Yearly change in air pollution and brain aging among older adults: A community-based study in Taiwan

Ying Cen Lin, Kang Chen Fan, Chih Da Wu, Wen Chi Pan, Jiu Chiuan Chen, Yi Ping Chao, Yen Jun Lai, Yen Ling Chiu, Yi Fang Chuang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Air pollution is recognized as a modifiable risk factor for dementia, and recent evidence suggests that improving air quality could attenuate cognitive decline and reduce dementia risk. However, studies have yet to explore the effects of improved air quality on brain structures. This study aims to investigate the impact of air pollution reduction on cognitive functions and structural brain differences among cognitively normal older adults. Methods: Four hundred and thirty-one cognitively normal older adults were from the Epidemiology of Mild Cognitive Impairment study in Taiwan (EMCIT), a community-based cohort of adults aged 60 and older, between year 2017– 2021. Annual concentrations of PM2.5, NO2, O3, and PM10 at participants’ residential addresses during the 10 years before enrollment were estimated using ensemble mixed spatial models. The yearly rate of change (slope) in air pollutants was estimated for each participant. Cognitive functions and structural brain images were collected during enrollment. The relationships between the rate of air pollution change and cognitive functions were examined using linear regression models. For air pollutants with significant findings in relation to cognitive function, we further explored the association with brain structure. Results: Overall, all pollutant concentrations, except O3, decreased over the 10-year period. The yearly rates of change (slopes) in PM2.5 and NO2 were correlated with better attention (PM2.5: r = -0.1, p = 0.047; NO2: r = -0.1, p = 0.03) and higher white matter integrity in several brain regions. These regions included anterior thalamic radiation, superior longitudinal fasciculus, inferior longitudinal fasciculus, corticospinal tract, and inferior fronto-occipital fasciculus. Conclusions: Greater rate of reduction in air pollution was associated with better attention and attention-related white matter integrity. These results provide insight into the mechanism underlying the relationship between air pollution, brain health, and cognitive aging among older adults.

Original languageEnglish
Article number108876
JournalEnvironment International
Volume190
DOIs
StatePublished - Aug 2024

Keywords

  • Air pollution
  • Cognitive functions
  • Diffusion tensor imaging
  • Structural brain imaging

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