What is the difference of cell deformation between push and pull?

Chia-Hung Tsai; S. Sakuma; F. Arai; M. Kaneko

What is the difference of cell deformation between push and pull?

Chia-Hung Tsai^*, S. Sakuma, F. Arai, M. Kaneko

^*Corresponding author for this work

Department of Mechanical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

2 Scopus citations

Abstract

The difference of cell deformation passing through a microchannel by positive- and negative-pressure driven flow, which are defined as "PUSH" and "PULL" in this paper, is investigated based on the experimental results. While both cases are commonly utilized in microfluidic applications, the aim of this work is to point out the fundamental difference of them regarding cell deformation. Experiments are carried out by using osmotic-swollen RBCs for exaggerating the difference. Two observational parameters, maximum insertion length and cell membrane curvature, are obtained for each tested RBC. According to the results, the cell deformation under PUSH and PULL is statistically different.

Original language	English
Title of host publication	18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
Publisher	Chemical and Biological Microsystems Society
Pages	793-795
Number of pages	3
ISBN (Electronic)	9780979806476
State	Published - Oct 2014
Event	18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 - San Antonio, United States Duration: 26 Oct 2014 → 30 Oct 2014

Publication series

Name	18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

Conference

Conference	18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
Country/Territory	United States
City	San Antonio
Period	26/10/14 → 30/10/14

Keywords

Cell deformability
Positive- and negative-pressure driven flow

Cite this

Tsai, C.-H., Sakuma, S., Arai, F., & Kaneko, M. (2014). What is the difference of cell deformation between push and pull? In 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 (pp. 793-795). (18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014). Chemical and Biological Microsystems Society.

Tsai, Chia-Hung ; Sakuma, S. ; Arai, F. et al. / What is the difference of cell deformation between push and pull?. 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. Chemical and Biological Microsystems Society, 2014. pp. 793-795 (18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014).

@inproceedings{8f5f6911c782447bb7f39e64e7b6df41,

title = "What is the difference of cell deformation between push and pull?",

abstract = "The difference of cell deformation passing through a microchannel by positive- and negative-pressure driven flow, which are defined as {"}PUSH{"} and {"}PULL{"} in this paper, is investigated based on the experimental results. While both cases are commonly utilized in microfluidic applications, the aim of this work is to point out the fundamental difference of them regarding cell deformation. Experiments are carried out by using osmotic-swollen RBCs for exaggerating the difference. Two observational parameters, maximum insertion length and cell membrane curvature, are obtained for each tested RBC. According to the results, the cell deformation under PUSH and PULL is statistically different.",

keywords = "Cell deformability, Positive- and negative-pressure driven flow",

author = "Chia-Hung Tsai and S. Sakuma and F. Arai and M. Kaneko",

year = "2014",

month = oct,

language = "English",

series = "18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014",

publisher = "Chemical and Biological Microsystems Society",

pages = "793--795",

booktitle = "18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014",

note = "18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 ; Conference date: 26-10-2014 Through 30-10-2014",

}

Tsai, C-H, Sakuma, S, Arai, F & Kaneko, M 2014, What is the difference of cell deformation between push and pull? in 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014, Chemical and Biological Microsystems Society, pp. 793-795, 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014, San Antonio, United States, 26/10/14.

What is the difference of cell deformation between push and pull? / Tsai, Chia-Hung; Sakuma, S.; Arai, F. et al.
18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. Chemical and Biological Microsystems Society, 2014. p. 793-795 (18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review