TY - JOUR
T1 - Women with endometriosis are more likely to suffer from migraines
T2 - A population-based study
AU - Yang, Meng Han
AU - Wang, Peng Hui
AU - Wang, Shuu Jiun
AU - Sun, Wei Zen
AU - Oyang, Yen Jen
AU - Fuh, Jong Ling
N1 - Funding Information:
Dr. Shuu-Jiun Wang has served on the advisory boards of Pfizer, Allergan, Daichi-Sankyo and Elli Lilly Taiwan. He has received speaking honoraria from local companies (Taiwan branches) of Pfizer, Elli Lilly, Boehringer Ingelheim and GSK. He has received research grants from the Taiwan National Science Council, Taipei-Veterans General Hospital, Pfizer and MSD Taiwan.
PY - 2012/3/19
Y1 - 2012/3/19
N2 - Previous research suggests that a co-morbid relationship exists between migraine and endometriosis; however, results have been inconsistent. In addition, female hormones, which are important in the pathogenesis and management of endometriosis, have been reported to precipitate migraine attacks and may confound the results. The aim of this population-based cohort study was to explore the relationship between migraine and endometriosis in women of reproductive age (18-51 years). Data were derived from the National Health Insurance Research Database of Taiwan, which contains outpatient and inpatient records from 2000 to 2007. Our study cohort included 20,220 endometriosis patients and 263,767 controls without endometriosis. We analyzed the prevalence of migraine in these women as recorded during the eight years of the database. Our results found that patients with endometriosis were more likely to suffer migraine headaches compared to controls (odds ratio [OR], 1.70; 95% confidence interval [CI] [1.59, 1.82]; p<0.001). In addition, the co-morbid association between migraine and endometriosis remained significant after the data were controlled for age and frequently utilized hormone therapies (OR, 1.37; 95% CI, [1.27, 1.47]; p<0.001). The results of this cohort study support the existence of a co-morbid relationship between migraine and endometriosis, even after adjusting for the possible effects of female hormone therapies on migraine attacks.
AB - Previous research suggests that a co-morbid relationship exists between migraine and endometriosis; however, results have been inconsistent. In addition, female hormones, which are important in the pathogenesis and management of endometriosis, have been reported to precipitate migraine attacks and may confound the results. The aim of this population-based cohort study was to explore the relationship between migraine and endometriosis in women of reproductive age (18-51 years). Data were derived from the National Health Insurance Research Database of Taiwan, which contains outpatient and inpatient records from 2000 to 2007. Our study cohort included 20,220 endometriosis patients and 263,767 controls without endometriosis. We analyzed the prevalence of migraine in these women as recorded during the eight years of the database. Our results found that patients with endometriosis were more likely to suffer migraine headaches compared to controls (odds ratio [OR], 1.70; 95% confidence interval [CI] [1.59, 1.82]; p<0.001). In addition, the co-morbid association between migraine and endometriosis remained significant after the data were controlled for age and frequently utilized hormone therapies (OR, 1.37; 95% CI, [1.27, 1.47]; p<0.001). The results of this cohort study support the existence of a co-morbid relationship between migraine and endometriosis, even after adjusting for the possible effects of female hormone therapies on migraine attacks.
UR - http://www.scopus.com/inward/record.url?scp=84863388837&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0033941
DO - 10.1371/journal.pone.0033941
M3 - Article
C2 - 22442736
AN - SCOPUS:84863388837
SN - 1932-6203
VL - 7
JO - PLoS ONE
JF - PLoS ONE
IS - 3
M1 - e33941
ER -