WAKE-mediated modulation of cVA perception via a hierarchical neuro-endocrine axis in Drosophila male-male courtship behaviour

Shiu Ling Chen; Bo Ting Liu; Wang Pao Lee; Sin Bo Liao; Yao Bang Deng; Chia Lin Wu; Shuk Man Ho; Bing Xian Shen; Guan Hock Khoo; Wei Chiang Shiu; Chih Hsuan Chang; Hui Wen Shih; Jung Kun Wen; Tsuo Hung Lan; Chih Chien Lin; Yu Chen Tsai; Huey Fen Tzeng; Tsai Feng Fu

doi:10.1038/s41467-022-30165-2

WAKE-mediated modulation of cVA perception via a hierarchical neuro-endocrine axis in Drosophila male-male courtship behaviour

Shiu Ling Chen, Bo Ting Liu, Wang Pao Lee, Sin Bo Liao, Yao Bang Deng, Chia Lin Wu, Shuk Man Ho, Bing Xian Shen, Guan Hock Khoo, Wei Chiang Shiu, Chih Hsuan Chang, Hui Wen Shih, Jung Kun Wen, Tsuo Hung Lan, Chih Chien Lin, Yu Chen Tsai, Huey Fen Tzeng^*, Tsai Feng Fu

^*Corresponding author for this work

Department of Psychiatry

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The nervous and endocrine systems coordinate with each other to closely influence physiological and behavioural responses in animals. Here we show that WAKE (encoded by wide awake, also known as wake) modulates membrane levels of GABA_A receptor Resistance to Dieldrin (Rdl), in insulin-producing cells of adult male Drosophila melanogaster. This results in changes to secretion of insulin-like peptides which is associated with changes in juvenile hormone biosynthesis in the corpus allatum, which in turn leads to a decrease in 20-hydroxyecdysone levels. A reduction in ecdysone signalling changes neural architecture and lowers the perception of the male-specific sex pheromone 11-cis-vaccenyl acetate by odorant receptor 67d olfactory neurons. These finding explain why WAKE-deficient in Drosophila elicits significant male-male courtship behaviour.

Original language	English
Article number	2518
Journal	Nature Communications
Volume	13
Issue number	1
DOIs	https://doi.org/10.1038/s41467-022-30165-2
State	Published - Dec 2022

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Chen, S. L., Liu, B. T., Lee, W. P., Liao, S. B., Deng, Y. B., Wu, C. L., Ho, S. M., Shen, B. X., Khoo, G. H., Shiu, W. C., Chang, C. H., Shih, H. W., Wen, J. K., Lan, T. H., Lin, C. C., Tsai, Y. C., Tzeng, H. F., & Fu, T. F. (2022). WAKE-mediated modulation of cVA perception via a hierarchical neuro-endocrine axis in Drosophila male-male courtship behaviour. Nature Communications, 13(1), Article 2518. https://doi.org/10.1038/s41467-022-30165-2

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title = "WAKE-mediated modulation of cVA perception via a hierarchical neuro-endocrine axis in Drosophila male-male courtship behaviour",

abstract = "The nervous and endocrine systems coordinate with each other to closely influence physiological and behavioural responses in animals. Here we show that WAKE (encoded by wide awake, also known as wake) modulates membrane levels of GABAA receptor Resistance to Dieldrin (Rdl), in insulin-producing cells of adult male Drosophila melanogaster. This results in changes to secretion of insulin-like peptides which is associated with changes in juvenile hormone biosynthesis in the corpus allatum, which in turn leads to a decrease in 20-hydroxyecdysone levels. A reduction in ecdysone signalling changes neural architecture and lowers the perception of the male-specific sex pheromone 11-cis-vaccenyl acetate by odorant receptor 67d olfactory neurons. These finding explain why WAKE-deficient in Drosophila elicits significant male-male courtship behaviour.",

author = "Chen, {Shiu Ling} and Liu, {Bo Ting} and Lee, {Wang Pao} and Liao, {Sin Bo} and Deng, {Yao Bang} and Wu, {Chia Lin} and Ho, {Shuk Man} and Shen, {Bing Xian} and Khoo, {Guan Hock} and Shiu, {Wei Chiang} and Chang, {Chih Hsuan} and Shih, {Hui Wen} and Wen, {Jung Kun} and Lan, {Tsuo Hung} and Lin, {Chih Chien} and Tsai, {Yu Chen} and Tzeng, {Huey Fen} and Fu, {Tsai Feng}",

note = "Publisher Copyright: {\textcopyright} 2022, The Author(s).",

year = "2022",

month = dec,

doi = "10.1038/s41467-022-30165-2",

language = "English",

volume = "13",

journal = "Nature Communications",

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Chen, SL, Liu, BT, Lee, WP, Liao, SB, Deng, YB, Wu, CL, Ho, SM, Shen, BX, Khoo, GH, Shiu, WC, Chang, CH, Shih, HW, Wen, JK, Lan, TH, Lin, CC, Tsai, YC, Tzeng, HF & Fu, TF 2022, 'WAKE-mediated modulation of cVA perception via a hierarchical neuro-endocrine axis in Drosophila male-male courtship behaviour', Nature Communications, vol. 13, no. 1, 2518. https://doi.org/10.1038/s41467-022-30165-2

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AU - Chen, Shiu Ling

AU - Liu, Bo Ting

AU - Lee, Wang Pao

AU - Liao, Sin Bo

AU - Deng, Yao Bang

AU - Wu, Chia Lin

AU - Ho, Shuk Man

AU - Shen, Bing Xian

AU - Khoo, Guan Hock

AU - Shiu, Wei Chiang

AU - Chang, Chih Hsuan

AU - Shih, Hui Wen

AU - Wen, Jung Kun

AU - Lan, Tsuo Hung

AU - Lin, Chih Chien

AU - Tsai, Yu Chen

AU - Tzeng, Huey Fen

AU - Fu, Tsai Feng

PY - 2022/12

Y1 - 2022/12

N2 - The nervous and endocrine systems coordinate with each other to closely influence physiological and behavioural responses in animals. Here we show that WAKE (encoded by wide awake, also known as wake) modulates membrane levels of GABAA receptor Resistance to Dieldrin (Rdl), in insulin-producing cells of adult male Drosophila melanogaster. This results in changes to secretion of insulin-like peptides which is associated with changes in juvenile hormone biosynthesis in the corpus allatum, which in turn leads to a decrease in 20-hydroxyecdysone levels. A reduction in ecdysone signalling changes neural architecture and lowers the perception of the male-specific sex pheromone 11-cis-vaccenyl acetate by odorant receptor 67d olfactory neurons. These finding explain why WAKE-deficient in Drosophila elicits significant male-male courtship behaviour.

AB - The nervous and endocrine systems coordinate with each other to closely influence physiological and behavioural responses in animals. Here we show that WAKE (encoded by wide awake, also known as wake) modulates membrane levels of GABAA receptor Resistance to Dieldrin (Rdl), in insulin-producing cells of adult male Drosophila melanogaster. This results in changes to secretion of insulin-like peptides which is associated with changes in juvenile hormone biosynthesis in the corpus allatum, which in turn leads to a decrease in 20-hydroxyecdysone levels. A reduction in ecdysone signalling changes neural architecture and lowers the perception of the male-specific sex pheromone 11-cis-vaccenyl acetate by odorant receptor 67d olfactory neurons. These finding explain why WAKE-deficient in Drosophila elicits significant male-male courtship behaviour.

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JO - Nature Communications

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ER -

WAKE-mediated modulation of cVA perception via a hierarchical neuro-endocrine axis in Drosophila male-male courtship behaviour

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