Weak evidence of linkage with markers on chromosome 6p in Taiwanese schizophrenic families

H. G. Hwu*, M. W. Lin, P. C. Lee, J. I. Yeh, C. H. Liu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Several studies have reported suggestive evidence for linkage with markers on chromosome 6p in schizophrenic families. In order to replicate this finding, we have conducted a linkage study of schizophrenia with nine microsatellite markers on chromosome 6p21-24 in 39 Taiwanese schizophrenic nuclear families with at least two affected siblings. Each subject was interviewed by using the Psychiatrists Diagnostic Assessment Schedule and diagnoses were made based on DSM-IV criteria. Two diagnostic (narrow and broad) models were used to define the disease phenotype. Linkage analysis was performed by using the LINKAGE (FASTLINK v3.0) and GENEHUNTER (version 1.1) programs. With the broad diagnostic model, the marker D6S296 produced a maximum two-point lod score of 1.46 at θ = 0.2 under the recessive transmission model and a lod score of 0.72 for D6S285 at 0 = 0.1 under the dominant transmission model. With the narrow diagnostic model, a maximum lod score of 1.35 (9 = 0.2) was found for the marker D6S296 under the recessive model and 0.85 (9 = 0.1) for D6S285 under the dominant model. Assuming locus heterogeneity, a multipoint lod score of 0.85 was obtained around markers D6S296 and D6S277 under the narrow and recessive model. A maximum NPL score of 1.36 (P = 0.08) was observed around D6S296 with the broad diagnostic model. Under the narrow model, two small peaks of NPL score were also found near the markers D6S296 and D6S274. Our results suggest a weak evidence of linkage of schizophrenia with markers on chromosome 6p22 and 6p24 regions in a proportion of Taiwanese families. These results are compatible with genetic heterogeneity of schizophrenia with different modes of transmission.

Original languageEnglish
Pages (from-to)530
Number of pages1
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume81
Issue number6
StatePublished - 6 Nov 1998

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