Wet-spinning-based Molding Process of Gelatin for Tissue Regeneration

Chia Yu Wang, Dewi Sartika, Ding Han Wang, Po Da Hong, Juin Hong Cherng, Shu Jen Chang, Cheng Che Liu, Yi Wen Wang*, Sheng Tang Wu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


This article presents an inexpensive method to fabricate gelatin, as a natural polymer, into monofilament fibers or other appropriate forms. Through the wet spinning method, gelatin fibers are produced by smooth extrusion in a suitable coagulation medium. To increase the functional surface of these gelatin fibers and their ability to mimic the features of tissues, gelatin can be molded into a tube form by referring to this concept. Examined by in vitro and in vivo tests, the gelatin tubes demonstrate a great potential for application in tissue engineering. Acting as a suitable filling gap material, gelatin tubes can be used to substitute the tissue in the damaged area (e.g., in the nervous or cardiovascular system), as well as to promote regeneration by providing a direct replacement of stem cells and neural circuitry. This protocol provides a detailed procedure for creating a biomaterial based on a natural polymer, and its implementation is expected to greatly benefit the development of correlative natural polymers, which help to realize tissue regeneration strategies.

Original languageEnglish
Article numbere58932
JournalJournal of Visualized Experiments
Issue number145
StatePublished - Mar 2019


  • Bioengineering
  • Biomaterial
  • Fiber
  • Gelatin
  • Issue 145
  • Molding
  • Regeneration
  • Tissue engineering
  • Tube
  • Wet spinning


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