Vitamin E containing polymer micelles for reducing normal cell cytotoxicity and enhancing chemotherapy efficacy

Kuan Yi Lee, Yi Ting Chiang, Ning Yu Hsu, Chieh Yu Yang, Chun Liang Lo*, Chen An Ku

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

An α-tocopheryl succinate (α-TOS) containing diblock copolymer micellar system was used to deliver doxorubicin (Dox), an anticancer drug, for HCT116 colon cancer therapy. The α-TOS containing diblock copolymers were synthesized by conjugation of α-TOS molecules and a mPEG-b-PHEMA hydrophilic diblock copolymer by ester bonds. The Dox-loaded polymeric micelles were then obtained by solvent exchange process. In acidic surroundings such as endosomes or secondary lysosomes, the structures of the Dox-loaded polymeric micelles deformed and released the drug loads. Additionally, Dox-loaded polymeric micelles enhanced the cytotoxicity of Dox and α-TOS to cancer cells in vitro. Dox-loaded polymeric micelles also showed an exceptional tumor inhibiting effect in vivo. This study indicates that the α-TOS containing polymeric micelle system can be used as a drug carrier for cancer therapy.

Original languageEnglish
Article number3742
Pages (from-to)286-296
Number of pages11
JournalActa Biomaterialia
Volume24
DOIs
StatePublished - 15 Sep 2015

Keywords

  • Cancer therapy
  • Doxorubicin
  • Intracellular drug delivery
  • Micelles
  • α-Tocopheryl succinate

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