Yolk sac tumor of endometrium: A case report and literature review

Shih-Wen Lin, Shu-Wei Hsieh, Shih-Hung Huang, Hung-Shuo Liang, Chia-Yen Huang

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations


Objective: To report a rare case of endometrial yolk sac tumor (YST) and review published cases of YST of the endometrium.

Case report: A 68-year-old female presented with intermittent vaginal spotting for nine months. An endometrial biopsy showed adenocarcinoma. Complete surgical staging operation was performed and the final pathology revealed stage II endometrial yolk sac tumor. The post-operative a-fetoprotein (AFP) level was 133.4 ng/mL. Post-operative adjuvant chemotherapy with bleomycin, etoposide, and cisplatin (BEP) regimen was prescribed for 6 cycles. AFP levels were normal before the fourth cycle of chemotherapy. She is disease free 6 months after completion of therapy.

Conclusion: Primary YSTs arising in the endometrium is an extremely rare disease especially in postmenopausal women. Complete surgical staging operation with adjuvant chemotherapy will lead to good outcome in this disease. (C) 2019 Taiwan Association of Obstetrics & Gynecology. Publishing services by Elsevier B.V.

Original languageAmerican English
Pages (from-to)846-848
Number of pages3
JournalTaiwanese Journal of Obstetrics and Gynecology
Issue number6
StatePublished - Nov 2019


  • Yolk sac tumor
  • Endometrial cancer
  • Adjuvant chemotherapy


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