）

High-viscosity driven modulation of biomechanical properties of human mesenchymal stem cells promotes osteogenic lineage

Chen, Y. Q., Wu, M. C., Wei, M. T., Kuo, J. C., Yu, H. W. & Chiou, A., 6月 2024, 於: Materials Today Bio. 26, 101058.

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3 引文斯高帕斯（Scopus）

Human DDX6 regulates translation and decay of inefficiently translated mRNAs

Weber, R. & Chang, C. T., 2024, 於: eLife. 13, RP92426.

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1 引文斯高帕斯（Scopus）

Matrix mechanics regulates muscle regeneration by modulating kinesin-1 activity

Chiang, W. Y., Yu, H. W., Wu, M. C., Huang, Y. M., Chen, Y. Q., Lin, J. W., Liu, Y. W., You, L. R., Chiou, A. & Kuo, J. C., 7月 2024, 於: Biomaterials. 308, 122551.

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3 引文斯高帕斯（Scopus）

Mitochondrial S-adenosylmethionine deficiency induces mitochondrial unfolded protein response and extends lifespan in Caenorhabditis elegans

Chen, T. Y., Wang, F. Y., Lee, P. J., Hsu, A. L. & Ching, T. T., 4月 2024, 於: Aging Cell. 23, 4, e14103.

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1 引文斯高帕斯（Scopus）

Novel lissencephaly-associated NDEL1 variant reveals distinct roles of NDE1 and NDEL1 in nucleokinesis and human cortical malformations

Tsai, M. H., Ke, H. C., Lin, W. C., Nian, F. S., Huang, C. W., Cheng, H. Y., Hsu, C. S., Granata, T., Chang, C. H., Castellotti, B., Lin, S. Y., Doniselli, F. M., Lu, C. J., Franceschetti, S., Ragona, F., Hou, P. S., Canafoglia, L., Tung, C. Y., Lee, M. H. & Wang, W. J. 及其他1, Tsai, J. W., 6月 2024, 於: Acta Neuropathologica. 147, 1, 13.

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1 引文斯高帕斯（Scopus）

Primary cilia formation requires the Leigh syndrome–associated mitochondrial protein NDUFAF2

Lo, C. H., Liu, Z., Chen, S., Lin, F., Berneshawi, A. R., Yu, C. Q., Koo, E. B., Kowal, T. J., Ning, K., Hu, Y., Wang, W. J., Liao, Y. J. & Sun, Y., 1 7月 2024, 於: Journal of Clinical Investigation. 134, 13, e175560.

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1 引文斯高帕斯（Scopus）

Regulation of primary cilia disassembly through HUWE1-mediated TTBK2 degradation plays a crucial role in cerebellar development and medulloblastoma growth

Lin, I. H., Li, Y. R., Chang, C. H., Cheng, Y. W., Wang, Y. T., Tsai, Y. S., Lin, P. Y., Kao, C. H., Su, T. Y., Hsu, C. S., Tung, C. Y., Hsu, P. H., Ayrault, O., Chung, B. C., Tsai, J. W. & Wang, W. J., 10月 2024, 於: Cell Death and Differentiation. 31, 10, p. 1349-1361 13 p.

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1 引文斯高帕斯（Scopus）

Sarcopenia-related changes in serum GLP-1 level affect myogenic differentiation

Huang, H. H., Wang, Y. J., Jiang, H. Y., Yu, H. W., Chen, Y. Q., Chiou, A. & Kuo, J. C., 10月 2024, 於: Journal of Cachexia, Sarcopenia and Muscle. 15, 5, p. 1708-1721 14 p.

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TAF2, within the TFIID complex, regulates the expression of a subset of protein-coding genes

Cheng, I. H., Pi, W. C., Hsu, C. H., Guo, Y., Lai, J. L., Wang, G. G., Chung, B. C., Roeder, R. G. & Chen, W. Y., 12月 2024, 於: Cell Death Discovery. 10, 1, 244.

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2023

Activation of eIF4E-binding-protein-1 rescues mTORC1-induced sarcopenia by expanding lysosomal degradation capacity

Crombie, E. M., Kim, S., Adamson, S., Dong, H., Lu, T. C., Wu, Y., Wu, Y., Levy, Y., Stimple, N., Lam, W. M. R., Hey, H. W. D., Withers, D. J., Hsu, A. L., Bay, B. H., Ochala, J. & Tsai, S. Y., 2月 2023, 於: Journal of Cachexia, Sarcopenia and Muscle. 14, 1, p. 198-213 16 p.

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7 引文斯高帕斯（Scopus）

AKT2-mediated nuclear deformation leads to genome instability during epithelial-mesenchymal transition

Fan, J. R., Chang, S. N., Chu, C. T. & Chen, H. C., 16 6月 2023, 於: iScience. 26, 6, 106992.

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2 引文斯高帕斯（Scopus）

Development of vessel mimicking microfluidic device for studying mechano-response of endothelial cells

Chu, P. Y., Hsieh, H. Y., Chung, P. S., Wang, P. W., Wu, M. C., Chen, Y. Q., Kuo, J. C. & Fan, Y. J., 16 6月 2023, 於: iScience. 26, 6, 106927.

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8 引文斯高帕斯（Scopus）

Distinct sets of lysosomal genes define synucleinopathy and Tauopathy

Oh, K. W., Kim, D. K., Hsu, A. L. & Lee, S. J., 2023, 於: BMB Reports. 56, 12, p. 657-662 6 p.

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Early committed polarization of intracellular tension in response to cell shape determines the osteogenic differentiation of mesenchymal stromal cells

Wu, M. C., Yu, H. W., Chen, Y. Q., Ou, M. H., Serrano, R., Huang, G. L., Wang, Y. K., Lin, K. H., Fan, Y. J., Wu, C. C., del Álamo, J. C., Chiou, A., Chien, S. & Kuo, J. C., 6月 2023, 於: Acta Biomaterialia. 163, p. 287-301 15 p.

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8 引文斯高帕斯（Scopus）

Erratum: SET1 and p300 Act Synergistically, through Coupled Histone Modifications, in Transcriptional Activation by p53 (SET1 and p300 Act Synergistically, through Coupled Histone Modifications, in Transcriptional Activation by p53 (2013) 154(2) (297–310), (S0092867413007666), (10.1016/j.cell.2013.06.027))

Tang, Z., Chen, W. Y., Shimada, M., Nguyen, U. T. T., Kim, J., Sun, X. J., Sengoku, T., McGinty, R. K., Fernandez, J. P., Muir, T. W. & Roeder, R. G., 11 5月 2023, 於: Cell. 186, 10, p. 2280 1 p.

研究成果: Comment/debate

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1 引文斯高帕斯（Scopus）

Ethylene Glycol-Manipulated Syntheses of Calcium Carbonate Particles and DNA Capsules toward Efficient ATP-Responsive Cargo Release

Lin, Y. H., Singuru, M. M. R., Marpaung, D. S. S., Liao, W. C. & Chuang, M. C., 21 8月 2023, 於: ACS Applied Bio Materials. 6, 8, p. 3351-3360 10 p.

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5 引文斯高帕斯（Scopus）

Flap endonuclease Rad27 cleaves the RNA of R-loop structures to suppress telomere recombination

Liu, C. C., Chan, H. R., Su, G. C., Hsieh, Y. Z., Lei, K. H., Kato, T., Yu, T. Y., Kao, Y. W., Cheng, T. H., Chi, P. & Lin, J. J., 22 5月 2023, 於: Nucleic acids research. 51, 9, p. 4398-4414 17 p.

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5 引文斯高帕斯（Scopus）

Hybridization chain reaction-assisted enzyme cascade genosensor for the detection of Listeria monocytogenes

Yang, F. A., Wu, Y. T., Liu, Y. W. & Liao, W. C., 1 3月 2023, 於: Talanta. 254, 124193.

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7 引文斯高帕斯（Scopus）

IFF: Identifying key residues in intrinsically disordered regions of proteins using machine learning

Ho, W. L., Huang, H. C. & Huang, J. R., 9月 2023, 於: Protein Science. 32, 9, e4739.

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1 引文斯高帕斯（Scopus）

INPP5E regulates CD3ζ enrichment at the immune synapse by phosphoinositide distribution control

Chiu, T. Y., Lo, C. H., Lin, Y. H., Lai, Y. D., Lin, S. S., Fang, Y. T., Huang, W. S., Huang, S. Y., Tsai, P. Y., Yang, F. H., Chong, W. M., Wu, Y. C., Tsai, H. C., Liu, Y. W., Hsu, C. L., Liao, J. C. & Wang, W. J., 12月 2023, 於: Communications Biology. 6, 1, 911.

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2 引文斯高帕斯（Scopus）

Loss of cell-cell adhesion triggers cell migration through Rac1-dependent ROS generation

Chen, Y. H., Hsu, J. Y., Chu, C. T., Chang, Y. W., Fan, J. R., Yang, M.-H. & Chen, H. C., 1 2月 2023, 於: Life Science Alliance. 6, 2

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8 引文斯高帕斯（Scopus）

PAICS ubiquitination recruits UBAP2 to trigger phase separation for purinosome assembly

Chou, M. C., Wang, Y. H., Chen, F. Y., Kung, C. Y., Wu, K. P., Kuo, J. C., Chan, S. J., Cheng, M. L., Lin, C. Y., Chou, Y. C., Ho, M. C., Firestine, S., Huang, J. R. & Chen, R. H., 16 11月 2023, 於: Molecular Cell. 83, 22, p. 4123-4140.e12

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5 引文斯高帕斯（Scopus）

PTPN23 ubiquitination by WDR4 suppresses EGFR and c-MET degradation to define a lung cancer therapeutic target

Singh, S., Yeat, N. Y., Wang, Y. T., Lin, S. Y., Kuo, I. Y., Wu, K. P., Wang, W. J., Wang, W. C., Su, W. C., Wang, Y. C. & Chen, R. H., 10月 2023, 於: Cell Death and Disease. 14, 10, 671.

研究成果: Article › 同行評審

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3 引文斯高帕斯（Scopus）

Pyruvate kinase M2 modification by a lipid peroxidation byproduct acrolein contributes to kidney fibrosis

Kuo, C. W., Chen, D. H., Tsai, M. T., Lin, C.-C., Cheng, H. W., Tsay, Y. G. & Wang, H.-T., 2023, 於: Frontiers in Medicine. 10, 1151359.

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3 引文斯高帕斯（Scopus）

SAMS-1 coordinates HLH-30/TFEB and PHA-4/FOXA activities through histone methylation to mediate dietary restriction-induced autophagy and longevity

Lim, C. Y., Lin, H. T., Kumsta, C., Lu, T. C., Wang, F. Y., Kang, Y. H., Hansen, M., Ching, T. T. & Hsu, A. L., 2023, 於: Autophagy. 19, 1, p. 224-240 17 p.

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6 引文斯高帕斯（Scopus）

Sequential isolation of metabolites and lipids from a single sample to achieve multiomics by using TRIzol reagent

Kao, C. Y., Chang, C. T., Kuo, P. Y., Lin, C. J., Chiu, H. H. & Liao, H. W., 1 6月 2023, 於: Talanta. 258, 124416.

研究成果: Article › 同行評審

5 引文斯高帕斯（Scopus）

Smad4-mediated angiogenesis facilitates the beiging of white adipose tissue in mice

Wang, C., Wu, Y., Li, Y., Zhang, Y., Fung, Y. L., Tong, K. K., Lau, C. W., Xiang, L., Kwan, K. M., You, L. R., Huang, Y. & Tian, X. Y., 17 3月 2023, 於: iScience. 26, 3, 106272.

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4 引文斯高帕斯（Scopus）

Structural convergence endows nuclear transport receptor Kap114p with a transcriptional repressor function toward TATA-binding protein

Liao, C. C., Wang, Y. S., Pi, W. C., Wang, C. H., Wu, Y. M., Chen, W. Y. & Hsia, K. C., 12月 2023, 於: Nature Communications. 14, 1, 5518.

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2 引文斯高帕斯（Scopus）

Therapeutic inhibition of ATR in differentiated thyroid cancer

Lin, S. F., Lee, Y. Y., Wu, M. H., Lu, Y. L., Yeh, C. N., Chen, W. Y., Chou, T. C. & Wong, R. J., 2023, 於: Endocrine-Related Cancer. 30, 12, e230142.

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1 引文斯高帕斯（Scopus）

TRABID inhibition activates cGAS/STING-mediated anti-tumor immunity through mitosis and autophagy dysregulation

Chen, Y. H., Chen, H. H., Wang, W. J., Chen, H. Y., Huang, W. S., Kao, C. H., Lee, S. R., Yeat, N. Y., Yan, R. L., Chan, S. J., Wu, K. P. & Chen, R. H., 12月 2023, 於: Nature Communications. 14, 1, 3050.

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9 引文斯高帕斯（Scopus）

2022

A PRC2-Kdm5b axis sustains tumorigenicity of acute myeloid leukemia

Ren, Z., Kim, A., Huang, Y. T., Pi, W. C., Gong, W., Yu, X., Qi, J., Jin, J., Cai, L., Roeder, R. G., Chen, W. Y. & Wang, G. G., 1 3月 2022, 於: Proceedings of the National Academy of Sciences of the United States of America. 119, 9, e2122940119.

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15 引文斯高帕斯（Scopus）

Beth Levine’s Legacy: From the Discovery of BECN1 to Therapies. A Mentees’ Perspective

An, Z., Chiang, W. C., Fernández, Á. F., Franco, L. H., He, C. C., Huang, S. Y., Lee, E., Liu, Y., Sebti, S., Shoji-Kawata, S., Sirasanagandla, S., Wang, R. C., Wei, Y., Zhao, Y. & Vega-Rubin-de-Celis, S., 27 6月 2022, 於: Frontiers in Cell and Developmental Biology. 10, 891332.

研究成果: Review article › 同行評審

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2 引文斯高帕斯（Scopus）

Chemical interference with DSIF complex formation lowers synthesis of mutant huntingtin gene products and curtails mutant phenotypes

Deng, N., Wu, Y. Y., Feng, Y., Hsieh, W. C., Song, J. S., Lin, Y. S., Tseng, Y. H., Liao, W. J., Chu, Y. F., Liu, Y. C., Chang, E. C., Liu, C. R., Sheu, S. Y., Su, M. T., Kuo, H. C., Cohen, S. N. & Cheng, T. H., 9 8月 2022, 於: Proceedings of the National Academy of Sciences of the United States of America. 119, 32, e2204779119.

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6 引文斯高帕斯（Scopus）

Context-specific roles of diphthamide deficiency in hepatocellular carcinogenesis

Tu, W. L., Chih, Y. C., Shih, Y. T., Yu, Y. R., You, L. R. & Chen, C. M., 10月 2022, 於: Journal of Pathology. 258, 2, p. 149-163 15 p.

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3 引文斯高帕斯（Scopus）

Development of a traditional Chinese medicine-based agent for the treatment of cancer cachexia

Wu, K. C., Chu, P. C., Cheng, Y. J., Li, C. I., Tian, J., Wu, H. Y., Wu, S. H., Lai, Y. C., Kao, H. H., Hsu, A. L., Lin, H. W. & Lin, C. H., 8月 2022, 於: Journal of Cachexia, Sarcopenia and Muscle. 13, 4, p. 2073-2087 15 p.

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11 引文斯高帕斯（Scopus）

DNMT3b protects centromere integrity by restricting R-loop-mediated DNA damage

Shih, H. T., Chen, W. Y., Wang, H. Y., Chao, T., Huang, H. D., Chou, C. H. & Chang, Z. F., 6月 2022, 於: Cell Death and Disease. 13, 6, 546.

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10 引文斯高帕斯（Scopus）

DSIF modulates RNA polymerase II occupancy according to template G + C content

Deng, N., Zhang, Y., Ma, Z., Lin, R., Cheng, T. H., Tang, H., Snyder, M. P. & Cohen, S. N., 1 9月 2022, 於: NAR Genomics and Bioinformatics. 4, 3, lqac054.

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Effects of polyallylamine-coated nanoparticles on the optical and photochemical properties of rose bengal

Lin, K. Y., Tsay, Y. G. & Allen Chang, C., 1 9月 2022, 於: Journal of the Chinese Medical Association. 85, 9, p. 901-908 8 p.

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1 引文斯高帕斯（Scopus）

Engineered multivalent DNA capsules for multiplexed detection of genotoxicants via versatile controlled release mechanisms

Singuru, M. M. R., Liao, Y. C., Lin, G. M. H., Chen, W. T., Lin, Y. H., To, C. T., Liao, W. C., Hsu, C. H. & Chuang, M. C., 15 11月 2022, 於: Biosensors and Bioelectronics. 216, 114608.

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3 引文斯高帕斯（Scopus）

Erratum: Structural and Biochemical Characterization of Porcine Epidemic Diarrhea Virus Papain-Like Protease 2 (Journal of Virology (2022) 96:1 (e01372-21) DOI: 10.1128/JVI.01372-21)

Chu, H. F., Cheng, S. C., Sun, C. Y., Chou, C. Y., Lin, T.-H. & Chen, W. Y., 3月 2022, 於: Journal of Virology. 96, 6, e00091-22.

研究成果: Comment/debate

EZH2 noncanonically binds cMyc and p300 through a cryptic transactivation domain to mediate gene activation and promote oncogenesis

Wang, J., Yu, X., Gong, W., Liu, X., Park, K. S., Ma, A., Tsai, Y. H., Shen, Y., Onikubo, T., Pi, W. C., Allison, D. F., Liu, J., Chen, W. Y., Cai, L., Roeder, R. G., Jin, J. & Wang, G. G., 3月 2022, 於: Nature Cell Biology. 24, 3, p. 384-399 16 p.

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98 引文斯高帕斯（Scopus）

Mitophagy in aging and longevity

Guo, J. & Chiang, W. C., 4月 2022, 於: IUBMB Life. 74, 4, p. 296-316 21 p.

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29 引文斯高帕斯（Scopus）

Novel Bcl-2 Inhibitors Selectively Disrupt the Autophagy-Specific Bcl-2-Beclin 1 Protein-Protein Interaction

Dong, X., Liang, Q., Pan, Y. Z., Wang, X., Kuo, Y. C., Chiang, W. C., Zhang, X., Williams, N. S., Rizo, J., Levine, B. & De Brabander, J. K., 8 9月 2022, 於: ACS Medicinal Chemistry Letters. 13, 9, p. 1510-1516 7 p.

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7 引文斯高帕斯（Scopus）

Persistent TLR4 Activation Promotes Hepatocellular Carcinoma Growth through Positive Feedback Regulation by LIN28A/Let-7g miRNA

Chen, I. T., Cheng, A. C., Liu, Y. T., Yan, C., Cheng, Y. C., Chang, C. F. & Tseng, P. H., 8月 2022, 於: International Journal Of Molecular Sciences. 23, 15, 8419.

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12 引文斯高帕斯（Scopus）

Phase separation driven by interchangeable properties in the intrinsically disordered regions of protein paralogs

Chiu, S. H., Ho, W. L., Sun, Y. C., Kuo, J. C. & Huang, J. R., 12月 2022, 於: Communications Biology. 5, 1, 400.

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13 引文斯高帕斯（Scopus）

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