TY - JOUR
T1 - Wireless near-infrared spectroscopy system for determining brain hemoglobin levels in laboratory animals
AU - Kuo, Jinn Rung
AU - Chang, Ming Hsien
AU - Wang, Che Chuan
AU - Chio, Chung Ching
AU - Wang, Jhi Joung
AU - Lin, Bor-Shyh
PY - 2013/4/5
Y1 - 2013/4/5
N2 - Traumatic brain injury (TBI) is usually caused by brain shaking or impact. It can affect normal brain function and may even lead to disability or death. However, there are very few studies on the associated physiologic changes in humans or animals. In this study, a non-invasive, wireless multi-channel near-infrared spectroscopy (NIRS) was developed to continuously monitor the concentration change of oxyhemoglobin (HbO2), deoxyhemoglobin (HbR), and total hemoglobin (HbT) to elucidate changes in the physiological state of the brain during and after different strength impaction. The triphenyltetrazolium chloride (TTC) staining was also used to monitor changes of infarction volume after different strength impaction. The results indicated that the concentration changes of HbO2 and HbT, and the changes of infarction volumes were significantly related to the impact strength. In conclusion, the status of TBI can be clinically evaluated by detecting HbO2 and HbT changes. The system proposed here is stable, accurate, non-invasive, and mostly important wireless which can easily be used for TBI study.
AB - Traumatic brain injury (TBI) is usually caused by brain shaking or impact. It can affect normal brain function and may even lead to disability or death. However, there are very few studies on the associated physiologic changes in humans or animals. In this study, a non-invasive, wireless multi-channel near-infrared spectroscopy (NIRS) was developed to continuously monitor the concentration change of oxyhemoglobin (HbO2), deoxyhemoglobin (HbR), and total hemoglobin (HbT) to elucidate changes in the physiological state of the brain during and after different strength impaction. The triphenyltetrazolium chloride (TTC) staining was also used to monitor changes of infarction volume after different strength impaction. The results indicated that the concentration changes of HbO2 and HbT, and the changes of infarction volumes were significantly related to the impact strength. In conclusion, the status of TBI can be clinically evaluated by detecting HbO2 and HbT changes. The system proposed here is stable, accurate, non-invasive, and mostly important wireless which can easily be used for TBI study.
KW - Deoxyhemoglobin
KW - Near-infrared spectroscopy
KW - Oxyhemoglobin
KW - Total hemoglobin
KW - Traumatic brain injury
KW - Triphenyltetrazolium chloride
UR - http://www.scopus.com/inward/record.url?scp=84874404698&partnerID=8YFLogxK
U2 - 10.1016/j.jneumeth.2013.01.025
DO - 10.1016/j.jneumeth.2013.01.025
M3 - Article
C2 - 23391759
AN - SCOPUS:84874404698
SN - 0165-0270
VL - 214
SP - 204
EP - 209
JO - Journal of Neuroscience Methods
JF - Journal of Neuroscience Methods
IS - 2
ER -