TY - JOUR
T1 - Visual cortex excitability and plasticity associated with remission from chronic to episodic migraine
AU - Chen, Wei Ta
AU - Wang, Shuu Jiun
AU - Fuh, Jong Ling
AU - Ko, Yu Chieh
AU - Lee, Yi Chung
AU - Hämäläinen, Matti S.
AU - Lin, Yung Yang
N1 - Funding Information:
This study was supported by the National Science Council of Taiwan [NSC 94-2314-B-038-014 and NSC-96-2314-B-075-073-MY3 to WT, NSC-98-2321-B-010-007, NSC-99-2321-B-010-004 and NSC-100-2321-B-010-004 to YY, NSC-95-2314-B-010-031-MY3NSC and NSC 99-2911-I-008-100 (NSC support for the Center for Dynamical Biomarkers and Translational Medicine, National Central University, Taiwan) to SJ]; Taipei Veterans General Hospital (V98B2-004 to WT, V99C1-063 to SJ, V97ER3-006, VGHUST97-P6-24, V97C1-034, VGH ER3-98-002, VGH-S4-98-018, VGH-C1-99-156 and VGH-ER3-99-006 to YY); Brain Research Center, National Yang-Ming University; and the Ministry of Education, Taipei, Taiwan (Aim for the Top University Plan to SJ).
PY - 2012/5
Y1 - 2012/5
N2 - Objective: Previous magnetoencephalographic (MEG) studies showed different P100m (where 'm' denotes the magnetic counterpart of P100 in conventional visual evoked potentials) responses between episodic migraine (EM) and chronic migraine (CM) interictally. This study investigated the changes of visual P100m in CM patients who remitted to EM from CM after treatment.Methods: At baseline, 25 patients with CM were studied interictally. For each patient, 30 sequential blocks of 50 P100m responses were obtained by MEG. Sub-averaged amplitudes at blocks 2, 9, 16, 23 and 30 were further compared with that at block 1 to assess response habituation or potentiation (i.e. significant decrease or increase at either block vs block 1). The same study was repeated in those patients who remitted from CM to EM after topiramate treatment.Results: In total, 10 CM patients remitted to EM after treatment. In the follow-up study of these patients during the interictal stage, the P100m at block 1 decreased in amplitude from 53.6 ± 6.6 nAm before remission to 43.0 ± 5.1 nAm (p = 0.028), and the responses at subsequent blocks switched from habituation (amplitude block 30 < block 1 before remission, p = 0.011) to potentiation (block 2 > block 1, p = 0.028).Conclusion: The pattern of P100m responses to consecutive stimulation changes with the transition from CM to EM. Visual cortex plasticity might be a potential biomarker reflecting clinical remission of CM.
AB - Objective: Previous magnetoencephalographic (MEG) studies showed different P100m (where 'm' denotes the magnetic counterpart of P100 in conventional visual evoked potentials) responses between episodic migraine (EM) and chronic migraine (CM) interictally. This study investigated the changes of visual P100m in CM patients who remitted to EM from CM after treatment.Methods: At baseline, 25 patients with CM were studied interictally. For each patient, 30 sequential blocks of 50 P100m responses were obtained by MEG. Sub-averaged amplitudes at blocks 2, 9, 16, 23 and 30 were further compared with that at block 1 to assess response habituation or potentiation (i.e. significant decrease or increase at either block vs block 1). The same study was repeated in those patients who remitted from CM to EM after topiramate treatment.Results: In total, 10 CM patients remitted to EM after treatment. In the follow-up study of these patients during the interictal stage, the P100m at block 1 decreased in amplitude from 53.6 ± 6.6 nAm before remission to 43.0 ± 5.1 nAm (p = 0.028), and the responses at subsequent blocks switched from habituation (amplitude block 30 < block 1 before remission, p = 0.011) to potentiation (block 2 > block 1, p = 0.028).Conclusion: The pattern of P100m responses to consecutive stimulation changes with the transition from CM to EM. Visual cortex plasticity might be a potential biomarker reflecting clinical remission of CM.
KW - Migraine
KW - chronic migraine
KW - magnetoencephalography
KW - topiramate
KW - visual cortical excitability
KW - visual evoked magnetic field
UR - http://www.scopus.com/inward/record.url?scp=84861810247&partnerID=8YFLogxK
U2 - 10.1177/0333102412443337
DO - 10.1177/0333102412443337
M3 - Article
C2 - 22529191
AN - SCOPUS:84861810247
SN - 0333-1024
VL - 32
SP - 537
EP - 543
JO - Cephalalgia
JF - Cephalalgia
IS - 7
ER -